The relationship of intracoronary stent placement following thrombolytic therapy to tissue level Perfusion
Stenting has been shown to improve lumen diameters and thereby improve epicardial blood flow, but the impact of stent placement on tissue level perfusion has not been well characterized. Data were drawn from the LIMIT trial of rhuMAb CD18 (anti WBC antibody) in acute myocardial infarction (AMI). Adj...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2002-04, Vol.13 (2), p.63-68 |
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| container_title | Journal of thrombosis and thrombolysis |
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| creator | GIBSON, C. Michael FRISCH, Daniel MURPHY, Sabina A GOURLAY, Steven G GIBBONS, Raymond BARAN, Kenneth W NGUYEN, Michel PALMERI, Sebastian BARRON, Hal V |
| description | Stenting has been shown to improve lumen diameters and thereby improve epicardial blood flow, but the impact of stent placement on tissue level perfusion has not been well characterized.
Data were drawn from the LIMIT trial of rhuMAb CD18 (anti WBC antibody) in acute myocardial infarction (AMI). Adjunctive/rescue stenting was performed at the discretion of the investigator. The TIMI Myocardial Perfusion Grade (TMPG) was assessed and digital subtraction angiography (DSA) was used to quantify brightness of the myocardial blush.
TIMI 3 flow was 54.2% (64/118) before stent placement, and improved to 87.2% (102/117, p < 0.001) following stent placement. Likewise, Corrected TIMI Frame Counts (CTFCs) improved from medians of 37.6 to 21 (p < 0.001). By DSA, the rate of growth in brightness also tended to be greater after stenting (2.3 +/- 0.4 Gray/sec, n = 54 vs 3.1 +/- 0.3, n = 54, p = 0.07). The incidence of TMPG 0 decreased following stent placement (25.2% (29/118) vs 14.3% (16/118), p = 0.03) and the incidence of a stain in the myocardium (TMPG 1) increased (13.5% (16/118) vs 28.6% (34/118), p = 0.004).
Adjunctive stenting following thrombolytic administration in AMI improves epicardial TIMI 3 flow and TIMI frame counts as well as dye inflow into the myocardium: TMPG 0 is reduced and myocardial blush measured quantitatively by DSA tends to be brighter. However, more TMPG 1 or dye staining was present on next injection, suggesting dye outflow may be impaired. |
| doi_str_mv | 10.1023/A:1016253028348 |
| format | Article |
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Data were drawn from the LIMIT trial of rhuMAb CD18 (anti WBC antibody) in acute myocardial infarction (AMI). Adjunctive/rescue stenting was performed at the discretion of the investigator. The TIMI Myocardial Perfusion Grade (TMPG) was assessed and digital subtraction angiography (DSA) was used to quantify brightness of the myocardial blush.
TIMI 3 flow was 54.2% (64/118) before stent placement, and improved to 87.2% (102/117, p < 0.001) following stent placement. Likewise, Corrected TIMI Frame Counts (CTFCs) improved from medians of 37.6 to 21 (p < 0.001). By DSA, the rate of growth in brightness also tended to be greater after stenting (2.3 +/- 0.4 Gray/sec, n = 54 vs 3.1 +/- 0.3, n = 54, p = 0.07). The incidence of TMPG 0 decreased following stent placement (25.2% (29/118) vs 14.3% (16/118), p = 0.03) and the incidence of a stain in the myocardium (TMPG 1) increased (13.5% (16/118) vs 28.6% (34/118), p = 0.004).
Adjunctive stenting following thrombolytic administration in AMI improves epicardial TIMI 3 flow and TIMI frame counts as well as dye inflow into the myocardium: TMPG 0 is reduced and myocardial blush measured quantitatively by DSA tends to be brighter. However, more TMPG 1 or dye staining was present on next injection, suggesting dye outflow may be impaired.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1023/A:1016253028348</identifier><identifier>PMID: 12101381</identifier><identifier>CODEN: JTTHFF</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Blood Flow Velocity ; Cardiology. Vascular system ; Coronary Angiography - methods ; Coronary Circulation ; Coronary heart disease ; Heart ; Humans ; Image Interpretation, Computer-Assisted ; Medical sciences ; Myocardial Reperfusion - methods ; Stents ; Thrombolytic Therapy ; Treatment Outcome</subject><ispartof>Journal of thrombosis and thrombolysis, 2002-04, Vol.13 (2), p.63-68</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Apr 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-724ba4fd8cfa62859092a62b1f000a7fe06c838446ba6612122623d4d5bc10d43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13802204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12101381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIBSON, C. Michael</creatorcontrib><creatorcontrib>FRISCH, Daniel</creatorcontrib><creatorcontrib>MURPHY, Sabina A</creatorcontrib><creatorcontrib>GOURLAY, Steven G</creatorcontrib><creatorcontrib>GIBBONS, Raymond</creatorcontrib><creatorcontrib>BARAN, Kenneth W</creatorcontrib><creatorcontrib>NGUYEN, Michel</creatorcontrib><creatorcontrib>PALMERI, Sebastian</creatorcontrib><creatorcontrib>BARRON, Hal V</creatorcontrib><creatorcontrib>LIMIT Study Group</creatorcontrib><title>The relationship of intracoronary stent placement following thrombolytic therapy to tissue level Perfusion</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><description>Stenting has been shown to improve lumen diameters and thereby improve epicardial blood flow, but the impact of stent placement on tissue level perfusion has not been well characterized.
Data were drawn from the LIMIT trial of rhuMAb CD18 (anti WBC antibody) in acute myocardial infarction (AMI). Adjunctive/rescue stenting was performed at the discretion of the investigator. The TIMI Myocardial Perfusion Grade (TMPG) was assessed and digital subtraction angiography (DSA) was used to quantify brightness of the myocardial blush.
TIMI 3 flow was 54.2% (64/118) before stent placement, and improved to 87.2% (102/117, p < 0.001) following stent placement. Likewise, Corrected TIMI Frame Counts (CTFCs) improved from medians of 37.6 to 21 (p < 0.001). By DSA, the rate of growth in brightness also tended to be greater after stenting (2.3 +/- 0.4 Gray/sec, n = 54 vs 3.1 +/- 0.3, n = 54, p = 0.07). The incidence of TMPG 0 decreased following stent placement (25.2% (29/118) vs 14.3% (16/118), p = 0.03) and the incidence of a stain in the myocardium (TMPG 1) increased (13.5% (16/118) vs 28.6% (34/118), p = 0.004).
Adjunctive stenting following thrombolytic administration in AMI improves epicardial TIMI 3 flow and TIMI frame counts as well as dye inflow into the myocardium: TMPG 0 is reduced and myocardial blush measured quantitatively by DSA tends to be brighter. However, more TMPG 1 or dye staining was present on next injection, suggesting dye outflow may be impaired.</description><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Circulation</subject><subject>Coronary heart disease</subject><subject>Heart</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Medical sciences</subject><subject>Myocardial Reperfusion - methods</subject><subject>Stents</subject><subject>Thrombolytic Therapy</subject><subject>Treatment Outcome</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkM1LxDAQxYMouq6evUkQ9FbNV9PU2yJ-gaAHBW8lTRM3S9rUJFX2vzfiiuBpZpjfPN4bAI4wOseI0IvFJUaYk5IiIigTW2CGy4oWFSOv22CGalIXeVfugf0YVwihukZkF-xhks-owDOwel5qGLSTyfohLu0IvYF2SEEqH_wgwxrGpIcERyeV7r87453zn3Z4g2kZfN96t05W5UEHOa5h8jDZGCcNnf7QDj7pYKaY1Q_AjpEu6sNNnYOXm-vnq7vi4fH2_mrxUCiKUSoqwlrJTCeUkZyIss4pctNik_3LymjElaCCMd5KznMSQjihHevKVmHUMToHZz-6Y_Dvk46p6W1U2jk5aD_FpsJCYJ7zz8HJP3DlpzBkbw0hiHKSlTN0vIGmttddMwbb5680vy_MwOkGkFFJZ4IclI1_HBUoqzH6BRjIgMY</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>GIBSON, C. 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Michael ; FRISCH, Daniel ; MURPHY, Sabina A ; GOURLAY, Steven G ; GIBBONS, Raymond ; BARAN, Kenneth W ; NGUYEN, Michel ; PALMERI, Sebastian ; BARRON, Hal V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-724ba4fd8cfa62859092a62b1f000a7fe06c838446ba6612122623d4d5bc10d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Circulation</topic><topic>Coronary heart disease</topic><topic>Heart</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Medical sciences</topic><topic>Myocardial Reperfusion - methods</topic><topic>Stents</topic><topic>Thrombolytic Therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIBSON, C. Michael</creatorcontrib><creatorcontrib>FRISCH, Daniel</creatorcontrib><creatorcontrib>MURPHY, Sabina A</creatorcontrib><creatorcontrib>GOURLAY, Steven G</creatorcontrib><creatorcontrib>GIBBONS, Raymond</creatorcontrib><creatorcontrib>BARAN, Kenneth W</creatorcontrib><creatorcontrib>NGUYEN, Michel</creatorcontrib><creatorcontrib>PALMERI, Sebastian</creatorcontrib><creatorcontrib>BARRON, Hal V</creatorcontrib><creatorcontrib>LIMIT Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIBSON, C. Michael</au><au>FRISCH, Daniel</au><au>MURPHY, Sabina A</au><au>GOURLAY, Steven G</au><au>GIBBONS, Raymond</au><au>BARAN, Kenneth W</au><au>NGUYEN, Michel</au><au>PALMERI, Sebastian</au><au>BARRON, Hal V</au><aucorp>LIMIT Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship of intracoronary stent placement following thrombolytic therapy to tissue level Perfusion</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><addtitle>J Thromb Thrombolysis</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>13</volume><issue>2</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><coden>JTTHFF</coden><abstract>Stenting has been shown to improve lumen diameters and thereby improve epicardial blood flow, but the impact of stent placement on tissue level perfusion has not been well characterized.
Data were drawn from the LIMIT trial of rhuMAb CD18 (anti WBC antibody) in acute myocardial infarction (AMI). Adjunctive/rescue stenting was performed at the discretion of the investigator. The TIMI Myocardial Perfusion Grade (TMPG) was assessed and digital subtraction angiography (DSA) was used to quantify brightness of the myocardial blush.
TIMI 3 flow was 54.2% (64/118) before stent placement, and improved to 87.2% (102/117, p < 0.001) following stent placement. Likewise, Corrected TIMI Frame Counts (CTFCs) improved from medians of 37.6 to 21 (p < 0.001). By DSA, the rate of growth in brightness also tended to be greater after stenting (2.3 +/- 0.4 Gray/sec, n = 54 vs 3.1 +/- 0.3, n = 54, p = 0.07). The incidence of TMPG 0 decreased following stent placement (25.2% (29/118) vs 14.3% (16/118), p = 0.03) and the incidence of a stain in the myocardium (TMPG 1) increased (13.5% (16/118) vs 28.6% (34/118), p = 0.004).
Adjunctive stenting following thrombolytic administration in AMI improves epicardial TIMI 3 flow and TIMI frame counts as well as dye inflow into the myocardium: TMPG 0 is reduced and myocardial blush measured quantitatively by DSA tends to be brighter. However, more TMPG 1 or dye staining was present on next injection, suggesting dye outflow may be impaired.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>12101381</pmid><doi>10.1023/A:1016253028348</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Blood Flow Velocity Cardiology. Vascular system Coronary Angiography - methods Coronary Circulation Coronary heart disease Heart Humans Image Interpretation, Computer-Assisted Medical sciences Myocardial Reperfusion - methods Stents Thrombolytic Therapy Treatment Outcome |
| title | The relationship of intracoronary stent placement following thrombolytic therapy to tissue level Perfusion |
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