Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes
The expression of 36 genes that have been linked to the outcomes in diffuse large-B-cell lymphoma was studied with the use of real-time polymerase chain reaction in biopsy specimens of the lymphoma. The pattern of expression of a group of 6 of the 36 genes correlated significantly with survival. The...
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| Veröffentlicht in: | The New England journal of medicine 2004-04, Vol.350 (18), p.1828-1837 |
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| container_title | The New England journal of medicine |
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| creator | Lossos, Izidore S Czerwinski, Debra K Alizadeh, Ash A Wechser, Mark A Tibshirani, Rob Botstein, David Levy, Ronald |
| description | The expression of 36 genes that have been linked to the outcomes in diffuse large-B-cell lymphoma was studied with the use of real-time polymerase chain reaction in biopsy specimens of the lymphoma. The pattern of expression of a group of 6 of the 36 genes correlated significantly with survival.
The pattern of expression of a group of 6 of the 36 genes correlated with survival.
The most common type of lymphoma in adults, diffuse large-B-cell lymphoma, has an annual incidence in the United States of more than 25,000 cases and accounts for 30 to 40 percent of cases of non-Hodgkin's lymphomas.
1
Combination chemotherapy has transformed diffuse large-B-cell lymphoma from a universally fatal disease to a potentially curable one, but less than half of all patients are cured.
2
The International Prognostic Index (IPI), a well-established predictor of outcome in diffuse large-B-cell lymphoma, is based on five clinical characteristics (age, tumor stage, serum lactate dehydrogenase concentration, performance status, and number of extranodal disease sites).
3
However, the outcome . . . |
| doi_str_mv | 10.1056/NEJMoa032520 |
| format | Article |
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The pattern of expression of a group of 6 of the 36 genes correlated with survival.
The most common type of lymphoma in adults, diffuse large-B-cell lymphoma, has an annual incidence in the United States of more than 25,000 cases and accounts for 30 to 40 percent of cases of non-Hodgkin's lymphomas.
1
Combination chemotherapy has transformed diffuse large-B-cell lymphoma from a universally fatal disease to a potentially curable one, but less than half of all patients are cured.
2
The International Prognostic Index (IPI), a well-established predictor of outcome in diffuse large-B-cell lymphoma, is based on five clinical characteristics (age, tumor stage, serum lactate dehydrogenase concentration, performance status, and number of extranodal disease sites).
3
However, the outcome . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa032520</identifier><identifier>PMID: 15115829</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Aged ; Analysis of Variance ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Cells ; Clinical trials ; DNA polymerase ; Female ; Gene Expression ; Gene Expression Profiling ; General aspects ; Genes ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma ; Lymphoma, B-Cell - drug therapy ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - mortality ; Lymphoma, Large B-Cell, Diffuse - drug therapy ; Lymphoma, Large B-Cell, Diffuse - genetics ; Lymphoma, Large B-Cell, Diffuse - mortality ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Models, Genetic ; Models, Statistical ; Multivariate Analysis ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Analysis</subject><ispartof>The New England journal of medicine, 2004-04, Vol.350 (18), p.1828-1837</ispartof><rights>Copyright © 2004 Massachusetts Medical Society. All rights reserved.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-8cffe58c457f4175d0755d1a4772be4b7f1f1000e701c818331d224f0f0270253</citedby><cites>FETCH-LOGICAL-c675t-8cffe58c457f4175d0755d1a4772be4b7f1f1000e701c818331d224f0f0270253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa032520$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa032520$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15695645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15115829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lossos, Izidore S</creatorcontrib><creatorcontrib>Czerwinski, Debra K</creatorcontrib><creatorcontrib>Alizadeh, Ash A</creatorcontrib><creatorcontrib>Wechser, Mark A</creatorcontrib><creatorcontrib>Tibshirani, Rob</creatorcontrib><creatorcontrib>Botstein, David</creatorcontrib><creatorcontrib>Levy, Ronald</creatorcontrib><title>Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The expression of 36 genes that have been linked to the outcomes in diffuse large-B-cell lymphoma was studied with the use of real-time polymerase chain reaction in biopsy specimens of the lymphoma. The pattern of expression of a group of 6 of the 36 genes correlated significantly with survival.
The pattern of expression of a group of 6 of the 36 genes correlated with survival.
The most common type of lymphoma in adults, diffuse large-B-cell lymphoma, has an annual incidence in the United States of more than 25,000 cases and accounts for 30 to 40 percent of cases of non-Hodgkin's lymphomas.
1
Combination chemotherapy has transformed diffuse large-B-cell lymphoma from a universally fatal disease to a potentially curable one, but less than half of all patients are cured.
2
The International Prognostic Index (IPI), a well-established predictor of outcome in diffuse large-B-cell lymphoma, is based on five clinical characteristics (age, tumor stage, serum lactate dehydrogenase concentration, performance status, and number of extranodal disease sites).
3
However, the outcome . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cells</subject><subject>Clinical trials</subject><subject>DNA polymerase</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>General aspects</subject><subject>Genes</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell - drug therapy</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, B-Cell - mortality</subject><subject>Lymphoma, Large B-Cell, Diffuse - drug therapy</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Models, Genetic</subject><subject>Models, Statistical</subject><subject>Multivariate Analysis</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Survival Analysis</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c1PFDEYBvCGaGBFb55NY8RwcLRvP6adI6wLalYgUW8kk27nrXQzH2u7Q-C_t2SXSAzRXnr59en75iHkJbD3wFT54Wz25etgmeCKsx0yASVEISUrn5AJY9wUUldijzxLacnyAVntkj1QAMrwakIuLyI2wa3D0NPB029jvA7XtqWhpx-D92NCOrfxJxbHxRTbls5vu9XV0Fl6bBM2NL9aXyGd3awipnQfEm7oKfaYnpOn3rYJX2zvffLjZPZ9-qmYn59-nh7NC1dqtS6M8x6VcVJpL0GrhmmlGrBSa75AudAePOTZUTNwBowQ0HAuPfOMa8aV2CdvN7mrOPwaMa3rLiSXx7U9DmOqNRhdCikzPPwnzE4ZqRT8PxN0aVSpdYav_4LLYYx93rfmXFSSCSkyerdBLg4pRfT1KobOxtsaWH1XY_2wxsxfbTPHRYfNH7ztLYODLbDJ2dZH27uQHriyUqW82-LNxnVdqntcdo__9xuN96xp</recordid><startdate>20040429</startdate><enddate>20040429</enddate><creator>Lossos, Izidore S</creator><creator>Czerwinski, Debra K</creator><creator>Alizadeh, Ash A</creator><creator>Wechser, Mark A</creator><creator>Tibshirani, Rob</creator><creator>Botstein, David</creator><creator>Levy, Ronald</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040429</creationdate><title>Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes</title><author>Lossos, Izidore S ; Czerwinski, Debra K ; Alizadeh, Ash A ; Wechser, Mark A ; Tibshirani, Rob ; Botstein, David ; Levy, Ronald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c675t-8cffe58c457f4175d0755d1a4772be4b7f1f1000e701c818331d224f0f0270253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cells</topic><topic>Clinical trials</topic><topic>DNA polymerase</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Expression Profiling</topic><topic>General aspects</topic><topic>Genes</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. 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Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lossos, Izidore S</au><au>Czerwinski, Debra K</au><au>Alizadeh, Ash A</au><au>Wechser, Mark A</au><au>Tibshirani, Rob</au><au>Botstein, David</au><au>Levy, Ronald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2004-04-29</date><risdate>2004</risdate><volume>350</volume><issue>18</issue><spage>1828</spage><epage>1837</epage><pages>1828-1837</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>The expression of 36 genes that have been linked to the outcomes in diffuse large-B-cell lymphoma was studied with the use of real-time polymerase chain reaction in biopsy specimens of the lymphoma. The pattern of expression of a group of 6 of the 36 genes correlated significantly with survival.
The pattern of expression of a group of 6 of the 36 genes correlated with survival.
The most common type of lymphoma in adults, diffuse large-B-cell lymphoma, has an annual incidence in the United States of more than 25,000 cases and accounts for 30 to 40 percent of cases of non-Hodgkin's lymphomas.
1
Combination chemotherapy has transformed diffuse large-B-cell lymphoma from a universally fatal disease to a potentially curable one, but less than half of all patients are cured.
2
The International Prognostic Index (IPI), a well-established predictor of outcome in diffuse large-B-cell lymphoma, is based on five clinical characteristics (age, tumor stage, serum lactate dehydrogenase concentration, performance status, and number of extranodal disease sites).
3
However, the outcome . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>15115829</pmid><doi>10.1056/NEJMoa032520</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2004-04, Vol.350 (18), p.1828-1837 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Adult Aged Analysis of Variance Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cells Clinical trials DNA polymerase Female Gene Expression Gene Expression Profiling General aspects Genes Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - genetics Lymphoma, B-Cell - mortality Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Male Medical sciences Medical treatment Middle Aged Models, Genetic Models, Statistical Multivariate Analysis Oligonucleotide Array Sequence Analysis Prognosis Reverse Transcriptase Polymerase Chain Reaction Survival Analysis |
| title | Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes |
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