Structural Basis for Transcription Regulation by Alarmone ppGpp

Guanosine-tetraphosphate (ppGpp) is a major regulator of stringent control, an adaptive response of bacteria to amino acid starvation. The 2.7 Å resolution structure of the Thermus thermophilus RNA polymerase (RNAP) holoenzyme in complex with ppGpp reveals that ppGpp binds to the same site near the...

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Veröffentlicht in:	Cell 2004-04, Vol.117 (3), p.299-310
Hauptverfasser:	Artsimovitch, Irina, Patlan, Vsevolod, Sekine, Shun-ichi, Vassylyeva, Marina N, Hosaka, Takeshi, Ochi, Kozo, Yokoyama, Shigeyuki, Vassylyev, Dmitry G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Crystallography, X-Ray Gene Expression Regulation, Bacterial Hydrogen Bonding Magnesium - metabolism Models, Molecular Promoter Regions, Genetic Protein Structure, Secondary Protein Subunits - chemistry Pyrophosphatases - chemistry Pyrophosphatases - genetics Pyrophosphatases - metabolism Reproducibility of Results Static Electricity Thermus thermophilus Thermus thermophilus - enzymology Thermus thermophilus - genetics Transcription, Genetic Water - chemistry
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