Synthesis of 2,4-Diamino-6-[2‘-O-(ω-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as Potent and Selective Inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductase

Six previously undescribed N-(2,4-diaminopteridin-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy side chains at the 2'-position were synthesized and compared with trimethoprim (TMP) and piritrexim (PTX) as inhibitors of dihydrofolate reductase (DH...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-05, Vol.47 (10), p.2475-2485
Hauptverfasser:	ROSOWSKY, Andre, FU, Hongning, CHAN, David C. M., QUEENER, Sherry F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antiparasitic agents Azepines - chemical synthesis Azepines - chemistry Benzazepines - chemical synthesis Benzazepines - chemistry Biological and medical sciences Folic Acid Antagonists - chemical synthesis Folic Acid Antagonists - chemistry Medical sciences Models, Molecular Mycobacterium avium - enzymology Pharmacology. Drug treatments Pneumocystis carinii - enzymology Pteridines - chemical synthesis Pteridines - chemistry Rats Solubility Structure-Activity Relationship Tetrahydrofolate Dehydrogenase - chemistry Toxoplasma - enzymology Water
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