Antigen Presentation by CD1d Contributes to the Amplification of Th2 Responses to Schistosoma mansoni Glycoconjugates in Mice

During murine schistosomiasis, there is a gradual switch from a predominant Th1 cytokine response to a Th2-dominated response after egg laying, an event that favors the formation of granuloma around viable eggs. Egg-derived glycoconjugates, including glycolipids, may play a crucial role in this phen...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-07, Vol.169 (2), p.906-912
Hauptverfasser:	Faveeuw, Christelle, Angeli, Veronique, Fontaine, Josette, Maliszewski, Charles, Capron, Andre, Van Kaer, Luc, Moser, Muriel, Capron, Monique, Trottein, Francois
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - genetics Antigens, CD1 - genetics Antigens, CD1 - immunology Antigens, CD1 - metabolism Antigens, CD1 - physiology Antigens, CD1d Antigens, Helminth - immunology Antigens, Helminth - metabolism Cytokines - biosynthesis Dendritic Cells - immunology Dendritic Cells - metabolism Female Glycolipids - immunology Granuloma - genetics Granuloma - immunology Granuloma - parasitology Liver Diseases, Parasitic - genetics Liver Diseases, Parasitic - immunology Liver Diseases, Parasitic - parasitology Mice Mice, Inbred BALB C Mice, Knockout Schistosoma mansoni - growth & development Schistosoma mansoni - immunology Schistosomiasis mansoni - genetics Schistosomiasis mansoni - immunology Schistosomiasis mansoni - parasitology Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - parasitology Up-Regulation - genetics Up-Regulation - immunology
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