Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate

The influence of in situ plasticization of chlorpheniramine maleate (CPM) on Eudragit® RS PO from hot-melt extruded matrix tablets, and from compressed granules prepared by thermal processing was investigated. CPM was studied as both a model drug substance and as a solid-state plasticizer for the ac...

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Veröffentlicht in:	International journal of pharmaceutics 2002-07, Vol.241 (2), p.301-310
Hauptverfasser:	Zhu, Yucun, Shah, Navnit H, Malick, A.Waseem, Infeld, Martin H, McGinity, James W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry, Pharmaceutical - methods Chlorpheniramine - chemistry Chlorpheniramine maleate Chromatography, High Pressure Liquid Citrates - chemistry Eudragit® RS PO General pharmacology Hot-melt extrusion Hot-melt granulation Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasticization Plasticizers - chemistry Polymethacrylic Acids - chemistry Technology, Pharmaceutical Triethyl citrate
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