The influence of clinical information on the accuracy of diagnostic mammography
This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms. Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women sho...
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| Veröffentlicht in: | Breast cancer research and treatment 2004-06, Vol.85 (3), p.223-228 |
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| creator | HOUSSAMI, Nehmat IRWIG, Les SIMPSON, Judy M MCKESSAR, Merran BLOME, Steven NOAKES, Jennie |
| description | This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms.
Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women shown to have breast cancer and 240 age-matched women shown not to have cancer. Mammography films were prospectively reported by two radiologists independently of each other in a blinded manner and without knowledge of any clinical information. The films were then re-read with information about the type and site of symptoms (and without knowledge of the level of suspicion of cancer on clinical examination). The accuracy of reading with and without information on symptoms was compared using sensitivity and specificity and receiver operating characteristic (ROC) curves. The effect of age on changes in test accuracy was examined.
Reporting the mammogram with knowledge of clinical information (compared to without any information) significantly improved sensitivity (75.8 vs. 71.3%, P = 0.003) for one radiologist, with a non-significant reduction in specificity (85.4 vs. 87.1%, P = 0.22). For the other radiologist, it resulted in non-significant improvement in both sensitivity (75.4 vs. 73.8%, P = 0.13) and specificity (89.2 vs. 87.9%, P = 0.25). Age did not have a statistically significant effect on changes in test accuracy in our data. ROC curves for both radiologists showed that reporting mammography with knowledge of clinical information resulted in small (about 2%) but significant improvement in overall test accuracy.
Our findings support the provision of clinical information relating to patients' presentation to radiologists reporting diagnostic mammography. |
| doi_str_mv | 10.1023/B:BREA.0000025416.66632.84 |
| format | Article |
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Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women shown to have breast cancer and 240 age-matched women shown not to have cancer. Mammography films were prospectively reported by two radiologists independently of each other in a blinded manner and without knowledge of any clinical information. The films were then re-read with information about the type and site of symptoms (and without knowledge of the level of suspicion of cancer on clinical examination). The accuracy of reading with and without information on symptoms was compared using sensitivity and specificity and receiver operating characteristic (ROC) curves. The effect of age on changes in test accuracy was examined.
Reporting the mammogram with knowledge of clinical information (compared to without any information) significantly improved sensitivity (75.8 vs. 71.3%, P = 0.003) for one radiologist, with a non-significant reduction in specificity (85.4 vs. 87.1%, P = 0.22). For the other radiologist, it resulted in non-significant improvement in both sensitivity (75.4 vs. 73.8%, P = 0.13) and specificity (89.2 vs. 87.9%, P = 0.25). Age did not have a statistically significant effect on changes in test accuracy in our data. ROC curves for both radiologists showed that reporting mammography with knowledge of clinical information resulted in small (about 2%) but significant improvement in overall test accuracy.
Our findings support the provision of clinical information relating to patients' presentation to radiologists reporting diagnostic mammography.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/B:BREA.0000025416.66632.84</identifier><identifier>PMID: 15111760</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Antineoplastic agents ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - diagnostic imaging ; Cancer research ; Case-Control Studies ; Female ; Humans ; Logistic Models ; Mammography ; Mammography - methods ; Matched-Pair Analysis ; Medical History Taking ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prospective Studies ; Radiology ; ROC Curve ; Sensitivity and Specificity ; Single-Blind Method ; Tumors</subject><ispartof>Breast cancer research and treatment, 2004-06, Vol.85 (3), p.223-228</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Kluwer Academic Publishers</rights><rights>Copyright Kluwer Academic Publishers Jun 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-7c36aabce875a7b307160a80c104e7e4948805878b4638b0738b8568121824ec3</citedby><cites>FETCH-LOGICAL-c429t-7c36aabce875a7b307160a80c104e7e4948805878b4638b0738b8568121824ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15710616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15111760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOUSSAMI, Nehmat</creatorcontrib><creatorcontrib>IRWIG, Les</creatorcontrib><creatorcontrib>SIMPSON, Judy M</creatorcontrib><creatorcontrib>MCKESSAR, Merran</creatorcontrib><creatorcontrib>BLOME, Steven</creatorcontrib><creatorcontrib>NOAKES, Jennie</creatorcontrib><title>The influence of clinical information on the accuracy of diagnostic mammography</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms.
Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women shown to have breast cancer and 240 age-matched women shown not to have cancer. Mammography films were prospectively reported by two radiologists independently of each other in a blinded manner and without knowledge of any clinical information. The films were then re-read with information about the type and site of symptoms (and without knowledge of the level of suspicion of cancer on clinical examination). The accuracy of reading with and without information on symptoms was compared using sensitivity and specificity and receiver operating characteristic (ROC) curves. The effect of age on changes in test accuracy was examined.
Reporting the mammogram with knowledge of clinical information (compared to without any information) significantly improved sensitivity (75.8 vs. 71.3%, P = 0.003) for one radiologist, with a non-significant reduction in specificity (85.4 vs. 87.1%, P = 0.22). For the other radiologist, it resulted in non-significant improvement in both sensitivity (75.4 vs. 73.8%, P = 0.13) and specificity (89.2 vs. 87.9%, P = 0.25). Age did not have a statistically significant effect on changes in test accuracy in our data. ROC curves for both radiologists showed that reporting mammography with knowledge of clinical information resulted in small (about 2%) but significant improvement in overall test accuracy.
Our findings support the provision of clinical information relating to patients' presentation to radiologists reporting diagnostic mammography.</description><subject>Adult</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Cancer research</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Mammography</subject><subject>Mammography - methods</subject><subject>Matched-Pair Analysis</subject><subject>Medical History Taking</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Single-Blind Method</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkG1LwzAQgIMoOl_-gpSBfuvMJWmS-s2JbzAYiH4OaZbOjLaZSfth_95UB4rHcQfHc8nxIDQFPANM6M38dv76cDfDY5CCAZ9xzimZSXaAJlAImgsC4hBNMHCRc4n5CTqNcZPwUuDyGJ1AAQCC4wlavn3YzHV1M9jO2MzXmWlc54xuxqkPre6d77KUfQK1MUPQZjdyK6fXnY-9M1mr29avg95-7M7RUa2baC_2_Qy9Pz683T_ni-XTy_3dIjeMlH0uDOVaV8ZKUWhRUSyAYy2xAcyssKxkUuJCClkxTmWFRSqy4BIISMKsoWfo-ufdbfCfg429al00tml0Z_0QlQApOFBI4PQfuPFD6NJtigBhDEpCE3T7A5ngYwy2VtvgWh12CrAanau5Gp2rX-fq27mSLC1f7n8Yqtauflf3khNwtQd0TGLroDvj4h9OAObA6RfyW4iG</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>HOUSSAMI, Nehmat</creator><creator>IRWIG, Les</creator><creator>SIMPSON, Judy M</creator><creator>MCKESSAR, Merran</creator><creator>BLOME, Steven</creator><creator>NOAKES, Jennie</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>The influence of clinical information on the accuracy of diagnostic mammography</title><author>HOUSSAMI, Nehmat ; IRWIG, Les ; SIMPSON, Judy M ; MCKESSAR, Merran ; BLOME, Steven ; NOAKES, Jennie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-7c36aabce875a7b307160a80c104e7e4948805878b4638b0738b8568121824ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Cancer research</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Mammography</topic><topic>Mammography - methods</topic><topic>Matched-Pair Analysis</topic><topic>Medical History Taking</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Single-Blind Method</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOUSSAMI, Nehmat</creatorcontrib><creatorcontrib>IRWIG, Les</creatorcontrib><creatorcontrib>SIMPSON, Judy M</creatorcontrib><creatorcontrib>MCKESSAR, Merran</creatorcontrib><creatorcontrib>BLOME, Steven</creatorcontrib><creatorcontrib>NOAKES, Jennie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOUSSAMI, Nehmat</au><au>IRWIG, Les</au><au>SIMPSON, Judy M</au><au>MCKESSAR, Merran</au><au>BLOME, Steven</au><au>NOAKES, Jennie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of clinical information on the accuracy of diagnostic mammography</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>85</volume><issue>3</issue><spage>223</spage><epage>228</epage><pages>223-228</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms.
Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women shown to have breast cancer and 240 age-matched women shown not to have cancer. Mammography films were prospectively reported by two radiologists independently of each other in a blinded manner and without knowledge of any clinical information. The films were then re-read with information about the type and site of symptoms (and without knowledge of the level of suspicion of cancer on clinical examination). The accuracy of reading with and without information on symptoms was compared using sensitivity and specificity and receiver operating characteristic (ROC) curves. The effect of age on changes in test accuracy was examined.
Reporting the mammogram with knowledge of clinical information (compared to without any information) significantly improved sensitivity (75.8 vs. 71.3%, P = 0.003) for one radiologist, with a non-significant reduction in specificity (85.4 vs. 87.1%, P = 0.22). For the other radiologist, it resulted in non-significant improvement in both sensitivity (75.4 vs. 73.8%, P = 0.13) and specificity (89.2 vs. 87.9%, P = 0.25). Age did not have a statistically significant effect on changes in test accuracy in our data. ROC curves for both radiologists showed that reporting mammography with knowledge of clinical information resulted in small (about 2%) but significant improvement in overall test accuracy.
Our findings support the provision of clinical information relating to patients' presentation to radiologists reporting diagnostic mammography.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>15111760</pmid><doi>10.1023/B:BREA.0000025416.66632.84</doi><tpages>6</tpages></addata></record> |
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| ispartof | Breast cancer research and treatment, 2004-06, Vol.85 (3), p.223-228 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Antineoplastic agents Biological and medical sciences Breast cancer Breast Neoplasms - diagnostic imaging Cancer research Case-Control Studies Female Humans Logistic Models Mammography Mammography - methods Matched-Pair Analysis Medical History Taking Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Radiology ROC Curve Sensitivity and Specificity Single-Blind Method Tumors |
| title | The influence of clinical information on the accuracy of diagnostic mammography |
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