Undifferentiated sarcoma of the parotid gland with osseous metaplasia
Malignant spindle cell tumors of the parotid gland are a diagnostic challenge. We present an unusual case of such a tumor that occurred in the right parotid gland of a 53-year-old man. The clinical and histologic assessments were consistent with a primary sarcoma of the parotid gland. The tumor was...
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| Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2002-07, Vol.126 (7), p.849-852 |
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| container_title | Archives of pathology & laboratory medicine (1976) |
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| creator | Wajstaub, Sandra Deb, Pratima Chorneyko, Katherine A |
| description | Malignant spindle cell tumors of the parotid gland are a diagnostic challenge. We present an unusual case of such a tumor that occurred in the right parotid gland of a 53-year-old man. The clinical and histologic assessments were consistent with a primary sarcoma of the parotid gland. The tumor was composed of sheets of pleomorphic, spindle-shaped cells with an area of bone formation. By immunohistochemistry, the tumor cells were positive for vimentin and negative for epithelial markers. Electron microscopy revealed mesenchymal cells containing moderate amounts of rough endoplasmic reticulum. The major differential diagnostic considerations were spindle cell carcinoma, carcinosarcoma, and primary undifferentiated sarcoma with osseous metaplasia. The lack of epithelial features and the benign appearance of the bone formation led to a diagnosis of undifferentiated sarcoma of the parotid gland. |
| doi_str_mv | 10.5858/2002-126-0849-USOTPG |
| format | Article |
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We present an unusual case of such a tumor that occurred in the right parotid gland of a 53-year-old man. The clinical and histologic assessments were consistent with a primary sarcoma of the parotid gland. The tumor was composed of sheets of pleomorphic, spindle-shaped cells with an area of bone formation. By immunohistochemistry, the tumor cells were positive for vimentin and negative for epithelial markers. Electron microscopy revealed mesenchymal cells containing moderate amounts of rough endoplasmic reticulum. The major differential diagnostic considerations were spindle cell carcinoma, carcinosarcoma, and primary undifferentiated sarcoma with osseous metaplasia. 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We present an unusual case of such a tumor that occurred in the right parotid gland of a 53-year-old man. The clinical and histologic assessments were consistent with a primary sarcoma of the parotid gland. The tumor was composed of sheets of pleomorphic, spindle-shaped cells with an area of bone formation. By immunohistochemistry, the tumor cells were positive for vimentin and negative for epithelial markers. Electron microscopy revealed mesenchymal cells containing moderate amounts of rough endoplasmic reticulum. The major differential diagnostic considerations were spindle cell carcinoma, carcinosarcoma, and primary undifferentiated sarcoma with osseous metaplasia. The lack of epithelial features and the benign appearance of the bone formation led to a diagnosis of undifferentiated sarcoma of the parotid gland.</description><subject>Biomarkers, Tumor - analysis</subject><subject>Cancer</subject><subject>Carcinoma - pathology</subject><subject>Carcinosarcoma - pathology</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Endoplasmic Reticulum, Rough - ultrastructure</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Ossification, Heterotopic - complications</subject><subject>Ossification, Heterotopic - metabolism</subject><subject>Ossification, Heterotopic - pathology</subject><subject>Parotid Neoplasms - chemistry</subject><subject>Parotid Neoplasms - complications</subject><subject>Parotid Neoplasms - pathology</subject><subject>Radiotherapy</subject><subject>Salivary gland tumors</subject><subject>Sarcoma - chemistry</subject><subject>Sarcoma - complications</subject><subject>Sarcoma - pathology</subject><subject>Vimentin - analysis</subject><issn>0003-9985</issn><issn>1543-2165</issn><issn>1543-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkl9rFDEUxYModlv9BiKDQt-mJpnJn3kspa1CoYLd53A3c7ObMjNZkwzitzfDLmhlycMl4Xcu5-YeQj4weiW00F84pbxmXNZUt129_vH49P3-FVkx0TY1Z1K8JitKaVN3nRZn5Dyl53LtOGdvyRnjVOtWqBW5XU-9dw4jTtlDxr5KEG0YoQquyjus9hBD9n21HWDqq18-76qQEoY5VSNm2A-QPLwjbxwMCd8f6wVZ390-3XytHx7vv91cP9S2lTLXjRa9tFS0ygrHFAJXivIWNlZq0I0E0L2zzvaMbbhELlBBa11LF1CWYS7I5aHvPoafM6ZsRp8sDsXb4sgophVrtCzgp__A5zDHqXgzvAwvG6YW6PMB2sKAxk8u5Ah26WiuhSjWRNcsVH2C2uKEEYYwofPl-QV_dYIvp8fR25OCy38EO4Qh71IY5uzDlF6C7QG0sawgojP76EeIvw2jZsmEWTJhSibMkglzyESRfTz-xbwZsf8rOoag-QPLKa-l</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Wajstaub, Sandra</creator><creator>Deb, Pratima</creator><creator>Chorneyko, Katherine A</creator><general>College of American Pathologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Undifferentiated sarcoma of the parotid gland with osseous metaplasia</title><author>Wajstaub, Sandra ; 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The lack of epithelial features and the benign appearance of the bone formation led to a diagnosis of undifferentiated sarcoma of the parotid gland.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>12088457</pmid><doi>10.5858/2002-126-0849-USOTPG</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biomarkers, Tumor - analysis Cancer Carcinoma - pathology Carcinosarcoma - pathology Care and treatment Case studies Chemotherapy Diagnosis Diagnosis, Differential Endoplasmic Reticulum, Rough - ultrastructure Humans Immunohistochemistry Male Metaplasia Middle Aged Ossification, Heterotopic - complications Ossification, Heterotopic - metabolism Ossification, Heterotopic - pathology Parotid Neoplasms - chemistry Parotid Neoplasms - complications Parotid Neoplasms - pathology Radiotherapy Salivary gland tumors Sarcoma - chemistry Sarcoma - complications Sarcoma - pathology Vimentin - analysis |
| title | Undifferentiated sarcoma of the parotid gland with osseous metaplasia |
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