Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X
We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 0...
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| Veröffentlicht in: | Neuroscience letters 2002-07, Vol.327 (2), p.143-145 |
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| container_title | Neuroscience letters |
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| creator | Altun, Armagan Yaprak, Mevlut Aktoz, Meryem Vardar, Arzu Betul, Ugur-Altun Ozbay, Gultac |
| description | We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (
P=0.04). Peak and Δ melatonin (peak–lowest melatonin) were found lower in patients with cardiac syndrome X (
P=0.039 and
P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients. |
| doi_str_mv | 10.1016/S0304-3940(02)00368-3 |
| format | Article |
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P=0.04). Peak and Δ melatonin (peak–lowest melatonin) were found lower in patients with cardiac syndrome X (
P=0.039 and
P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(02)00368-3</identifier><identifier>PMID: 12098655</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Angina ; Biological and medical sciences ; Cardiology. Vascular system ; Circadian Rhythm ; Coronary heart disease ; Female ; Heart ; Humans ; Male ; Medical sciences ; Melatonin - biosynthesis ; Melatonin - blood ; Microvascular Angina - metabolism ; Middle Aged ; Nervous system ; Normal coronary angiography ; Pineal Gland - metabolism ; Sympathetic Nervous System - physiology ; Sympathovagal imbalance ; Vagus Nerve - physiology</subject><ispartof>Neuroscience letters, 2002-07, Vol.327 (2), p.143-145</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-809bd0923f49dbd75685ce78250dd330597bf3424b3abdc091825dace38755a3</citedby><cites>FETCH-LOGICAL-c443t-809bd0923f49dbd75685ce78250dd330597bf3424b3abdc091825dace38755a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394002003683$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13763746$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12098655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altun, Armagan</creatorcontrib><creatorcontrib>Yaprak, Mevlut</creatorcontrib><creatorcontrib>Aktoz, Meryem</creatorcontrib><creatorcontrib>Vardar, Arzu</creatorcontrib><creatorcontrib>Betul, Ugur-Altun</creatorcontrib><creatorcontrib>Ozbay, Gultac</creatorcontrib><title>Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (
P=0.04). Peak and Δ melatonin (peak–lowest melatonin) were found lower in patients with cardiac syndrome X (
P=0.039 and
P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients.</description><subject>Adult</subject><subject>Angina</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Circadian Rhythm</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin - biosynthesis</subject><subject>Melatonin - blood</subject><subject>Microvascular Angina - metabolism</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Normal coronary angiography</subject><subject>Pineal Gland - metabolism</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Sympathovagal imbalance</subject><subject>Vagus Nerve - physiology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1PwyAYwHFiNG5OP4KmF40eqk8LlPZkzOLLkhkP7uCNUKAZpi8TqGbfXrY17mhCwoH_A-SH0HkCtwkk2d07YCAxLghcQ3oDgLM8xgdonOQsjVnB0kM0_ktG6MS5TwCgCSXHaJSkUOQZpWP0OmtWwlitoraTvretqCO3bv1SO-OirooaXQvftaaNwloJb3TrXfRj_DKSwioj5KZXtmt09HGKjipRO3027BO0eHpcTF_i-dvzbPowjyUh2Mc5FKWCIsUVKVSpGM1yKjXLUwpKYQy0YGWFSUpKLEoloUjCkRJS45xRKvAEXe2uXdnuq9fO88Y4qetatLrrHWcBISDlIaS7UNrOOasrvrKmEXbNE-AbRr5l5BsjDinfMnIc5i6GB_qy0Wo_NbiF4HIIhJOirqxopXH7DrMMM5KF7n7X6aDxbbTlTgZBqVUwl56rzvzzlV8AP469</recordid><startdate>20020719</startdate><enddate>20020719</enddate><creator>Altun, Armagan</creator><creator>Yaprak, Mevlut</creator><creator>Aktoz, Meryem</creator><creator>Vardar, Arzu</creator><creator>Betul, Ugur-Altun</creator><creator>Ozbay, Gultac</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020719</creationdate><title>Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X</title><author>Altun, Armagan ; Yaprak, Mevlut ; Aktoz, Meryem ; Vardar, Arzu ; Betul, Ugur-Altun ; Ozbay, Gultac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-809bd0923f49dbd75685ce78250dd330597bf3424b3abdc091825dace38755a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Angina</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Circadian Rhythm</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melatonin - biosynthesis</topic><topic>Melatonin - blood</topic><topic>Microvascular Angina - metabolism</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Normal coronary angiography</topic><topic>Pineal Gland - metabolism</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Sympathovagal imbalance</topic><topic>Vagus Nerve - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altun, Armagan</creatorcontrib><creatorcontrib>Yaprak, Mevlut</creatorcontrib><creatorcontrib>Aktoz, Meryem</creatorcontrib><creatorcontrib>Vardar, Arzu</creatorcontrib><creatorcontrib>Betul, Ugur-Altun</creatorcontrib><creatorcontrib>Ozbay, Gultac</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altun, Armagan</au><au>Yaprak, Mevlut</au><au>Aktoz, Meryem</au><au>Vardar, Arzu</au><au>Betul, Ugur-Altun</au><au>Ozbay, Gultac</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2002-07-19</date><risdate>2002</risdate><volume>327</volume><issue>2</issue><spage>143</spage><epage>145</epage><pages>143-145</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (
P=0.04). Peak and Δ melatonin (peak–lowest melatonin) were found lower in patients with cardiac syndrome X (
P=0.039 and
P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12098655</pmid><doi>10.1016/S0304-3940(02)00368-3</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2002-07, Vol.327 (2), p.143-145 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Angina Biological and medical sciences Cardiology. Vascular system Circadian Rhythm Coronary heart disease Female Heart Humans Male Medical sciences Melatonin - biosynthesis Melatonin - blood Microvascular Angina - metabolism Middle Aged Nervous system Normal coronary angiography Pineal Gland - metabolism Sympathetic Nervous System - physiology Sympathovagal imbalance Vagus Nerve - physiology |
| title | Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X |
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