Intratracheal Administration Of Glucocorticoids Using Surfactant As A Vehicle

SUMMARY 1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonates. However, systemic administration of glucocorticoids to neonates is associated with significant side‐effects that preclude them as an early intervention to prevent onset of the condition. Co...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2002-08, Vol.29 (8), p.661-665
Hauptverfasser:	Nimmo, Alan J, Carstairs, Jill R, Patole, Sanjay K, Whitehall, John, Davidson, Kate, Vink, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Products chronic lung disease dexamethasone Dexamethasone - administration & dosage Dexamethasone - pharmacokinetics Glucocorticoids - administration & dosage Glucocorticoids - pharmacokinetics instillation Intubation, Intratracheal Lung - drug effects Lung - metabolism Lung Diseases - drug therapy Lung Diseases - metabolism Male Pharmaceutical Vehicles Pulmonary Surfactants - administration & dosage Pulmonary Surfactants - pharmacokinetics Rats Rats, Sprague-Dawley respiratory distress syndrome Surface-Active Agents - administration & dosage Surface-Active Agents - pharmacokinetics
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