Extracorporeal photochemotherapy for the treatment of exanthematic pityriasis rubra pilaris
Summary Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disease of unknown aetiology that has been categorized into five clinical types based on age at onset, cutaneous features and prognosis. We present a patient with chronic exanthematic type II atypical adult PRP, whose skin status w...
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| Veröffentlicht in: | Clinical and experimental dermatology 2004-05, Vol.29 (3), p.244-246 |
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| container_title | Clinical and experimental dermatology |
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| creator | Haenssle, H. A. Bertsch, H. P. Emmert, S. Wolf, C. Zutt, M. |
| description | Summary
Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disease of unknown aetiology that has been categorized into five clinical types based on age at onset, cutaneous features and prognosis. We present a patient with chronic exanthematic type II atypical adult PRP, whose skin status was significantly improved with monthly extracorporeal photochemotherapy (ECP). Various therapeutic regimens including narrow‐band UV‐B, bath PUVA therapy, systemic fumaric acid esters and systemic cyclosporin had failed. Oral retinoids could not be administered due to a type IIa hyperlipoproteinemia with profound hepatic steatosis and elevated liver transaminases. The observed clinical benefit may encourage future clinical studies analysing the effectiveness of ECP in otherwise unresponsive cases of type II PRP. |
| doi_str_mv | 10.1111/j.1365-2230.2004.01468.x |
| format | Article |
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Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disease of unknown aetiology that has been categorized into five clinical types based on age at onset, cutaneous features and prognosis. We present a patient with chronic exanthematic type II atypical adult PRP, whose skin status was significantly improved with monthly extracorporeal photochemotherapy (ECP). Various therapeutic regimens including narrow‐band UV‐B, bath PUVA therapy, systemic fumaric acid esters and systemic cyclosporin had failed. Oral retinoids could not be administered due to a type IIa hyperlipoproteinemia with profound hepatic steatosis and elevated liver transaminases. The observed clinical benefit may encourage future clinical studies analysing the effectiveness of ECP in otherwise unresponsive cases of type II PRP.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2004.01468.x</identifier><identifier>PMID: 15115502</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Dermatology ; Exanthema - drug therapy ; Exanthema - pathology ; Humans ; Male ; Medical sciences ; Photopheresis ; Pityriasis Rubra Pilaris - drug therapy ; Pityriasis Rubra Pilaris - pathology ; Skin involvement in other diseases. Miscellaneous. General aspects ; Treatment Outcome</subject><ispartof>Clinical and experimental dermatology, 2004-05, Vol.29 (3), p.244-246</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Science Ltd. May 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4608-dc151840fb6ddbb07f962b0a5ceaa0d222abc696adff92a79ae693a2635a23663</citedby><cites>FETCH-LOGICAL-c4608-dc151840fb6ddbb07f962b0a5ceaa0d222abc696adff92a79ae693a2635a23663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15726042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15115502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haenssle, H. A.</creatorcontrib><creatorcontrib>Bertsch, H. P.</creatorcontrib><creatorcontrib>Emmert, S.</creatorcontrib><creatorcontrib>Wolf, C.</creatorcontrib><creatorcontrib>Zutt, M.</creatorcontrib><title>Extracorporeal photochemotherapy for the treatment of exanthematic pityriasis rubra pilaris</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disease of unknown aetiology that has been categorized into five clinical types based on age at onset, cutaneous features and prognosis. We present a patient with chronic exanthematic type II atypical adult PRP, whose skin status was significantly improved with monthly extracorporeal photochemotherapy (ECP). Various therapeutic regimens including narrow‐band UV‐B, bath PUVA therapy, systemic fumaric acid esters and systemic cyclosporin had failed. Oral retinoids could not be administered due to a type IIa hyperlipoproteinemia with profound hepatic steatosis and elevated liver transaminases. The observed clinical benefit may encourage future clinical studies analysing the effectiveness of ECP in otherwise unresponsive cases of type II PRP.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Exanthema - drug therapy</subject><subject>Exanthema - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Photopheresis</subject><subject>Pityriasis Rubra Pilaris - drug therapy</subject><subject>Pityriasis Rubra Pilaris - pathology</subject><subject>Skin involvement in other diseases. Miscellaneous. 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P.</creatorcontrib><creatorcontrib>Emmert, S.</creatorcontrib><creatorcontrib>Wolf, C.</creatorcontrib><creatorcontrib>Zutt, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haenssle, H. A.</au><au>Bertsch, H. P.</au><au>Emmert, S.</au><au>Wolf, C.</au><au>Zutt, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracorporeal photochemotherapy for the treatment of exanthematic pityriasis rubra pilaris</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2004-05</date><risdate>2004</risdate><volume>29</volume><issue>3</issue><spage>244</spage><epage>246</epage><pages>244-246</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Pityriasis rubra pilaris (PRP) is a rare papulosquamous skin disease of unknown aetiology that has been categorized into five clinical types based on age at onset, cutaneous features and prognosis. We present a patient with chronic exanthematic type II atypical adult PRP, whose skin status was significantly improved with monthly extracorporeal photochemotherapy (ECP). Various therapeutic regimens including narrow‐band UV‐B, bath PUVA therapy, systemic fumaric acid esters and systemic cyclosporin had failed. Oral retinoids could not be administered due to a type IIa hyperlipoproteinemia with profound hepatic steatosis and elevated liver transaminases. The observed clinical benefit may encourage future clinical studies analysing the effectiveness of ECP in otherwise unresponsive cases of type II PRP.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15115502</pmid><doi>10.1111/j.1365-2230.2004.01468.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Clinical and experimental dermatology, 2004-05, Vol.29 (3), p.244-246 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Dermatology Exanthema - drug therapy Exanthema - pathology Humans Male Medical sciences Photopheresis Pityriasis Rubra Pilaris - drug therapy Pityriasis Rubra Pilaris - pathology Skin involvement in other diseases. Miscellaneous. General aspects Treatment Outcome |
| title | Extracorporeal photochemotherapy for the treatment of exanthematic pityriasis rubra pilaris |
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