Role of p53, CD44V6 and CD57 in Differentiating Between Benign and Malignant Follicular Neoplasms of the Thyroid
The distinction between follicular adenoma (FAD) and follicular carcinoma (FCA) of the thyroid can be particularly challenging in routine practice of diagnostic surgical pathology. It often requires examination of several histologic sections in order to identify the presence of unequivocal capsular...
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| Veröffentlicht in: | In vivo (Athens) 2004-03, Vol.18 (2), p.189-195 |
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| creator | Nasir, Aejaz Catalano, Edison Calafati, Stephanie Cantor, Alan Kaiser, Hans E Coppola, Domenico |
| description | The distinction between follicular adenoma (FAD) and follicular carcinoma (FCA) of the thyroid can be particularly challenging
in routine practice of diagnostic surgical pathology. It often requires examination of several histologic sections in order
to identify the presence of unequivocal capsular and/or vascular invasion. To investigate the role of immunohistochemical
markers in the differential diagnosis of follicular lesions of the thyroid, we studied the pattern of expression of p53, Bcl-2
and of the adhesion molecules CD44V6 and CD57, in 20 FADs and 21 FCAs of the thyroid. Ninety percent of FCAs exhibited strong
nuclear p53 expression. p53 stain was seen in only 15% of FADs (p |
| format | Article |
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in routine practice of diagnostic surgical pathology. It often requires examination of several histologic sections in order
to identify the presence of unequivocal capsular and/or vascular invasion. To investigate the role of immunohistochemical
markers in the differential diagnosis of follicular lesions of the thyroid, we studied the pattern of expression of p53, Bcl-2
and of the adhesion molecules CD44V6 and CD57, in 20 FADs and 21 FCAs of the thyroid. Ninety percent of FCAs exhibited strong
nuclear p53 expression. p53 stain was seen in only 15% of FADs (p<0.0001), and it was weak. Bcl-2 cytoplasmic immunoreactivity
was observed in 57% of FCAs and 60% of FADs (p=1.00). Similarly, membranous CD44V6 staining was seen in 81% of FCAs, but in
only 20% of FADs (p=0.0001). CD57 was present in the cytoplasm of 71% of FCAs and 15% of FADs (p=0.0004). None of the markers
studied correlated with tumor size. The results of this study indicate that immunohistochemical detection of p53, CD44V6 and
CD57 may have practical utility in the differential diagnosis of FCAs from FADs in routine surgical pathology.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 15113046</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adenocarcinoma, Follicular - metabolism ; Adenocarcinoma, Follicular - secondary ; Adenoma - metabolism ; Adenoma - pathology ; Adult ; Aged ; Biomarkers, Tumor - metabolism ; CD57 Antigens - metabolism ; Diagnosis, Differential ; Female ; Glycoproteins - metabolism ; Humans ; Hyaluronan Receptors - metabolism ; Immunoenzyme Techniques ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>In vivo (Athens), 2004-03, Vol.18 (2), p.189-195</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15113046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasir, Aejaz</creatorcontrib><creatorcontrib>Catalano, Edison</creatorcontrib><creatorcontrib>Calafati, Stephanie</creatorcontrib><creatorcontrib>Cantor, Alan</creatorcontrib><creatorcontrib>Kaiser, Hans E</creatorcontrib><creatorcontrib>Coppola, Domenico</creatorcontrib><title>Role of p53, CD44V6 and CD57 in Differentiating Between Benign and Malignant Follicular Neoplasms of the Thyroid</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>The distinction between follicular adenoma (FAD) and follicular carcinoma (FCA) of the thyroid can be particularly challenging
in routine practice of diagnostic surgical pathology. It often requires examination of several histologic sections in order
to identify the presence of unequivocal capsular and/or vascular invasion. To investigate the role of immunohistochemical
markers in the differential diagnosis of follicular lesions of the thyroid, we studied the pattern of expression of p53, Bcl-2
and of the adhesion molecules CD44V6 and CD57, in 20 FADs and 21 FCAs of the thyroid. Ninety percent of FCAs exhibited strong
nuclear p53 expression. p53 stain was seen in only 15% of FADs (p<0.0001), and it was weak. Bcl-2 cytoplasmic immunoreactivity
was observed in 57% of FCAs and 60% of FADs (p=1.00). Similarly, membranous CD44V6 staining was seen in 81% of FCAs, but in
only 20% of FADs (p=0.0001). CD57 was present in the cytoplasm of 71% of FCAs and 15% of FADs (p=0.0004). None of the markers
studied correlated with tumor size. The results of this study indicate that immunohistochemical detection of p53, CD44V6 and
CD57 may have practical utility in the differential diagnosis of FCAs from FADs in routine surgical pathology.</description><subject>Adenocarcinoma, Follicular - metabolism</subject><subject>Adenocarcinoma, Follicular - secondary</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>CD57 Antigens - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Glycoproteins - metabolism</subject><subject>Humans</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10E9LwzAYBvAgipvTryA5iCcLSfOnyVE3p8JUkCneQpqmayRNa9M69u2tOk_Pc_jxwPsegCnOJE4yRuUhmKKUiUQw_D4BJzF-IMQzhNJjMMEMY4Ion4L2pfEWNiVsGbmC8wWlbxzqUIyVZdAFuHBlaTsbeqd7FzbwxvZba8OYwW3CL33Ufqw69HDZeO_M4HUHn2zTeh3r-DPeVxauq13XuOIUHJXaR3u2zxl4Xd6u5_fJ6vnuYX69SqqU8D6hpqSGIU5NilOGjEVcCI7Gw7gsNDIFzllpZS5SWQiTZ8SwgiIic5rnGuGSzMDl327bNZ-Djb2qXTTWex1sM0SVYZFJjskIz_dwyGtbqLZzte526v9HI7j4A5XbVFvXWRVr7f3IiXJfWKhUYSHJN4mGbp4</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Nasir, Aejaz</creator><creator>Catalano, Edison</creator><creator>Calafati, Stephanie</creator><creator>Cantor, Alan</creator><creator>Kaiser, Hans E</creator><creator>Coppola, Domenico</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Role of p53, CD44V6 and CD57 in Differentiating Between Benign and Malignant Follicular Neoplasms of the Thyroid</title><author>Nasir, Aejaz ; Catalano, Edison ; Calafati, Stephanie ; Cantor, Alan ; Kaiser, Hans E ; Coppola, Domenico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h236t-4cf4c5064c21250ce06886075469da0cd1b5fe9b829d8cb73c5d4039b4bba01f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenocarcinoma, Follicular - metabolism</topic><topic>Adenocarcinoma, Follicular - secondary</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>CD57 Antigens - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Glycoproteins - metabolism</topic><topic>Humans</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasir, Aejaz</creatorcontrib><creatorcontrib>Catalano, Edison</creatorcontrib><creatorcontrib>Calafati, Stephanie</creatorcontrib><creatorcontrib>Cantor, Alan</creatorcontrib><creatorcontrib>Kaiser, Hans E</creatorcontrib><creatorcontrib>Coppola, Domenico</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasir, Aejaz</au><au>Catalano, Edison</au><au>Calafati, Stephanie</au><au>Cantor, Alan</au><au>Kaiser, Hans E</au><au>Coppola, Domenico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of p53, CD44V6 and CD57 in Differentiating Between Benign and Malignant Follicular Neoplasms of the Thyroid</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>18</volume><issue>2</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>The distinction between follicular adenoma (FAD) and follicular carcinoma (FCA) of the thyroid can be particularly challenging
in routine practice of diagnostic surgical pathology. It often requires examination of several histologic sections in order
to identify the presence of unequivocal capsular and/or vascular invasion. To investigate the role of immunohistochemical
markers in the differential diagnosis of follicular lesions of the thyroid, we studied the pattern of expression of p53, Bcl-2
and of the adhesion molecules CD44V6 and CD57, in 20 FADs and 21 FCAs of the thyroid. Ninety percent of FCAs exhibited strong
nuclear p53 expression. p53 stain was seen in only 15% of FADs (p<0.0001), and it was weak. Bcl-2 cytoplasmic immunoreactivity
was observed in 57% of FCAs and 60% of FADs (p=1.00). Similarly, membranous CD44V6 staining was seen in 81% of FCAs, but in
only 20% of FADs (p=0.0001). CD57 was present in the cytoplasm of 71% of FCAs and 15% of FADs (p=0.0004). None of the markers
studied correlated with tumor size. The results of this study indicate that immunohistochemical detection of p53, CD44V6 and
CD57 may have practical utility in the differential diagnosis of FCAs from FADs in routine surgical pathology.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>15113046</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma, Follicular - metabolism Adenocarcinoma, Follicular - secondary Adenoma - metabolism Adenoma - pathology Adult Aged Biomarkers, Tumor - metabolism CD57 Antigens - metabolism Diagnosis, Differential Female Glycoproteins - metabolism Humans Hyaluronan Receptors - metabolism Immunoenzyme Techniques Male Middle Aged Proto-Oncogene Proteins c-bcl-2 - metabolism Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Tumor Suppressor Protein p53 - metabolism |
| title | Role of p53, CD44V6 and CD57 in Differentiating Between Benign and Malignant Follicular Neoplasms of the Thyroid |
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