Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: Association studies in German and Slavic population
Serotonergic dysfunction is believed to be involved in the susceptibility to suicide due to functional alternations in the serotonin‐related genes. Serotonin 1B (5HT‐1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity...
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2004-05, Vol.127B (1), p.48-50 |
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| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| container_volume | 127B |
| creator | Stefulj, Jasminka Büttner, Andreas Skavic, Josip Zill, Peter Balija, Melita Eisenmenger, Wolfgang Bondy, Brigitta Jernej, Branimir |
| description | Serotonergic dysfunction is believed to be involved in the susceptibility to suicide due to functional alternations in the serotonin‐related genes. Serotonin 1B (5HT‐1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity in humans. In this study we have investigated the association of G861C polymorphism of the 5HT‐1B receptor gene with suicide commitment. Study was based on two independent samples, one of German (245 suicide victims vs. 248 controls) and the other of Slavic/Croatian (118 suicide victims vs. 192 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated either in German or Croatian sample. There were no differences in allele frequencies between German and Croatian population, and the combined sample, having high statistical power, also did not demonstrate significant differences between victims and controls. Results provide evidence that the investigated 5HT‐1B receptor gene variants are not implicated in the susceptibility to suicide. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.20174 |
| format | Article |
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Serotonin 1B (5HT‐1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity in humans. In this study we have investigated the association of G861C polymorphism of the 5HT‐1B receptor gene with suicide commitment. Study was based on two independent samples, one of German (245 suicide victims vs. 248 controls) and the other of Slavic/Croatian (118 suicide victims vs. 192 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated either in German or Croatian sample. There were no differences in allele frequencies between German and Croatian population, and the combined sample, having high statistical power, also did not demonstrate significant differences between victims and controls. Results provide evidence that the investigated 5HT‐1B receptor gene variants are not implicated in the susceptibility to suicide. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.20174</identifier><identifier>PMID: 15108179</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>5HT-1B receptor gene ; Adult ; Aged ; Alleles ; Croatia ; Deoxyribonucleases, Type II Site-Specific - metabolism ; DNA - genetics ; DNA - metabolism ; Electrophoresis, Agar Gel ; ethnicity ; Female ; Gene Frequency ; Genetic Predisposition to Disease - genetics ; Genotype ; Germany ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Receptor, Serotonin, 5-HT1B - genetics ; suicidal behavior ; Suicide - ethnology ; Suicide - psychology</subject><ispartof>American journal of medical genetics. 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Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Serotonergic dysfunction is believed to be involved in the susceptibility to suicide due to functional alternations in the serotonin‐related genes. Serotonin 1B (5HT‐1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity in humans. In this study we have investigated the association of G861C polymorphism of the 5HT‐1B receptor gene with suicide commitment. Study was based on two independent samples, one of German (245 suicide victims vs. 248 controls) and the other of Slavic/Croatian (118 suicide victims vs. 192 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated either in German or Croatian sample. There were no differences in allele frequencies between German and Croatian population, and the combined sample, having high statistical power, also did not demonstrate significant differences between victims and controls. Results provide evidence that the investigated 5HT‐1B receptor gene variants are not implicated in the susceptibility to suicide. © 2004 Wiley‐Liss, Inc.</description><subject>5HT-1B receptor gene</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Croatia</subject><subject>Deoxyribonucleases, Type II Site-Specific - metabolism</subject><subject>DNA - genetics</subject><subject>DNA - metabolism</subject><subject>Electrophoresis, Agar Gel</subject><subject>ethnicity</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Germany</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptor, Serotonin, 5-HT1B - genetics</subject><subject>suicidal behavior</subject><subject>Suicide - ethnology</subject><subject>Suicide - psychology</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9v0zAUgC0EYj_gxhn5hDaJFL_Yrh1ubQXppq0gNgQ3y3Uc8EjizE6Ain9-7lrGjdOz_L73HT6EXgCZACH5G33TfpusJzkBwR6hQ-A8z5jkXx8_vBkcoKMYbwihhAvxFB0AByJBFIfoz5UNfvCd6zDM8QlfXmcwP8XBGtsPPuDeN5vWh_67iy0-KeUUFqc4wXF0xlUW_3RmcG18i2cxeuP04HxaDmPlbNxypQ2t7rDuKnzV6EQnYz8299wz9KTWTbTP9_MYfX7_7nqxzC4-lGeL2UVmGCEsoyANtYTT3BjDCpjKtZGS6KrmadJpoVkOVcFN-pGsqCtWEA6VqettEgB6jF7tvH3wt6ONg2pdNLZpdGf9GJUAKaAAkcDXO9AEH2OwteqDa3XYKCBqG1ttY6u1uo-d8Jd777hubfUP3tdNAN0Bv1xjN_-Vqdn5ZflXm-2uXBzs74crHX6oqaCCqy-rUn1afVzNV5fnaknvAKatmb8</recordid><startdate>20040515</startdate><enddate>20040515</enddate><creator>Stefulj, Jasminka</creator><creator>Büttner, Andreas</creator><creator>Skavic, Josip</creator><creator>Zill, Peter</creator><creator>Balija, Melita</creator><creator>Eisenmenger, Wolfgang</creator><creator>Bondy, Brigitta</creator><creator>Jernej, Branimir</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040515</creationdate><title>Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: Association studies in German and Slavic population</title><author>Stefulj, Jasminka ; Büttner, Andreas ; Skavic, Josip ; Zill, Peter ; Balija, Melita ; Eisenmenger, Wolfgang ; Bondy, Brigitta ; Jernej, Branimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4004-318c3e0532ccc49168bc880adf5c88369a421d95cadf849fd49051dcff0174113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>5HT-1B receptor gene</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Croatia</topic><topic>Deoxyribonucleases, Type II Site-Specific - metabolism</topic><topic>DNA - genetics</topic><topic>DNA - metabolism</topic><topic>Electrophoresis, Agar Gel</topic><topic>ethnicity</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Germany</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptor, Serotonin, 5-HT1B - genetics</topic><topic>suicidal behavior</topic><topic>Suicide - ethnology</topic><topic>Suicide - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stefulj, Jasminka</creatorcontrib><creatorcontrib>Büttner, Andreas</creatorcontrib><creatorcontrib>Skavic, Josip</creatorcontrib><creatorcontrib>Zill, Peter</creatorcontrib><creatorcontrib>Balija, Melita</creatorcontrib><creatorcontrib>Eisenmenger, Wolfgang</creatorcontrib><creatorcontrib>Bondy, Brigitta</creatorcontrib><creatorcontrib>Jernej, Branimir</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics. 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| ispartof | American journal of medical genetics. Part B, Neuropsychiatric genetics, 2004-05, Vol.127B (1), p.48-50 |
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| subjects | 5HT-1B receptor gene Adult Aged Alleles Croatia Deoxyribonucleases, Type II Site-Specific - metabolism DNA - genetics DNA - metabolism Electrophoresis, Agar Gel ethnicity Female Gene Frequency Genetic Predisposition to Disease - genetics Genotype Germany Humans Male Middle Aged Polymorphism, Single Nucleotide Receptor, Serotonin, 5-HT1B - genetics suicidal behavior Suicide - ethnology Suicide - psychology |
| title | Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: Association studies in German and Slavic population |
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