Selective COX‐2 inhibition prevents proinflammatory cytokine‐induced cartilage damage

Objectives. This study evaluated the in vitro effect of the selective cyclooxygenase‐2 (COX) inhibitor celecoxib on cartilage matrix turnover under normal and inflammatory conditions. Methods. Healthy human articular cartilage tissue alone, in co‐culture with peripheral blood mononuclear cells (PBMC...

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Veröffentlicht in:	British journal of rheumatology 2002-07, Vol.41 (7), p.801-808
Hauptverfasser:	Mastbergen, S. C., Lafeber, F. P. J. G., Bijlsma, J. W. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cartilage Oligomeric Matrix Protein Cartilage, Articular - drug effects Cartilage, Articular - metabolism Celecoxib Cells, Cultured Coculture Techniques Cyclooxygenase Inhibitors - pharmacology Extracellular Matrix Proteins - metabolism Female Glycoproteins - metabolism Human cartilage tissue Humans IL‐1β Inflammation Interleukin-1 - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Matrilin Proteins Medical sciences Pharmacology. Drug treatments Proteoglycan turnover Proteoglycans - biosynthesis Pyrazoles Selective COX‐2 inhibitor Sulfonamides - pharmacology TNF‐α Tumor Necrosis Factor-alpha - pharmacology Up-Regulation
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