Adenosine Deaminase Inhibition Attenuates Microvascular Dysfunction and Improves Survival in Sepsis

The ability of increased endogenous adenosine to mitigate microvascular derangements in sepsis was studied. Pentostatin (2'-deoxycoformycin), an inhibitor of adenosine deaminase, was administered to mice immediately after induction of sepsis by cecal ligation and puncture. Intravital video micr...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2002-07, Vol.166 (1), p.16-20
Hauptverfasser:	Cohen, Elliott S, Law, William R, Easington, Cordus R, Cruz, Kenneth Q, Nardulli, Beth A, Balk, Robert A, Parrillo, Joseph E, Hollenberg, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - drug effects Adenosine Deaminase Inhibitors Analysis of Variance Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Capillary Permeability - drug effects Endothelium, Vascular - drug effects Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use General aspects Leukocytes - drug effects Male Medical sciences Mice Mice, Inbred BALB C Pentostatin - pharmacology Pentostatin - therapeutic use Pharmacology. Drug treatments Sepsis - drug therapy Sepsis - physiopathology Survival Analysis
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