Tocopherols enhance neurogenesis in dentate gyrus of adult rats
In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal life. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The e...
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| Veröffentlicht in: | International journal for vitamin and nutrition research 2002-05, Vol.72 (3), p.170-176 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | CUPPINI, Riccardo CIARONI, Sandra CECCHINI, Tiziana AMBROGINI, Patrizia FERRI, Paola CUPPINI, Carla NINFALI, Paolino DEL GRANDE, Paolo |
| description | In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal life. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta-tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death. |
| doi_str_mv | 10.1024/0300-9831.72.3.170 |
| format | Article |
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The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta-tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death.</description><identifier>ISSN: 0300-9831</identifier><identifier>EISSN: 1664-2821</identifier><identifier>DOI: 10.1024/0300-9831.72.3.170</identifier><identifier>PMID: 12098885</identifier><identifier>CODEN: IJVNAP</identifier><language>eng</language><publisher>Bern: Hogrefe & Huber</publisher><subject>alpha-Tocopherol - administration & dosage ; Animals ; beta-Tocopherol - administration & dosage ; Biological and medical sciences ; Brain Chemistry ; Cell Count ; Cell Division - drug effects ; Dentate Gyrus - cytology ; Dentate Gyrus - drug effects ; Development. Senescence. Regeneration. Transplantation ; Fluorescent Antibody Technique, Indirect ; Fundamental and applied biological sciences. Psychology ; Male ; Microscopy, Fluorescence ; Neurons - cytology ; Rats ; Rats, Sprague-Dawley ; Vertebrates: nervous system and sense organs ; Vitamin E - analysis ; Vitamin E - blood</subject><ispartof>International journal for vitamin and nutrition research, 2002-05, Vol.72 (3), p.170-176</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-bd7496c47f64847017ee146266095d291a0dc4595d9fe8f12a383bb7db120b0d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13713784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12098885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUPPINI, Riccardo</creatorcontrib><creatorcontrib>CIARONI, Sandra</creatorcontrib><creatorcontrib>CECCHINI, Tiziana</creatorcontrib><creatorcontrib>AMBROGINI, Patrizia</creatorcontrib><creatorcontrib>FERRI, Paola</creatorcontrib><creatorcontrib>CUPPINI, Carla</creatorcontrib><creatorcontrib>NINFALI, Paolino</creatorcontrib><creatorcontrib>DEL GRANDE, Paolo</creatorcontrib><title>Tocopherols enhance neurogenesis in dentate gyrus of adult rats</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description>In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal life. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta-tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death.</description><subject>alpha-Tocopherol - administration & dosage</subject><subject>Animals</subject><subject>beta-Tocopherol - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry</subject><subject>Cell Count</subject><subject>Cell Division - drug effects</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - drug effects</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Microscopy, Fluorescence</subject><subject>Neurons - cytology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vitamin E - analysis</subject><subject>Vitamin E - blood</subject><issn>0300-9831</issn><issn>1664-2821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EoqXwBxiQF9gS_NXYmRCq-JIqsZTZcuxLG5TGxU6G_vu6akSnu-F5X909CN1TklPCxDPhhGSl4jSXLOc5leQCTWlRiIwpRi_R9B-YoJsYfwnhkipxjSaUkVIpNZ-il5W3freB4NuIoduYzgLuYAh-DR3EJuKmww663vSA1_swROxrbNzQ9jiYPt6iq9q0Ee7GOUM_72-rxWe2_P74WrwuM8tZ2WeVk6IsrJB1IZSQhEoAKgpWFKScO1ZSQ5wV87SXNaiaMsMVryrpqnRqRRyfoadT7y74vwFir7dNtNC2pgM_RJ0eU4wplUB2Am3wMQao9S40WxP2mhJ91KaPVvTRipZMc520pdDD2D5UW3DnyOgpAY8jYKI1bR2SpyaeuSSWSyX4AYMFdCM</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>CUPPINI, Riccardo</creator><creator>CIARONI, Sandra</creator><creator>CECCHINI, Tiziana</creator><creator>AMBROGINI, Patrizia</creator><creator>FERRI, Paola</creator><creator>CUPPINI, Carla</creator><creator>NINFALI, Paolino</creator><creator>DEL GRANDE, Paolo</creator><general>Hogrefe & Huber</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Tocopherols enhance neurogenesis in dentate gyrus of adult rats</title><author>CUPPINI, Riccardo ; CIARONI, Sandra ; CECCHINI, Tiziana ; AMBROGINI, Patrizia ; FERRI, Paola ; CUPPINI, Carla ; NINFALI, Paolino ; DEL GRANDE, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-bd7496c47f64847017ee146266095d291a0dc4595d9fe8f12a383bb7db120b0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>alpha-Tocopherol - administration & dosage</topic><topic>Animals</topic><topic>beta-Tocopherol - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry</topic><topic>Cell Count</topic><topic>Cell Division - drug effects</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - drug effects</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Microscopy, Fluorescence</topic><topic>Neurons - cytology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vitamin E - analysis</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUPPINI, Riccardo</creatorcontrib><creatorcontrib>CIARONI, Sandra</creatorcontrib><creatorcontrib>CECCHINI, Tiziana</creatorcontrib><creatorcontrib>AMBROGINI, Patrizia</creatorcontrib><creatorcontrib>FERRI, Paola</creatorcontrib><creatorcontrib>CUPPINI, Carla</creatorcontrib><creatorcontrib>NINFALI, Paolino</creatorcontrib><creatorcontrib>DEL GRANDE, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUPPINI, Riccardo</au><au>CIARONI, Sandra</au><au>CECCHINI, Tiziana</au><au>AMBROGINI, Patrizia</au><au>FERRI, Paola</au><au>CUPPINI, Carla</au><au>NINFALI, Paolino</au><au>DEL GRANDE, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tocopherols enhance neurogenesis in dentate gyrus of adult rats</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>72</volume><issue>3</issue><spage>170</spage><epage>176</epage><pages>170-176</pages><issn>0300-9831</issn><eissn>1664-2821</eissn><coden>IJVNAP</coden><abstract>In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal life. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta-tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death.</abstract><cop>Bern</cop><cop>Kirkland, WA</cop><cop>Toronto, ON</cop><pub>Hogrefe & Huber</pub><pmid>12098885</pmid><doi>10.1024/0300-9831.72.3.170</doi><tpages>7</tpages></addata></record> |
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| subjects | alpha-Tocopherol - administration & dosage Animals beta-Tocopherol - administration & dosage Biological and medical sciences Brain Chemistry Cell Count Cell Division - drug effects Dentate Gyrus - cytology Dentate Gyrus - drug effects Development. Senescence. Regeneration. Transplantation Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Male Microscopy, Fluorescence Neurons - cytology Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs Vitamin E - analysis Vitamin E - blood |
| title | Tocopherols enhance neurogenesis in dentate gyrus of adult rats |
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