Natural antimycobacterial metabolites: current status
Over the years the introduction of very effective drugs has revolutionized the treatment of tuberculosis. In recent years, however, emerging multiple drug resistance has become a major threat and thus calls for an urgent search for new and effective treatments for this deadly disease. This review is...
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| Veröffentlicht in: | Phytochemistry 2004-04, Vol.65 (8), p.1017-1032 |
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| creator | Okunade, Adewole L. Elvin-Lewis, Memory P.F. Lewis, Walter H. |
| description | Over the years the introduction of very effective drugs has revolutionized the treatment of tuberculosis. In recent years, however, emerging multiple drug resistance has become a major threat and thus calls for an urgent search for new and effective treatments for this deadly disease. This review is complementary to earlier reviews and covers more recent reports of naturally occurring compounds, and in some cases synthetic analogs, largely from plants, fungi and marine organisms that demonstrate significant activity in the in vitro bioassays against
Mycobacterium tuberculosis, and other mycobacterial species. Included also are traditional medicinal uses of specific plants when utilized to treat tuberculosis and other pulmonary diseases.
The review covers current reports of naturally occurring compounds, and in some cases synthetic analogs, largely from plants, fungi and marine organisms that demonstrate significant activity in the in vitro bioassays against
Mycobacterium tuberculosis (MTB), and other species. |
| doi_str_mv | 10.1016/j.phytochem.2004.02.013 |
| format | Article |
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Mycobacterium tuberculosis, and other mycobacterial species. Included also are traditional medicinal uses of specific plants when utilized to treat tuberculosis and other pulmonary diseases.
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Mycobacterium tuberculosis, and other mycobacterial species. Included also are traditional medicinal uses of specific plants when utilized to treat tuberculosis and other pulmonary diseases.
The review covers current reports of naturally occurring compounds, and in some cases synthetic analogs, largely from plants, fungi and marine organisms that demonstrate significant activity in the in vitro bioassays against
Mycobacterium tuberculosis (MTB), and other species.</description><subject>Alkaloids - chemistry</subject><subject>Alkaloids - metabolism</subject><subject>Alkaloids - pharmacology</subject><subject>Antimycobacterial metabolites</subject><subject>Antitubercular Agents - chemistry</subject><subject>Antitubercular Agents - metabolism</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chalcone - chemistry</subject><subject>Chalcone - metabolism</subject><subject>Chalcone - pharmacology</subject><subject>Chromones - chemistry</subject><subject>Chromones - metabolism</subject><subject>Chromones - pharmacology</subject><subject>Coumarins - chemistry</subject><subject>Coumarins - metabolism</subject><subject>Coumarins - pharmacology</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - metabolism</subject><subject>Flavonoids - pharmacology</subject><subject>Fungi</subject><subject>General pharmacology</subject><subject>Marine organisms</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycobacterium tuberculosis</subject><subject>Peptides - chemistry</subject><subject>Peptides - metabolism</subject><subject>Peptides - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenols - chemistry</subject><subject>Phenols - metabolism</subject><subject>Phenols - pharmacology</subject><subject>Plant Preparations - chemistry</subject><subject>Plant Preparations - metabolism</subject><subject>Plant Preparations - pharmacology</subject><subject>Plants</subject><subject>Review</subject><subject>Saponins - chemistry</subject><subject>Saponins - metabolism</subject><subject>Saponins - pharmacology</subject><subject>Steroids - chemistry</subject><subject>Steroids - metabolism</subject><subject>Steroids - pharmacology</subject><subject>Terpenes - chemistry</subject><subject>Terpenes - metabolism</subject><subject>Terpenes - pharmacology</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJSTZp_kK7l-Rmd0ayJDu3EJoPCOmlPQtZGhMt_thIcmH_fb3s0vSW08DwvPPxMPYNoURA9X1Tbl93eXKvNJQcoCqBl4DiE1thrUUhNMAJWwEILJqK8zN2ntIGAKRU6pSdoUQEVeOKyReb52j7tR1zGHZuaq3LFMPSGSjbdupDpnSzdnOMNOZ1ygufvrDPne0TXR7rBft9_-PX3WPx_PPh6e72uXBVU-VCVYCtV8hrJWpsXSecQCV566QFr7HzUnPvSFND2je-QssrQRq4dg3XUlyw68PcbZzeZkrZDCE56ns70jQno5dvZYP8QxB1UwnB96A-gC5OKUXqzDaGwcadQTB7tWZj_qk1e7UGuFnULsmvxxVzO5B_zx1dLsDVEbDJ2b6LdnQh_cepppawf-r2wNFi7k-gaJILNDryIZLLxk_hw2P-Akcmmws</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Okunade, Adewole L.</creator><creator>Elvin-Lewis, Memory P.F.</creator><creator>Lewis, Walter H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Natural antimycobacterial metabolites: current status</title><author>Okunade, Adewole L. ; Elvin-Lewis, Memory P.F. ; Lewis, Walter H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-6401bd61286381bcf3c31652bc5a0d71fd572dce7e9e7d9d41a243e7027c92753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alkaloids - chemistry</topic><topic>Alkaloids - metabolism</topic><topic>Alkaloids - pharmacology</topic><topic>Antimycobacterial metabolites</topic><topic>Antitubercular Agents - chemistry</topic><topic>Antitubercular Agents - metabolism</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chalcone - chemistry</topic><topic>Chalcone - metabolism</topic><topic>Chalcone - pharmacology</topic><topic>Chromones - chemistry</topic><topic>Chromones - metabolism</topic><topic>Chromones - pharmacology</topic><topic>Coumarins - chemistry</topic><topic>Coumarins - metabolism</topic><topic>Coumarins - pharmacology</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - metabolism</topic><topic>Flavonoids - pharmacology</topic><topic>Fungi</topic><topic>General pharmacology</topic><topic>Marine organisms</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Mycobacterium tuberculosis</topic><topic>Peptides - chemistry</topic><topic>Peptides - metabolism</topic><topic>Peptides - pharmacology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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Mycobacterium tuberculosis, and other mycobacterial species. Included also are traditional medicinal uses of specific plants when utilized to treat tuberculosis and other pulmonary diseases.
The review covers current reports of naturally occurring compounds, and in some cases synthetic analogs, largely from plants, fungi and marine organisms that demonstrate significant activity in the in vitro bioassays against
Mycobacterium tuberculosis (MTB), and other species.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>15110681</pmid><doi>10.1016/j.phytochem.2004.02.013</doi><tpages>16</tpages></addata></record> |
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| subjects | Alkaloids - chemistry Alkaloids - metabolism Alkaloids - pharmacology Antimycobacterial metabolites Antitubercular Agents - chemistry Antitubercular Agents - metabolism Antitubercular Agents - pharmacology Biological and medical sciences Chalcone - chemistry Chalcone - metabolism Chalcone - pharmacology Chromones - chemistry Chromones - metabolism Chromones - pharmacology Coumarins - chemistry Coumarins - metabolism Coumarins - pharmacology Flavonoids - chemistry Flavonoids - metabolism Flavonoids - pharmacology Fungi General pharmacology Marine organisms Medical sciences Microbial Sensitivity Tests Mycobacterium tuberculosis Peptides - chemistry Peptides - metabolism Peptides - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - metabolism Phenols - pharmacology Plant Preparations - chemistry Plant Preparations - metabolism Plant Preparations - pharmacology Plants Review Saponins - chemistry Saponins - metabolism Saponins - pharmacology Steroids - chemistry Steroids - metabolism Steroids - pharmacology Terpenes - chemistry Terpenes - metabolism Terpenes - pharmacology |
| title | Natural antimycobacterial metabolites: current status |
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