On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane

Intramembrane-cleaving proteases are members of a novel type of enzyme that hydrolyse substrate proteins within transmembrane regions. The presently known proteases that catalyse such cleavage reactions are membrane proteins of high hydrophobicity and multiple predicted transmembrane regions. A key...

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Veröffentlicht in:	FEBS Letters 2004-04, Vol.564 (3), p.213-218
Hauptverfasser:	Lemberg, Marius K, Martoglio, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - chemistry Aspartic Acid Endopeptidases - metabolism Cell Membrane - metabolism Hydrolysis Integral membrane protein Lipid bilayer Membrane Proteins - chemistry Membrane Proteins - metabolism Presenilin Protease Protein Conformation Signal peptide peptidase Substrate Specificity
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