Age-related changes in the striatal dopaminergic system in the living brain: A multiparametric PET study in conscious monkeys

In the present study, age‐related changes in the striatal dopaminergic system were examined in the living brains of conscious young (6.2 ± 1.5 years old) and aged (20.2 ± 2.6 years old) monkeys (Macaca mulatta) using positron emission tomography (PET). L‐[β‐11C]DOPA and [11C]β‐CFT were applied to de...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2002-07, Vol.45 (1), p.38-45
Hauptverfasser:	Harada, Norihiro, Nishiyama, Shingo, Satoh, Kengo, Fukumoto, Dai, Kakiuchi, Takeharu, Tsukada, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Benzazepines - administration & dosage Benzazepines - pharmacokinetics Cocaine - analogs & derivatives Cocaine - pharmacokinetics Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism D1 receptor D2 receptor Dopamine - metabolism dopamine synthesis Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacokinetics Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Extracellular Space - metabolism Levodopa - pharmacokinetics Macaca mulatta Magnetic Resonance Imaging Male Microdialysis monkey brain Piperazines - administration & dosage Piperazines - pharmacology positron emission tomography Raclopride - pharmacokinetics Tomography, Emission-Computed transporter
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