Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences
Purpose To compare signal‐to‐noise ratio (SNR), contrast‐to‐noise (CNR) ratio, and diagnostic accuracy of a newly developed saturation recovery (SR)‐TrueFISP‐two‐dimensional (2D) sequence with an SR‐TurboFLASH‐2D sequence. Materials and Methods In seven healthy subjects and nine patients with corona...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2004-05, Vol.19 (5), p.555-563 |
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| creator | Fenchel, Michael Helber, Uwe Simonetti, Orlando P. Stauder, Norbert I. Kramer, Ulrich Nguyen, Co-Nghi Finn, J. Paul Claussen, Claus D. Miller, Stephan |
| description | Purpose
To compare signal‐to‐noise ratio (SNR), contrast‐to‐noise (CNR) ratio, and diagnostic accuracy of a newly developed saturation recovery (SR)‐TrueFISP‐two‐dimensional (2D) sequence with an SR‐TurboFLASH‐2D sequence.
Materials and Methods
In seven healthy subjects and nine patients with coronary artery disease (CAD), contrast‐enhanced perfusion imaging (with Gd‐DTPA) was performed with SR‐TrueFISP and SR‐TurboFLASH sequences. Hypoperfused areas were assessed qualitatively (scale = 0–4). Furthermore, SNR and CNR were calculated and semiquantitative perfusion parameters were determined from signal intensity (SI) time curves. Standard of reference for patient studies was single‐photon emission computer tomography (SPECT) and angiography.
Results
The perception of perfusion deficits was superior in TrueFISP images (2.6 ± 1.0) than in TurboFLASH (1.4 ± 0.6) (P < 0.001). Phantom measurements yielded increased SNR (143 ± 34%) and CNR (158 ± 64%) values for TrueFISP. In patient/volunteer studies SNR was 61% to 100% higher and signal enhancement was 110% to 115% higher with TrueFISP than with TurboFLASH. Qualitative and semiquantitative assessment of perfusion defects yielded higher sensitivities for detection of perfusion defects with TrueFISP (68% to 78%) than with TurboFLASH (44% to 59%).
Conclusion
SR‐TrueFISP‐2D perfusion imaging provides superior SNR and CNR than TurboFLASH imaging. Moreover, the dynamic range of SIs was found to be higher with TrueFISP, resulting in an increased sensitivity for detection of perfusion defects. J. Magn. Reson. Imaging 2004;19:555–563. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.20050 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71876549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17985239</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4960-294c6bb4e45ae3062fd2bd4341ce639432a4645935557362e785b7e0556dec853</originalsourceid><addsrcrecordid>eNqFkdtu00AQhi0EoqVwwwOgvUIt0pY92-5dlZA2KOWQhIN6s1qvx9UW22t2bUoehnfFIQHu4GpGo2--keZPkqeUnFJC2MvbJrhTRogk95JDKhnDTGbq_tgTyTHNSHqQPIrxlhCS50I-TA6opJRxIg6TH1dD3btYOwuociH2uDMxombjrQmlMzXqIFRDdL5FrjE3rr05QxPfdCa4OM58haLph2D6LRHA-m8QNuh4tTzB6zDAbL56h_s7j0vXQLvVjMpjNj1Bpi3RaonXQyj8bHG-usRsirqhjoAifB2gtRAfJw8qM06e7OtR8mH2aj25xIu3F_PJ-QJbkSuCWS6sKgoBQhrgRLGqZEUpuKAWFM8FZ0YoIXMupUy5YpBmskiBSKlKsJnkR8nznbcLfjwde924aKGuTQt-iDqlWaqkyP8L0jTPJONb8MUOtMHHGKDSXRj_FzaaEr1NTW9T079SG-Fne-tQNFD-RfcxjQDdAXeuhs0_VPr11XL-W4p3Oy728P3PjglftEp5KvWnNxf6Wl7Lz--nM_2R_wS967G1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17985239</pqid></control><display><type>article</type><title>Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fenchel, Michael ; Helber, Uwe ; Simonetti, Orlando P. ; Stauder, Norbert I. ; Kramer, Ulrich ; Nguyen, Co-Nghi ; Finn, J. Paul ; Claussen, Claus D. ; Miller, Stephan</creator><creatorcontrib>Fenchel, Michael ; Helber, Uwe ; Simonetti, Orlando P. ; Stauder, Norbert I. ; Kramer, Ulrich ; Nguyen, Co-Nghi ; Finn, J. Paul ; Claussen, Claus D. ; Miller, Stephan</creatorcontrib><description>Purpose
To compare signal‐to‐noise ratio (SNR), contrast‐to‐noise (CNR) ratio, and diagnostic accuracy of a newly developed saturation recovery (SR)‐TrueFISP‐two‐dimensional (2D) sequence with an SR‐TurboFLASH‐2D sequence.
Materials and Methods
In seven healthy subjects and nine patients with coronary artery disease (CAD), contrast‐enhanced perfusion imaging (with Gd‐DTPA) was performed with SR‐TrueFISP and SR‐TurboFLASH sequences. Hypoperfused areas were assessed qualitatively (scale = 0–4). Furthermore, SNR and CNR were calculated and semiquantitative perfusion parameters were determined from signal intensity (SI) time curves. Standard of reference for patient studies was single‐photon emission computer tomography (SPECT) and angiography.
Results
The perception of perfusion deficits was superior in TrueFISP images (2.6 ± 1.0) than in TurboFLASH (1.4 ± 0.6) (P < 0.001). Phantom measurements yielded increased SNR (143 ± 34%) and CNR (158 ± 64%) values for TrueFISP. In patient/volunteer studies SNR was 61% to 100% higher and signal enhancement was 110% to 115% higher with TrueFISP than with TurboFLASH. Qualitative and semiquantitative assessment of perfusion defects yielded higher sensitivities for detection of perfusion defects with TrueFISP (68% to 78%) than with TurboFLASH (44% to 59%).
Conclusion
SR‐TrueFISP‐2D perfusion imaging provides superior SNR and CNR than TurboFLASH imaging. Moreover, the dynamic range of SIs was found to be higher with TrueFISP, resulting in an increased sensitivity for detection of perfusion defects. J. Magn. Reson. Imaging 2004;19:555–563. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.20050</identifier><identifier>PMID: 15112304</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; CAD ; Coronary Artery Disease - physiopathology ; Coronary Circulation ; FLASH ; Heart - physiopathology ; heart MR ; Humans ; magnetic resonance (MR) ; magnetic resonance (MR) imaging ; magnetic resonance (MR) technology ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; myocardial perfusion ; Phantoms, Imaging ; Reference Values ; Sensitivity and Specificity ; TrueFISP</subject><ispartof>Journal of magnetic resonance imaging, 2004-05, Vol.19 (5), p.555-563</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4960-294c6bb4e45ae3062fd2bd4341ce639432a4645935557362e785b7e0556dec853</citedby><cites>FETCH-LOGICAL-c4960-294c6bb4e45ae3062fd2bd4341ce639432a4645935557362e785b7e0556dec853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.20050$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.20050$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15112304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fenchel, Michael</creatorcontrib><creatorcontrib>Helber, Uwe</creatorcontrib><creatorcontrib>Simonetti, Orlando P.</creatorcontrib><creatorcontrib>Stauder, Norbert I.</creatorcontrib><creatorcontrib>Kramer, Ulrich</creatorcontrib><creatorcontrib>Nguyen, Co-Nghi</creatorcontrib><creatorcontrib>Finn, J. Paul</creatorcontrib><creatorcontrib>Claussen, Claus D.</creatorcontrib><creatorcontrib>Miller, Stephan</creatorcontrib><title>Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To compare signal‐to‐noise ratio (SNR), contrast‐to‐noise (CNR) ratio, and diagnostic accuracy of a newly developed saturation recovery (SR)‐TrueFISP‐two‐dimensional (2D) sequence with an SR‐TurboFLASH‐2D sequence.
Materials and Methods
In seven healthy subjects and nine patients with coronary artery disease (CAD), contrast‐enhanced perfusion imaging (with Gd‐DTPA) was performed with SR‐TrueFISP and SR‐TurboFLASH sequences. Hypoperfused areas were assessed qualitatively (scale = 0–4). Furthermore, SNR and CNR were calculated and semiquantitative perfusion parameters were determined from signal intensity (SI) time curves. Standard of reference for patient studies was single‐photon emission computer tomography (SPECT) and angiography.
Results
The perception of perfusion deficits was superior in TrueFISP images (2.6 ± 1.0) than in TurboFLASH (1.4 ± 0.6) (P < 0.001). Phantom measurements yielded increased SNR (143 ± 34%) and CNR (158 ± 64%) values for TrueFISP. In patient/volunteer studies SNR was 61% to 100% higher and signal enhancement was 110% to 115% higher with TrueFISP than with TurboFLASH. Qualitative and semiquantitative assessment of perfusion defects yielded higher sensitivities for detection of perfusion defects with TrueFISP (68% to 78%) than with TurboFLASH (44% to 59%).
Conclusion
SR‐TrueFISP‐2D perfusion imaging provides superior SNR and CNR than TurboFLASH imaging. Moreover, the dynamic range of SIs was found to be higher with TrueFISP, resulting in an increased sensitivity for detection of perfusion defects. J. Magn. Reson. Imaging 2004;19:555–563. © 2004 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>CAD</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Circulation</subject><subject>FLASH</subject><subject>Heart - physiopathology</subject><subject>heart MR</subject><subject>Humans</subject><subject>magnetic resonance (MR)</subject><subject>magnetic resonance (MR) imaging</subject><subject>magnetic resonance (MR) technology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myocardial perfusion</subject><subject>Phantoms, Imaging</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>TrueFISP</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtu00AQhi0EoqVwwwOgvUIt0pY92-5dlZA2KOWQhIN6s1qvx9UW22t2bUoehnfFIQHu4GpGo2--keZPkqeUnFJC2MvbJrhTRogk95JDKhnDTGbq_tgTyTHNSHqQPIrxlhCS50I-TA6opJRxIg6TH1dD3btYOwuociH2uDMxombjrQmlMzXqIFRDdL5FrjE3rr05QxPfdCa4OM58haLph2D6LRHA-m8QNuh4tTzB6zDAbL56h_s7j0vXQLvVjMpjNj1Bpi3RaonXQyj8bHG-usRsirqhjoAifB2gtRAfJw8qM06e7OtR8mH2aj25xIu3F_PJ-QJbkSuCWS6sKgoBQhrgRLGqZEUpuKAWFM8FZ0YoIXMupUy5YpBmskiBSKlKsJnkR8nznbcLfjwde924aKGuTQt-iDqlWaqkyP8L0jTPJONb8MUOtMHHGKDSXRj_FzaaEr1NTW9T079SG-Fne-tQNFD-RfcxjQDdAXeuhs0_VPr11XL-W4p3Oy728P3PjglftEp5KvWnNxf6Wl7Lz--nM_2R_wS967G1</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Fenchel, Michael</creator><creator>Helber, Uwe</creator><creator>Simonetti, Orlando P.</creator><creator>Stauder, Norbert I.</creator><creator>Kramer, Ulrich</creator><creator>Nguyen, Co-Nghi</creator><creator>Finn, J. Paul</creator><creator>Claussen, Claus D.</creator><creator>Miller, Stephan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200405</creationdate><title>Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences</title><author>Fenchel, Michael ; Helber, Uwe ; Simonetti, Orlando P. ; Stauder, Norbert I. ; Kramer, Ulrich ; Nguyen, Co-Nghi ; Finn, J. Paul ; Claussen, Claus D. ; Miller, Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4960-294c6bb4e45ae3062fd2bd4341ce639432a4645935557362e785b7e0556dec853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>CAD</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Circulation</topic><topic>FLASH</topic><topic>Heart - physiopathology</topic><topic>heart MR</topic><topic>Humans</topic><topic>magnetic resonance (MR)</topic><topic>magnetic resonance (MR) imaging</topic><topic>magnetic resonance (MR) technology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myocardial perfusion</topic><topic>Phantoms, Imaging</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>TrueFISP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fenchel, Michael</creatorcontrib><creatorcontrib>Helber, Uwe</creatorcontrib><creatorcontrib>Simonetti, Orlando P.</creatorcontrib><creatorcontrib>Stauder, Norbert I.</creatorcontrib><creatorcontrib>Kramer, Ulrich</creatorcontrib><creatorcontrib>Nguyen, Co-Nghi</creatorcontrib><creatorcontrib>Finn, J. Paul</creatorcontrib><creatorcontrib>Claussen, Claus D.</creatorcontrib><creatorcontrib>Miller, Stephan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fenchel, Michael</au><au>Helber, Uwe</au><au>Simonetti, Orlando P.</au><au>Stauder, Norbert I.</au><au>Kramer, Ulrich</au><au>Nguyen, Co-Nghi</au><au>Finn, J. Paul</au><au>Claussen, Claus D.</au><au>Miller, Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2004-05</date><risdate>2004</risdate><volume>19</volume><issue>5</issue><spage>555</spage><epage>563</epage><pages>555-563</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To compare signal‐to‐noise ratio (SNR), contrast‐to‐noise (CNR) ratio, and diagnostic accuracy of a newly developed saturation recovery (SR)‐TrueFISP‐two‐dimensional (2D) sequence with an SR‐TurboFLASH‐2D sequence.
Materials and Methods
In seven healthy subjects and nine patients with coronary artery disease (CAD), contrast‐enhanced perfusion imaging (with Gd‐DTPA) was performed with SR‐TrueFISP and SR‐TurboFLASH sequences. Hypoperfused areas were assessed qualitatively (scale = 0–4). Furthermore, SNR and CNR were calculated and semiquantitative perfusion parameters were determined from signal intensity (SI) time curves. Standard of reference for patient studies was single‐photon emission computer tomography (SPECT) and angiography.
Results
The perception of perfusion deficits was superior in TrueFISP images (2.6 ± 1.0) than in TurboFLASH (1.4 ± 0.6) (P < 0.001). Phantom measurements yielded increased SNR (143 ± 34%) and CNR (158 ± 64%) values for TrueFISP. In patient/volunteer studies SNR was 61% to 100% higher and signal enhancement was 110% to 115% higher with TrueFISP than with TurboFLASH. Qualitative and semiquantitative assessment of perfusion defects yielded higher sensitivities for detection of perfusion defects with TrueFISP (68% to 78%) than with TurboFLASH (44% to 59%).
Conclusion
SR‐TrueFISP‐2D perfusion imaging provides superior SNR and CNR than TurboFLASH imaging. Moreover, the dynamic range of SIs was found to be higher with TrueFISP, resulting in an increased sensitivity for detection of perfusion defects. J. Magn. Reson. Imaging 2004;19:555–563. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15112304</pmid><doi>10.1002/jmri.20050</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged CAD Coronary Artery Disease - physiopathology Coronary Circulation FLASH Heart - physiopathology heart MR Humans magnetic resonance (MR) magnetic resonance (MR) imaging magnetic resonance (MR) technology Magnetic Resonance Imaging - methods Male Middle Aged myocardial perfusion Phantoms, Imaging Reference Values Sensitivity and Specificity TrueFISP |
| title | Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences |
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