Platelet derived growth factor (PDGF)-induced reactive oxygen species in the lens epithelial cells: the redox signaling

Low level of reactive oxygen species (ROS) has been shown to play an important role in host defense and mediating mitogen-stimulated cell signaling in several cell types. This study is to identify the mitogen-induced endogenous ROS generation and the range of exogenous H 2O 2 that initiate redox sig...

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Veröffentlicht in:	Experimental eye research 2004-06, Vol.78 (6), p.1057-1067
Hauptverfasser:	Chao-Wei Chen, Kate, Zhou, You, Xing, Kuiyi, Krysan, Kostantyn, Lou, Marjorie F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Catalase - metabolism Catalase - pharmacology Cell Division - drug effects cell proliferation Cells, Cultured EGF Epithelial Cells - drug effects Epithelial Cells - metabolism growth factors Humans Hydrogen Peroxide - pharmacology JNK Lens, Crystalline - drug effects Lens, Crystalline - metabolism Mannitol - pharmacology MAPkinase Microscopy, Confocal Microscopy, Fluorescence Mitogen-Activated Protein Kinases - metabolism Oxidation-Reduction - drug effects p38 PDGF phosphorylation Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - pharmacology reactive oxygen species (ROS) Reactive Oxygen Species - metabolism redox signaling Signal Transduction
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