A rabbit ear flap perfusion experiment to evaluate the percutaneous absorption of drugs

A rabbit ear flap single-pass perfusion system was examined as an experimental method for studying the relationship between the physiological conditions of tissues and drug disposition after topical applications. Tyrode solutions containing bovine serum albumin (BSA) and sucrose or flurbiprofen (FP)...

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Veröffentlicht in:	International journal of pharmaceutics 2004-05, Vol.276 (1), p.29-40
Hauptverfasser:	Seki, Toshinobu, Hosoya, Osamu, Yamazaki, Tsuyoshi, Sato, Takeshi, Saso, Yuko, Juni, Kazuhiko, Morimoto, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Biological and medical sciences Bradykinin Bradykinin - pharmacology Chemistry, Pharmaceutical Ear Flurbiprofen Flurbiprofen - administration & dosage Flurbiprofen - metabolism Flurbiprofen - pharmacokinetics General pharmacology Isotonic Solutions - pharmacology Male Medical sciences Perfusion Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protein Binding Rabbit ear Rabbits Skin Absorption - drug effects Tissue Distribution Topical application
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