Renal allograft function in matched pediatric and adult recipient pairs of the same donor
To study the effect of donor age on kidney function, the authors investigated matched pairs from the same kidney donor given to a pediatric or an adult recipient. Fifteen matched pairs of an adult and a pediatric patient, selected from the Eurotransplant registry, receiving the renal graft from the...
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| Veröffentlicht in: | Transplantation 2004-04, Vol.77 (8), p.1191-1194 |
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| creator | PAPE, Laps OFFNER, Gisela EHRICH, Jochen H. H DE BOER, Jan PERSIJN, Guido G |
| description | To study the effect of donor age on kidney function, the authors investigated matched pairs from the same kidney donor given to a pediatric or an adult recipient.
Fifteen matched pairs of an adult and a pediatric patient, selected from the Eurotransplant registry, receiving the renal graft from the same cadaveric donor were selected for analysis of graft function over 7 years. Nine matched pairs were from adult donors (mean age, 40 years; range, 23-60 years) and six from pediatric donors (mean age, 11 years; range, 4-15 years). All recipients had comparable immunosuppression with cyclosporine A, prednisolone, and azathioprine and comparable numbers of acute rejection, cytomegalovirus reactivation, and antihypertensive therapy. Mean age of pediatric and adult recipients at transplantation was 5 years (range, 1-9 years) and 38 years (range, 25-60 years), respectively.
The calculated glomerular filtration rate (GFR) corrected to body surface area was not different in adult and pediatric recipients. Initial absolute GFR was significantly lower in pediatric recipients (27 mL/ min; range, 17-38 mL/min) than in adult recipients (54 mL/min; range, 25-74 mL/min) (P |
| doi_str_mv | 10.1097/01.TP.0000120099.92220.7A |
| format | Article |
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Fifteen matched pairs of an adult and a pediatric patient, selected from the Eurotransplant registry, receiving the renal graft from the same cadaveric donor were selected for analysis of graft function over 7 years. Nine matched pairs were from adult donors (mean age, 40 years; range, 23-60 years) and six from pediatric donors (mean age, 11 years; range, 4-15 years). All recipients had comparable immunosuppression with cyclosporine A, prednisolone, and azathioprine and comparable numbers of acute rejection, cytomegalovirus reactivation, and antihypertensive therapy. Mean age of pediatric and adult recipients at transplantation was 5 years (range, 1-9 years) and 38 years (range, 25-60 years), respectively.
The calculated glomerular filtration rate (GFR) corrected to body surface area was not different in adult and pediatric recipients. Initial absolute GFR was significantly lower in pediatric recipients (27 mL/ min; range, 17-38 mL/min) than in adult recipients (54 mL/min; range, 25-74 mL/min) (P <0.05) and remained lower in the following years. Initially, pediatric donor kidneys transplanted into pediatric recipients showed a lower absolute GFR than those transplanted into adults, however, approaching the GFR in adult recipients later. Adult donor kidneys transplanted into pediatric recipients showed a persistently lower absolute GFR in children compared with those transplanted into adult recipients.
The authors conclude that adult donor kidneys in pediatric recipients decrease GFR in the early stages and lack an increase in GFR with growth of the child.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.TP.0000120099.92220.7A</identifier><identifier>PMID: 15114083</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Child ; Child, Preschool ; Combined surgery. Multiple transplantations ; Cytomegalovirus ; Europe ; Female ; Glomerular Filtration Rate ; Humans ; Infant ; Kidney Transplantation - physiology ; Male ; Medical sciences ; Middle Aged ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue and Organ Procurement ; Tissue Donors</subject><ispartof>Transplantation, 2004-04, Vol.77 (8), p.1191-1194</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-66ba53c6f2a267d2be970a88185a77acc24dfe804d32c46db54395e870b26b5b3</citedby><cites>FETCH-LOGICAL-c425t-66ba53c6f2a267d2be970a88185a77acc24dfe804d32c46db54395e870b26b5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15745793$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15114083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PAPE, Laps</creatorcontrib><creatorcontrib>OFFNER, Gisela</creatorcontrib><creatorcontrib>EHRICH, Jochen H. H</creatorcontrib><creatorcontrib>DE BOER, Jan</creatorcontrib><creatorcontrib>PERSIJN, Guido G</creatorcontrib><title>Renal allograft function in matched pediatric and adult recipient pairs of the same donor</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>To study the effect of donor age on kidney function, the authors investigated matched pairs from the same kidney donor given to a pediatric or an adult recipient.
Fifteen matched pairs of an adult and a pediatric patient, selected from the Eurotransplant registry, receiving the renal graft from the same cadaveric donor were selected for analysis of graft function over 7 years. Nine matched pairs were from adult donors (mean age, 40 years; range, 23-60 years) and six from pediatric donors (mean age, 11 years; range, 4-15 years). All recipients had comparable immunosuppression with cyclosporine A, prednisolone, and azathioprine and comparable numbers of acute rejection, cytomegalovirus reactivation, and antihypertensive therapy. Mean age of pediatric and adult recipients at transplantation was 5 years (range, 1-9 years) and 38 years (range, 25-60 years), respectively.
The calculated glomerular filtration rate (GFR) corrected to body surface area was not different in adult and pediatric recipients. Initial absolute GFR was significantly lower in pediatric recipients (27 mL/ min; range, 17-38 mL/min) than in adult recipients (54 mL/min; range, 25-74 mL/min) (P <0.05) and remained lower in the following years. Initially, pediatric donor kidneys transplanted into pediatric recipients showed a lower absolute GFR than those transplanted into adults, however, approaching the GFR in adult recipients later. Adult donor kidneys transplanted into pediatric recipients showed a persistently lower absolute GFR in children compared with those transplanted into adult recipients.
The authors conclude that adult donor kidneys in pediatric recipients decrease GFR in the early stages and lack an increase in GFR with growth of the child.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined surgery. Multiple transplantations</subject><subject>Cytomegalovirus</subject><subject>Europe</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Infant</subject><subject>Kidney Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue and Organ Procurement</subject><subject>Tissue Donors</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCKyCzgF3C-D9eXlX8VKpEhS4LVtbEdqhR4gQ7WfD2BHqlsutsZvOdM9J8hLxh0DKw5j2w9nTbwj6MA1jbWs45tOb4hByYErLR0MFTcgCQrGFCmAvyotafO6-EMc_JBVOMSejEgXz_GjOOFMdx_lFwWOmwZb-mOdOU6YSrv4uBLjEkXEvyFHOgGLZxpSX6tKSYV7pgKpXOA13vIq04RRrmPJeX5NmAY42vzvuSfPv44XT1ubn58un66njTeMnV2mjdoxJeDxy5NoH30RrArmOdQmPQey7DEDuQQXAvdeiVFFbFzkDPda96cUne3fcuZf61xbq6KVUfxxFznLfqDNvLNDOPgsxYw0GLHbT3oC9zrSUObilpwvLbMXB_BThg7nTrHgS4fwKcOe7Z1-cjWz_F8JA8f3wH3p4BrB7HoWD2qf7HGamMFeIPZs2OZQ</recordid><startdate>20040427</startdate><enddate>20040427</enddate><creator>PAPE, Laps</creator><creator>OFFNER, Gisela</creator><creator>EHRICH, Jochen H. H</creator><creator>DE BOER, Jan</creator><creator>PERSIJN, Guido G</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040427</creationdate><title>Renal allograft function in matched pediatric and adult recipient pairs of the same donor</title><author>PAPE, Laps ; OFFNER, Gisela ; EHRICH, Jochen H. H ; DE BOER, Jan ; PERSIJN, Guido G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-66ba53c6f2a267d2be970a88185a77acc24dfe804d32c46db54395e870b26b5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined surgery. Multiple transplantations</topic><topic>Cytomegalovirus</topic><topic>Europe</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Infant</topic><topic>Kidney Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue and Organ Procurement</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAPE, Laps</creatorcontrib><creatorcontrib>OFFNER, Gisela</creatorcontrib><creatorcontrib>EHRICH, Jochen H. H</creatorcontrib><creatorcontrib>DE BOER, Jan</creatorcontrib><creatorcontrib>PERSIJN, Guido G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PAPE, Laps</au><au>OFFNER, Gisela</au><au>EHRICH, Jochen H. H</au><au>DE BOER, Jan</au><au>PERSIJN, Guido G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal allograft function in matched pediatric and adult recipient pairs of the same donor</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2004-04-27</date><risdate>2004</risdate><volume>77</volume><issue>8</issue><spage>1191</spage><epage>1194</epage><pages>1191-1194</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>To study the effect of donor age on kidney function, the authors investigated matched pairs from the same kidney donor given to a pediatric or an adult recipient.
Fifteen matched pairs of an adult and a pediatric patient, selected from the Eurotransplant registry, receiving the renal graft from the same cadaveric donor were selected for analysis of graft function over 7 years. Nine matched pairs were from adult donors (mean age, 40 years; range, 23-60 years) and six from pediatric donors (mean age, 11 years; range, 4-15 years). All recipients had comparable immunosuppression with cyclosporine A, prednisolone, and azathioprine and comparable numbers of acute rejection, cytomegalovirus reactivation, and antihypertensive therapy. Mean age of pediatric and adult recipients at transplantation was 5 years (range, 1-9 years) and 38 years (range, 25-60 years), respectively.
The calculated glomerular filtration rate (GFR) corrected to body surface area was not different in adult and pediatric recipients. Initial absolute GFR was significantly lower in pediatric recipients (27 mL/ min; range, 17-38 mL/min) than in adult recipients (54 mL/min; range, 25-74 mL/min) (P <0.05) and remained lower in the following years. Initially, pediatric donor kidneys transplanted into pediatric recipients showed a lower absolute GFR than those transplanted into adults, however, approaching the GFR in adult recipients later. Adult donor kidneys transplanted into pediatric recipients showed a persistently lower absolute GFR in children compared with those transplanted into adult recipients.
The authors conclude that adult donor kidneys in pediatric recipients decrease GFR in the early stages and lack an increase in GFR with growth of the child.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15114083</pmid><doi>10.1097/01.TP.0000120099.92220.7A</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Biological and medical sciences Child Child, Preschool Combined surgery. Multiple transplantations Cytomegalovirus Europe Female Glomerular Filtration Rate Humans Infant Kidney Transplantation - physiology Male Medical sciences Middle Aged Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue and Organ Procurement Tissue Donors |
| title | Renal allograft function in matched pediatric and adult recipient pairs of the same donor |
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