Risk factors for incident nuclear opacities
To evaluate risk factors for the 4-year incidence of nuclear opacities. Population-based cohort study (85% participation at 4-year follow-up). Two thousand six hundred nine black participants of the Barbados Eye Studies, without any nuclear opacities at baseline. Participants completed a standardize...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2002-07, Vol.109 (7), p.1303-1308 |
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| creator | Leske, M.Cristina Wu, Suh-Yuh Nemesure, Barbara Hennis, Anselm |
| description | To evaluate risk factors for the 4-year incidence of nuclear opacities.
Population-based cohort study (85% participation at 4-year follow-up).
Two thousand six hundred nine black participants of the Barbados Eye Studies, without any nuclear opacities at baseline.
Participants completed a standardized protocol at baseline and follow-up, including ophthalmic and other measurements, an interview, slit-lamp lens grading, fundus photography, and an ophthalmologic examination. Factors associated with the incidence of nuclear opacities (Lens Opacities Classification System II N ≥ 2) were evaluated by logistic regression.
Relative risks (RR) with 95% confidence intervals (95% CI).
The 4-year incidence of nuclear opacities was 9.2% (241 of 2609) and increased greatly with age. Women were at significantly greater risk (RR = 1.8), as were persons with darker iris color (RR = 4.9), myopia (RR = 2.8), history of diabetes (RR = 1.6), leaner body mass (RR = 0.95 for each unit increase in body mass index [kg/m
2]), and intraocular pressure (IOP)-lowering treatment (RR = 2.7), mainly with topical β-blockers. Treated participants had a threefold RR of nuclear opacities (RR = 3.2; 95% CI, 1.6, 6.5) compared with those untreated and with IOP ≤21 mmHg. Among participants with IOP >21 mmHg, those receiving treatment (n = 33) had a fivefold RR (RR = 5.0; 95% CI, 1.7, 15.1) versus those who were untreated. The RR was similar for treated persons with and without open-angle glaucoma (RR = 3.1; 95% CI, 1.3, 7.4 and RR = 2.8; 95% CI, 0.9, 8.6 respectively) but was lower in persons with newly detected (and thus untreated) glaucoma at baseline (RR = 1.2; 95% CI, 0.6, 2.6) compared with those without open-angle glaucoma or treatment.
The 4-year risk of nuclear opacities increased with age, female gender, darker iris color, myopia, diabetes, and leaner body mass, indicating similarities with other populations. The use of topical IOP-lowering medications tripled the RR of nuclear opacities in this study, an association that requires verification from clinical trials. |
| doi_str_mv | 10.1016/S0161-6420(02)01094-1 |
| format | Article |
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Population-based cohort study (85% participation at 4-year follow-up).
Two thousand six hundred nine black participants of the Barbados Eye Studies, without any nuclear opacities at baseline.
Participants completed a standardized protocol at baseline and follow-up, including ophthalmic and other measurements, an interview, slit-lamp lens grading, fundus photography, and an ophthalmologic examination. Factors associated with the incidence of nuclear opacities (Lens Opacities Classification System II N ≥ 2) were evaluated by logistic regression.
Relative risks (RR) with 95% confidence intervals (95% CI).
The 4-year incidence of nuclear opacities was 9.2% (241 of 2609) and increased greatly with age. Women were at significantly greater risk (RR = 1.8), as were persons with darker iris color (RR = 4.9), myopia (RR = 2.8), history of diabetes (RR = 1.6), leaner body mass (RR = 0.95 for each unit increase in body mass index [kg/m
2]), and intraocular pressure (IOP)-lowering treatment (RR = 2.7), mainly with topical β-blockers. Treated participants had a threefold RR of nuclear opacities (RR = 3.2; 95% CI, 1.6, 6.5) compared with those untreated and with IOP ≤21 mmHg. Among participants with IOP >21 mmHg, those receiving treatment (n = 33) had a fivefold RR (RR = 5.0; 95% CI, 1.7, 15.1) versus those who were untreated. The RR was similar for treated persons with and without open-angle glaucoma (RR = 3.1; 95% CI, 1.3, 7.4 and RR = 2.8; 95% CI, 0.9, 8.6 respectively) but was lower in persons with newly detected (and thus untreated) glaucoma at baseline (RR = 1.2; 95% CI, 0.6, 2.6) compared with those without open-angle glaucoma or treatment.
The 4-year risk of nuclear opacities increased with age, female gender, darker iris color, myopia, diabetes, and leaner body mass, indicating similarities with other populations. The use of topical IOP-lowering medications tripled the RR of nuclear opacities in this study, an association that requires verification from clinical trials.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(02)01094-1</identifier><identifier>PMID: 12093655</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; African Continental Ancestry Group ; Aged ; Aged, 80 and over ; Aging - pathology ; Barbados - epidemiology ; Biological and medical sciences ; Cataract - ethnology ; Cataract - pathology ; Cohort Studies ; Confidence Intervals ; Female ; Humans ; Incidence ; Lens diseases ; Lens Nucleus, Crystalline - pathology ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Prevalence ; Risk Factors ; Sex Factors</subject><ispartof>Ophthalmology (Rochester, Minn.), 2002-07, Vol.109 (7), p.1303-1308</ispartof><rights>2002 American Academy of Ophthalmology, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-479dcd07772a3e9a486ecaadc7162fdf07f52b63fa9e37510406a78fae9c03a3</citedby><cites>FETCH-LOGICAL-c538t-479dcd07772a3e9a486ecaadc7162fdf07f52b63fa9e37510406a78fae9c03a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161642002010941$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13761185$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12093655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leske, M.Cristina</creatorcontrib><creatorcontrib>Wu, Suh-Yuh</creatorcontrib><creatorcontrib>Nemesure, Barbara</creatorcontrib><creatorcontrib>Hennis, Anselm</creatorcontrib><creatorcontrib>Barbados Eye Studies Group</creatorcontrib><title>Risk factors for incident nuclear opacities</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To evaluate risk factors for the 4-year incidence of nuclear opacities.
Population-based cohort study (85% participation at 4-year follow-up).
Two thousand six hundred nine black participants of the Barbados Eye Studies, without any nuclear opacities at baseline.
Participants completed a standardized protocol at baseline and follow-up, including ophthalmic and other measurements, an interview, slit-lamp lens grading, fundus photography, and an ophthalmologic examination. Factors associated with the incidence of nuclear opacities (Lens Opacities Classification System II N ≥ 2) were evaluated by logistic regression.
Relative risks (RR) with 95% confidence intervals (95% CI).
The 4-year incidence of nuclear opacities was 9.2% (241 of 2609) and increased greatly with age. Women were at significantly greater risk (RR = 1.8), as were persons with darker iris color (RR = 4.9), myopia (RR = 2.8), history of diabetes (RR = 1.6), leaner body mass (RR = 0.95 for each unit increase in body mass index [kg/m
2]), and intraocular pressure (IOP)-lowering treatment (RR = 2.7), mainly with topical β-blockers. Treated participants had a threefold RR of nuclear opacities (RR = 3.2; 95% CI, 1.6, 6.5) compared with those untreated and with IOP ≤21 mmHg. Among participants with IOP >21 mmHg, those receiving treatment (n = 33) had a fivefold RR (RR = 5.0; 95% CI, 1.7, 15.1) versus those who were untreated. The RR was similar for treated persons with and without open-angle glaucoma (RR = 3.1; 95% CI, 1.3, 7.4 and RR = 2.8; 95% CI, 0.9, 8.6 respectively) but was lower in persons with newly detected (and thus untreated) glaucoma at baseline (RR = 1.2; 95% CI, 0.6, 2.6) compared with those without open-angle glaucoma or treatment.
The 4-year risk of nuclear opacities increased with age, female gender, darker iris color, myopia, diabetes, and leaner body mass, indicating similarities with other populations. The use of topical IOP-lowering medications tripled the RR of nuclear opacities in this study, an association that requires verification from clinical trials.</description><subject>Adult</subject><subject>African Continental Ancestry Group</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Barbados - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cataract - ethnology</subject><subject>Cataract - pathology</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lens diseases</subject><subject>Lens Nucleus, Crystalline - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-BCUXRZHobDbZTU4ixS8oCNr7Mt3Mwmqa1N1E8N-btsEevcxcnnfe4WHslMMNBy5v3_vBY5kmcAnJFXAo0pjvsTHP0iJOFRf7bPyHjNhRCB8AIKVID9mIJ1AImWVjdv3mwmdk0bSND5FtfORq40qq26juTEXoo2aFxrWOwjE7sFgFOhn2hM0fH-bT53j2-vQyvZ_FJhN525cXpSlBKZWgoALTXJJBLI3iMrGlBWWzZCGFxYKEyjikIFHlFqkwIFBM2MX27Mo3Xx2FVi9dMFRVWFPTBa14roRMsh7MtqDxTQierF55t0T_oznotSS9kaTXBjQkeiNJ8z53NhR0iyWVu9RgpQfOBwCDwcp67J2EHSeU5Dxfc3dbjnob3468DsZRbah0nkyry8b988ovXXGCTQ</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Leske, M.Cristina</creator><creator>Wu, Suh-Yuh</creator><creator>Nemesure, Barbara</creator><creator>Hennis, Anselm</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Risk factors for incident nuclear opacities</title><author>Leske, M.Cristina ; Wu, Suh-Yuh ; Nemesure, Barbara ; Hennis, Anselm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-479dcd07772a3e9a486ecaadc7162fdf07f52b63fa9e37510406a78fae9c03a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>African Continental Ancestry Group</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>Barbados - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cataract - ethnology</topic><topic>Cataract - pathology</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lens diseases</topic><topic>Lens Nucleus, Crystalline - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leske, M.Cristina</creatorcontrib><creatorcontrib>Wu, Suh-Yuh</creatorcontrib><creatorcontrib>Nemesure, Barbara</creatorcontrib><creatorcontrib>Hennis, Anselm</creatorcontrib><creatorcontrib>Barbados Eye Studies Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leske, M.Cristina</au><au>Wu, Suh-Yuh</au><au>Nemesure, Barbara</au><au>Hennis, Anselm</au><aucorp>Barbados Eye Studies Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for incident nuclear opacities</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>109</volume><issue>7</issue><spage>1303</spage><epage>1308</epage><pages>1303-1308</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To evaluate risk factors for the 4-year incidence of nuclear opacities.
Population-based cohort study (85% participation at 4-year follow-up).
Two thousand six hundred nine black participants of the Barbados Eye Studies, without any nuclear opacities at baseline.
Participants completed a standardized protocol at baseline and follow-up, including ophthalmic and other measurements, an interview, slit-lamp lens grading, fundus photography, and an ophthalmologic examination. Factors associated with the incidence of nuclear opacities (Lens Opacities Classification System II N ≥ 2) were evaluated by logistic regression.
Relative risks (RR) with 95% confidence intervals (95% CI).
The 4-year incidence of nuclear opacities was 9.2% (241 of 2609) and increased greatly with age. Women were at significantly greater risk (RR = 1.8), as were persons with darker iris color (RR = 4.9), myopia (RR = 2.8), history of diabetes (RR = 1.6), leaner body mass (RR = 0.95 for each unit increase in body mass index [kg/m
2]), and intraocular pressure (IOP)-lowering treatment (RR = 2.7), mainly with topical β-blockers. Treated participants had a threefold RR of nuclear opacities (RR = 3.2; 95% CI, 1.6, 6.5) compared with those untreated and with IOP ≤21 mmHg. Among participants with IOP >21 mmHg, those receiving treatment (n = 33) had a fivefold RR (RR = 5.0; 95% CI, 1.7, 15.1) versus those who were untreated. The RR was similar for treated persons with and without open-angle glaucoma (RR = 3.1; 95% CI, 1.3, 7.4 and RR = 2.8; 95% CI, 0.9, 8.6 respectively) but was lower in persons with newly detected (and thus untreated) glaucoma at baseline (RR = 1.2; 95% CI, 0.6, 2.6) compared with those without open-angle glaucoma or treatment.
The 4-year risk of nuclear opacities increased with age, female gender, darker iris color, myopia, diabetes, and leaner body mass, indicating similarities with other populations. The use of topical IOP-lowering medications tripled the RR of nuclear opacities in this study, an association that requires verification from clinical trials.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12093655</pmid><doi>10.1016/S0161-6420(02)01094-1</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0161-6420 |
| ispartof | Ophthalmology (Rochester, Minn.), 2002-07, Vol.109 (7), p.1303-1308 |
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| subjects | Adult African Continental Ancestry Group Aged Aged, 80 and over Aging - pathology Barbados - epidemiology Biological and medical sciences Cataract - ethnology Cataract - pathology Cohort Studies Confidence Intervals Female Humans Incidence Lens diseases Lens Nucleus, Crystalline - pathology Male Medical sciences Middle Aged Ophthalmology Prevalence Risk Factors Sex Factors |
| title | Risk factors for incident nuclear opacities |
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