Widespread Coronary Inflammation in Unstable Angina
Inflammation within a vulnerable coronary plaque may cause unstable angina by producing erosion or rupture. This study used measurements of neutrophil myeloperoxidase to assess neutrophil activation in blood from the aorta, femoral vein, and great cardiac vein. The data support the concept that in u...
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| Veröffentlicht in: | The New England journal of medicine 2002-07, Vol.347 (1), p.5-12 |
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| container_title | The New England journal of medicine |
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| creator | Buffon, Antonino Biasucci, Luigi M Liuzzo, Giovanna D'Onofrio, Giuseppe Crea, Filippo Maseri, Attilio |
| description | Inflammation within a vulnerable coronary plaque may cause unstable angina by producing erosion or rupture. This study used measurements of neutrophil myeloperoxidase to assess neutrophil activation in blood from the aorta, femoral vein, and great cardiac vein. The data support the concept that in unstable angina there is widespread inflammation in the coronary bed, not just in a single vulnerable plaque.
This study used measurements of neutrophil myeloperoxidase. In unstable angina there appears to be widespread inflammation in the coronary bed.
The hypothesis that inflammation of a vulnerable plaque is responsible for the development of acute coronary syndromes
1
–
5
is stimulating a variety of techniques for the detection and stabilization of vulnerable plaques.
6
–
10
Yet, it is unclear whether the inflammatory process is confined to a single vulnerable plaque or whether it is more widespread in the coronary vasculature.
The possibility of widespread inflammation of the coronary arterial bed is suggested by the recent report of multiple complex coronary plaques in patients with acute myocardial infarction
11
and by previous postmortem findings of multiple fresh thrombi in patients with unstable angina
12
and . . . |
| doi_str_mv | 10.1056/NEJMoa012295 |
| format | Article |
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This study used measurements of neutrophil myeloperoxidase. In unstable angina there appears to be widespread inflammation in the coronary bed.
The hypothesis that inflammation of a vulnerable plaque is responsible for the development of acute coronary syndromes
1
–
5
is stimulating a variety of techniques for the detection and stabilization of vulnerable plaques.
6
–
10
Yet, it is unclear whether the inflammatory process is confined to a single vulnerable plaque or whether it is more widespread in the coronary vasculature.
The possibility of widespread inflammation of the coronary arterial bed is suggested by the recent report of multiple complex coronary plaques in patients with acute myocardial infarction
11
and by previous postmortem findings of multiple fresh thrombi in patients with unstable angina
12
and . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa012295</identifier><identifier>PMID: 12097534</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Aged ; Angina pectoris ; Angina Pectoris - blood ; Angina Pectoris - immunology ; Angina, Unstable - blood ; Angina, Unstable - immunology ; Aorta - immunology ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Catheterization, Central Venous ; Catheterization, Peripheral ; Coronary Circulation - immunology ; Coronary heart disease ; Coronary Stenosis - blood ; Coronary Stenosis - immunology ; Female ; Femoral Vein - immunology ; Health care ; Heart ; Humans ; Inflammation ; Isosorbide Dinitrate - administration & dosage ; Male ; Medical diagnosis ; Medical sciences ; Middle Aged ; Myocardial Ischemia - blood ; Myocardial Ischemia - immunology ; Neutrophil Activation ; Neutrophils - enzymology ; Peroxidase - blood ; Statistics, Nonparametric ; Vasodilator Agents - administration & dosage</subject><ispartof>The New England journal of medicine, 2002-07, Vol.347 (1), p.5-12</ispartof><rights>Copyright © 2002 Massachusetts Medical Society. All rights reserved.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-a5b4ffa622fc8cf53bf34564580aac3583241d97151035ef85b92bd97680b2b23</citedby><cites>FETCH-LOGICAL-c494t-a5b4ffa622fc8cf53bf34564580aac3583241d97151035ef85b92bd97680b2b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa012295$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223936950?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2757,2758,26101,27922,27923,52380,54062,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13761043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12097534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buffon, Antonino</creatorcontrib><creatorcontrib>Biasucci, Luigi M</creatorcontrib><creatorcontrib>Liuzzo, Giovanna</creatorcontrib><creatorcontrib>D'Onofrio, Giuseppe</creatorcontrib><creatorcontrib>Crea, Filippo</creatorcontrib><creatorcontrib>Maseri, Attilio</creatorcontrib><title>Widespread Coronary Inflammation in Unstable Angina</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Inflammation within a vulnerable coronary plaque may cause unstable angina by producing erosion or rupture. This study used measurements of neutrophil myeloperoxidase to assess neutrophil activation in blood from the aorta, femoral vein, and great cardiac vein. The data support the concept that in unstable angina there is widespread inflammation in the coronary bed, not just in a single vulnerable plaque.
This study used measurements of neutrophil myeloperoxidase. In unstable angina there appears to be widespread inflammation in the coronary bed.
The hypothesis that inflammation of a vulnerable plaque is responsible for the development of acute coronary syndromes
1
–
5
is stimulating a variety of techniques for the detection and stabilization of vulnerable plaques.
6
–
10
Yet, it is unclear whether the inflammatory process is confined to a single vulnerable plaque or whether it is more widespread in the coronary vasculature.
The possibility of widespread inflammation of the coronary arterial bed is suggested by the recent report of multiple complex coronary plaques in patients with acute myocardial infarction
11
and by previous postmortem findings of multiple fresh thrombi in patients with unstable angina
12
and . . .</description><subject>Aged</subject><subject>Angina pectoris</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - immunology</subject><subject>Angina, Unstable - blood</subject><subject>Angina, Unstable - immunology</subject><subject>Aorta - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Catheterization, Central Venous</subject><subject>Catheterization, Peripheral</subject><subject>Coronary Circulation - immunology</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - blood</subject><subject>Coronary Stenosis - immunology</subject><subject>Female</subject><subject>Femoral Vein - immunology</subject><subject>Health care</subject><subject>Heart</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Isosorbide Dinitrate - administration & dosage</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - immunology</subject><subject>Neutrophil Activation</subject><subject>Neutrophils - enzymology</subject><subject>Peroxidase - blood</subject><subject>Statistics, Nonparametric</subject><subject>Vasodilator Agents - administration & dosage</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0E1LwzAYB_AgipvTm2cpop6s5rVNjmNMnUy9ODyGpEuko0ln0h789kZWUMRcHgg_npc_AKcI3iDIitvn-eNTqyDCWLA9MEaMkJxSWOyDMYSY57QUZASOYtzA9BAVh2CEMBQlI3QMyFu9NnEbjFpnsza0XoXPbOFto5xTXd36rPbZysdO6cZkU_9ee3UMDqxqojkZ6gSs7uavs4d8-XK_mE2XeUUF7XLFNLVWFRjbileWEW0JZQVlHCpVEcYJpmgtSsQQJMxYzrTAOn0UHGqsMZmAq13fbWg_ehM76epYmaZR3rR9lCXiJeHpvAk4_wM3bR982k1iTAQpBIMJXe9QFdoYg7FyG2qXzpUIyu8k5e8kEz8bevbamfUPHqJL4HIAKlaqsUH5qo4_jpQFgpQkd7FzzkXpzcb9P-8L9FCEFA</recordid><startdate>20020704</startdate><enddate>20020704</enddate><creator>Buffon, Antonino</creator><creator>Biasucci, Luigi M</creator><creator>Liuzzo, Giovanna</creator><creator>D'Onofrio, Giuseppe</creator><creator>Crea, Filippo</creator><creator>Maseri, Attilio</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020704</creationdate><title>Widespread Coronary Inflammation in Unstable Angina</title><author>Buffon, Antonino ; Biasucci, Luigi M ; Liuzzo, Giovanna ; D'Onofrio, Giuseppe ; Crea, Filippo ; Maseri, Attilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-a5b4ffa622fc8cf53bf34564580aac3583241d97151035ef85b92bd97680b2b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Angina pectoris</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - immunology</topic><topic>Angina, Unstable - blood</topic><topic>Angina, Unstable - immunology</topic><topic>Aorta - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Catheterization, Central Venous</topic><topic>Catheterization, Peripheral</topic><topic>Coronary Circulation - immunology</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - blood</topic><topic>Coronary Stenosis - immunology</topic><topic>Female</topic><topic>Femoral Vein - immunology</topic><topic>Health care</topic><topic>Heart</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Isosorbide Dinitrate - administration & dosage</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - blood</topic><topic>Myocardial Ischemia - immunology</topic><topic>Neutrophil Activation</topic><topic>Neutrophils - enzymology</topic><topic>Peroxidase - blood</topic><topic>Statistics, Nonparametric</topic><topic>Vasodilator Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buffon, Antonino</creatorcontrib><creatorcontrib>Biasucci, Luigi M</creatorcontrib><creatorcontrib>Liuzzo, Giovanna</creatorcontrib><creatorcontrib>D'Onofrio, Giuseppe</creatorcontrib><creatorcontrib>Crea, Filippo</creatorcontrib><creatorcontrib>Maseri, Attilio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buffon, Antonino</au><au>Biasucci, Luigi M</au><au>Liuzzo, Giovanna</au><au>D'Onofrio, Giuseppe</au><au>Crea, Filippo</au><au>Maseri, Attilio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Widespread Coronary Inflammation in Unstable Angina</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2002-07-04</date><risdate>2002</risdate><volume>347</volume><issue>1</issue><spage>5</spage><epage>12</epage><pages>5-12</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Inflammation within a vulnerable coronary plaque may cause unstable angina by producing erosion or rupture. This study used measurements of neutrophil myeloperoxidase to assess neutrophil activation in blood from the aorta, femoral vein, and great cardiac vein. The data support the concept that in unstable angina there is widespread inflammation in the coronary bed, not just in a single vulnerable plaque.
This study used measurements of neutrophil myeloperoxidase. In unstable angina there appears to be widespread inflammation in the coronary bed.
The hypothesis that inflammation of a vulnerable plaque is responsible for the development of acute coronary syndromes
1
–
5
is stimulating a variety of techniques for the detection and stabilization of vulnerable plaques.
6
–
10
Yet, it is unclear whether the inflammatory process is confined to a single vulnerable plaque or whether it is more widespread in the coronary vasculature.
The possibility of widespread inflammation of the coronary arterial bed is suggested by the recent report of multiple complex coronary plaques in patients with acute myocardial infarction
11
and by previous postmortem findings of multiple fresh thrombi in patients with unstable angina
12
and . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>12097534</pmid><doi>10.1056/NEJMoa012295</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2002-07, Vol.347 (1), p.5-12 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aged Angina pectoris Angina Pectoris - blood Angina Pectoris - immunology Angina, Unstable - blood Angina, Unstable - immunology Aorta - immunology Biological and medical sciences Biomarkers - blood C-Reactive Protein - metabolism Cardiology. Vascular system Catheterization, Central Venous Catheterization, Peripheral Coronary Circulation - immunology Coronary heart disease Coronary Stenosis - blood Coronary Stenosis - immunology Female Femoral Vein - immunology Health care Heart Humans Inflammation Isosorbide Dinitrate - administration & dosage Male Medical diagnosis Medical sciences Middle Aged Myocardial Ischemia - blood Myocardial Ischemia - immunology Neutrophil Activation Neutrophils - enzymology Peroxidase - blood Statistics, Nonparametric Vasodilator Agents - administration & dosage |
| title | Widespread Coronary Inflammation in Unstable Angina |
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