Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects
An ovine model was used to investigate the in vivo properties of impacted tricalcium phosphate–hydroxyapatite (TCP–HA) aggregates, varying in chemical composition (ratio of TCP to HA) and particle size distribution (8 versus 3 particle size ranges). All pellets were impacted to a standard compactive...
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| Veröffentlicht in: | Biomaterials 2002-08, Vol.23 (16), p.3309-3317 |
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| creator | Pratt, J.N.J. Griffon, D.J. Dunlop, D.G. Smith, N. Howie, C.R. |
| description | An ovine model was used to investigate the in vivo properties of impacted tricalcium phosphate–hydroxyapatite (TCP–HA) aggregates, varying in chemical composition (ratio of TCP to HA) and particle size distribution (8 versus 3 particle size ranges). All pellets were impacted to a standard compactive effort.
Eight sheep underwent implantation of pellets in 4 metaphyseal defects in both rear limbs. Treatment groups consisted of: (1) allograft (clinical control), (2) 50/50 allograft/80% HA/20% TCP in 8 particle size ranges, (3) 50/50 allograft/80% TCP/20% HA in 8 sizes and (4) 50/50 allograft/80% HA/20% TCP in only 3 sizes of particles. Healing of defects was evaluated at 14 weeks with computed tomography, histology and histomorphometry. The computer tomography (CT) density measured in all defects containing synthetic agents was higher than in defects filled with allograft alone (p |
| doi_str_mv | 10.1016/S0142-9612(02)00018-2 |
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Eight sheep underwent implantation of pellets in 4 metaphyseal defects in both rear limbs. Treatment groups consisted of: (1) allograft (clinical control), (2) 50/50 allograft/80% HA/20% TCP in 8 particle size ranges, (3) 50/50 allograft/80% TCP/20% HA in 8 sizes and (4) 50/50 allograft/80% HA/20% TCP in only 3 sizes of particles. Healing of defects was evaluated at 14 weeks with computed tomography, histology and histomorphometry. The computer tomography (CT) density measured in all defects containing synthetic agents was higher than in defects filled with allograft alone (p<0.01). Defects containing 8 sizes of 80% HA/20% TCP granules (group 2) achieved lower histological scores and contained less bone than the clinical control (p<0.05), whereas groups 3 and 4 did not differ from the control. Although all synthetic agents were osteoconductive, our results suggest that increasing the ratio of TCP over HA and limiting the number of particle size ranges to 3 instead of 8 improve the performance of impacted aggregates as graft expanders. Evaluation under loading conditions of morsellised allograft expanded with 80% TCP/20% HA (BoneSave®) in 3 particle size ranges is warranted.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(02)00018-2</identifier><identifier>PMID: 12099273</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Bone Diseases - surgery ; Bone Substitutes - therapeutic use ; Calcium Phosphates - therapeutic use ; Hindlimb ; Hydroxyapatite ; Hydroxyapatites - therapeutic use ; Impaction grafting ; Revision hip arthroplasty ; Sheep ; Tomography, X-Ray Computed ; Transplantation, Homologous - methods ; Tricalcium phosphate</subject><ispartof>Biomaterials, 2002-08, Vol.23 (16), p.3309-3317</ispartof><rights>2002 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-905dce91b393b206218e42f29fdf16438fb207cc6acedb2f27081ab9ceaaf2ac3</citedby><cites>FETCH-LOGICAL-c454t-905dce91b393b206218e42f29fdf16438fb207cc6acedb2f27081ab9ceaaf2ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961202000182$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12099273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pratt, J.N.J.</creatorcontrib><creatorcontrib>Griffon, D.J.</creatorcontrib><creatorcontrib>Dunlop, D.G.</creatorcontrib><creatorcontrib>Smith, N.</creatorcontrib><creatorcontrib>Howie, C.R.</creatorcontrib><title>Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>An ovine model was used to investigate the in vivo properties of impacted tricalcium phosphate–hydroxyapatite (TCP–HA) aggregates, varying in chemical composition (ratio of TCP to HA) and particle size distribution (8 versus 3 particle size ranges). All pellets were impacted to a standard compactive effort.
Eight sheep underwent implantation of pellets in 4 metaphyseal defects in both rear limbs. Treatment groups consisted of: (1) allograft (clinical control), (2) 50/50 allograft/80% HA/20% TCP in 8 particle size ranges, (3) 50/50 allograft/80% TCP/20% HA in 8 sizes and (4) 50/50 allograft/80% HA/20% TCP in only 3 sizes of particles. Healing of defects was evaluated at 14 weeks with computed tomography, histology and histomorphometry. The computer tomography (CT) density measured in all defects containing synthetic agents was higher than in defects filled with allograft alone (p<0.01). Defects containing 8 sizes of 80% HA/20% TCP granules (group 2) achieved lower histological scores and contained less bone than the clinical control (p<0.05), whereas groups 3 and 4 did not differ from the control. Although all synthetic agents were osteoconductive, our results suggest that increasing the ratio of TCP over HA and limiting the number of particle size ranges to 3 instead of 8 improve the performance of impacted aggregates as graft expanders. Evaluation under loading conditions of morsellised allograft expanded with 80% TCP/20% HA (BoneSave®) in 3 particle size ranges is warranted.</description><subject>Animals</subject><subject>Bone Diseases - surgery</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Calcium Phosphates - therapeutic use</subject><subject>Hindlimb</subject><subject>Hydroxyapatite</subject><subject>Hydroxyapatites - therapeutic use</subject><subject>Impaction grafting</subject><subject>Revision hip arthroplasty</subject><subject>Sheep</subject><subject>Tomography, X-Ray Computed</subject><subject>Transplantation, Homologous - methods</subject><subject>Tricalcium phosphate</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks2KFDEQx4Mo7rj6CEpOoofWJP2V9rLI4sfCggf1HKqTynaku9MmmdW5-QDefEOfxPTMoMcRAoGqX-qfqvoT8pizF5zx5uVHxitRdA0Xz5h4zhjjshB3yIbLVhZ1x-q7ZPMXOSMPYvySmYpV4j4544J1nWjLDfl5NS2gk_MzvQlgk5tv6DeXBjr5EHEcXURDYRz9PkthNjQFp2HUbjvRZfBxGSDh7x-_hp0J_vsOFkgu4SvqZu3D4gPsi6813Uz9rZuRTphgGXYRYaS9zwGDFnWKD8k9C2PER8f7nHx---bT5fvi-sO7q8vX14Wu6ioVuTmjseN92ZW9YI3gEithRWeN5U1VSpujrdYNaDR9TrRMcug7jQBWgC7PydND3SX4r1uMSU0u6twtzOi3UbV5iLzi_CQoWiHqMn_jf8CSteIkyGUtZVOWGawPoA4-xoBWLcFNEHaKM7U6QO0doNb1KpbP6gC1Cjw5Cmz7Cc2_V8eVZ-DiAGCe8K3DoKJ2OOdRuZCXoIx3JyT-AKWuxZY</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Pratt, J.N.J.</creator><creator>Griffon, D.J.</creator><creator>Dunlop, D.G.</creator><creator>Smith, N.</creator><creator>Howie, C.R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>F28</scope><scope>JG9</scope><scope>7QQ</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects</title><author>Pratt, J.N.J. ; Griffon, D.J. ; Dunlop, D.G. ; Smith, N. ; Howie, C.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-905dce91b393b206218e42f29fdf16438fb207cc6acedb2f27081ab9ceaaf2ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Bone Diseases - surgery</topic><topic>Bone Substitutes - therapeutic use</topic><topic>Calcium Phosphates - therapeutic use</topic><topic>Hindlimb</topic><topic>Hydroxyapatite</topic><topic>Hydroxyapatites - therapeutic use</topic><topic>Impaction grafting</topic><topic>Revision hip arthroplasty</topic><topic>Sheep</topic><topic>Tomography, X-Ray Computed</topic><topic>Transplantation, Homologous - methods</topic><topic>Tricalcium phosphate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pratt, J.N.J.</creatorcontrib><creatorcontrib>Griffon, D.J.</creatorcontrib><creatorcontrib>Dunlop, D.G.</creatorcontrib><creatorcontrib>Smith, N.</creatorcontrib><creatorcontrib>Howie, C.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Ceramic Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pratt, J.N.J.</au><au>Griffon, D.J.</au><au>Dunlop, D.G.</au><au>Smith, N.</au><au>Howie, C.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>23</volume><issue>16</issue><spage>3309</spage><epage>3317</epage><pages>3309-3317</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>An ovine model was used to investigate the in vivo properties of impacted tricalcium phosphate–hydroxyapatite (TCP–HA) aggregates, varying in chemical composition (ratio of TCP to HA) and particle size distribution (8 versus 3 particle size ranges). All pellets were impacted to a standard compactive effort.
Eight sheep underwent implantation of pellets in 4 metaphyseal defects in both rear limbs. Treatment groups consisted of: (1) allograft (clinical control), (2) 50/50 allograft/80% HA/20% TCP in 8 particle size ranges, (3) 50/50 allograft/80% TCP/20% HA in 8 sizes and (4) 50/50 allograft/80% HA/20% TCP in only 3 sizes of particles. Healing of defects was evaluated at 14 weeks with computed tomography, histology and histomorphometry. The computer tomography (CT) density measured in all defects containing synthetic agents was higher than in defects filled with allograft alone (p<0.01). Defects containing 8 sizes of 80% HA/20% TCP granules (group 2) achieved lower histological scores and contained less bone than the clinical control (p<0.05), whereas groups 3 and 4 did not differ from the control. Although all synthetic agents were osteoconductive, our results suggest that increasing the ratio of TCP over HA and limiting the number of particle size ranges to 3 instead of 8 improve the performance of impacted aggregates as graft expanders. Evaluation under loading conditions of morsellised allograft expanded with 80% TCP/20% HA (BoneSave®) in 3 particle size ranges is warranted.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>12099273</pmid><doi>10.1016/S0142-9612(02)00018-2</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Bone Diseases - surgery Bone Substitutes - therapeutic use Calcium Phosphates - therapeutic use Hindlimb Hydroxyapatite Hydroxyapatites - therapeutic use Impaction grafting Revision hip arthroplasty Sheep Tomography, X-Ray Computed Transplantation, Homologous - methods Tricalcium phosphate |
| title | Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects |
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