Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves
Extraction of cocaine and benzoylecgonine from coca leaves was performed by focused microwave‐assisted extraction (FMAE). Cocaine extraction was optimised with respect to the nature of the extracting solvent, the particle size distribution, the moisture of the sample, the applied microwave power and...
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| Veröffentlicht in: | Phytochemical analysis 2002-05, Vol.13 (3), p.162-169 |
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| container_title | Phytochemical analysis |
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| creator | Brachet, A. Christen, P. Veuthey, J.-L. |
| description | Extraction of cocaine and benzoylecgonine from coca leaves was performed by focused microwave‐assisted extraction (FMAE). Cocaine extraction was optimised with respect to the nature of the extracting solvent, the particle size distribution, the moisture of the sample, the applied microwave power and the radiation time. A central composite design was used to optimise the two latter parameters and to assess the robustness of the extraction method around the best conditions. FMAE generated extracts similar to those obtained by conventional solid–liquid extraction but in a more efficient manner, i.e. 30 s were sufficient to extract cocaine quantitatively from leaves. Analyses of cocaine and benzoylecgonine in coca leaves was carried out by capillary GC‐FID and GC‐MS for peak identification, as well as by capillary electrophoresis with UV detection. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pca.637 |
| format | Article |
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Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>benzoylecgonine</subject><subject>Chemistry Techniques, Analytical - methods</subject><subject>Coca - chemistry</subject><subject>coca leaves</subject><subject>cocaine</subject><subject>Cocaine - analogs & derivatives</subject><subject>Cocaine - isolation & purification</subject><subject>Erythroxylum coca</subject><subject>experimental design</subject><subject>focused microwave-assisted extraction</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Microwaves</subject><subject>Plant Leaves - chemistry</subject><subject>Solvents</subject><issn>0958-0344</issn><issn>1099-1565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMobk7xH0iv9EI6kyZpmssxdArzA1QEb0Kankq1bWazus1fb7YOvfLqhDcPz-G8CB0TPCQYRxczo4cxFTuoT7CUIeEx30V9LHkSYspYDx04946x_5PxPuqRyL8IFn30fGVN6yALqsI0dqG_INTOFW7uI1jOG23mha0DmwfGGl3UEOg6C1Kov-2qBPNm63WWN7baAEEJXuEO0V6uSwdH2znwey6fxtfh9H5yMx5NQ8OIEKFII5poajLNE5zkBnJKGawjyoWMZEwYyzJJUs2xoKmMogjTPE5BcJowzugAnXbeWWM_W3BzVRXOQFnqGmzrlCCJkAkVHjzrQH-kcw3katYUlW5WimC1blD5BlW8IU-2yjatIPvjtpV54LwDFkUJq_886mE86nRhR68rXf7SuvlQsaCCq5e7iaI4Yo-39FVh-gNFQIgq</recordid><startdate>200205</startdate><enddate>200205</enddate><creator>Brachet, A.</creator><creator>Christen, P.</creator><creator>Veuthey, J.-L.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200205</creationdate><title>Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves</title><author>Brachet, A. ; Christen, P. ; Veuthey, J.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4177-7b238a3cda5808fcef334e38a33579296144dd91ba5073b922203f6be75384543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>benzoylecgonine</topic><topic>Chemistry Techniques, Analytical - methods</topic><topic>Coca - chemistry</topic><topic>coca leaves</topic><topic>cocaine</topic><topic>Cocaine - analogs & derivatives</topic><topic>Cocaine - isolation & purification</topic><topic>Erythroxylum coca</topic><topic>experimental design</topic><topic>focused microwave-assisted extraction</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Microwaves</topic><topic>Plant Leaves - chemistry</topic><topic>Solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brachet, A.</creatorcontrib><creatorcontrib>Christen, P.</creatorcontrib><creatorcontrib>Veuthey, J.-L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brachet, A.</au><au>Christen, P.</au><au>Veuthey, J.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves</atitle><jtitle>Phytochemical analysis</jtitle><addtitle>Phytochem. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | benzoylecgonine Chemistry Techniques, Analytical - methods Coca - chemistry coca leaves cocaine Cocaine - analogs & derivatives Cocaine - isolation & purification Erythroxylum coca experimental design focused microwave-assisted extraction Gas Chromatography-Mass Spectrometry Microwaves Plant Leaves - chemistry Solvents |
| title | Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves |
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