Links between innate and adaptive immunity via type I interferon
Type I interferon (IFN-α/β) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-α/β and undergo maturation in response to IFN-α/β. Moreover,...
Gespeichert in:
| Veröffentlicht in: | Current Opinion in Immunology 2002-08, Vol.14 (4), p.432-436 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 436 |
|---|---|
| container_issue | 4 |
| container_start_page | 432 |
| container_title | Current Opinion in Immunology |
| container_volume | 14 |
| creator | Le Bon, Agnes Tough, David F |
| description | Type I interferon (IFN-α/β) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-α/β and undergo maturation in response to IFN-α/β. Moreover, IFN-α/β has been shown to potently enhance immune responses
in vivo through the stimulation of dendritic cells. These findings indicate that IFN-α/β serves as a signal linking innate and adaptive immunity.
Recent evidence shows that type I interferon plays an important role in linking innate and adaptive immunity, enhancing immune responses through the stimulation of dendritic cells. |
| doi_str_mv | 10.1016/S0952-7915(02)00354-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71869048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0952791502003540</els_id><sourcerecordid>71869048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-ee3c0fa0bb90307d3d37d7e92fb96a0593757298139b719965e85f81e30f91ed3</originalsourceid><addsrcrecordid>eNqF0D1PwzAQgGELgaAUfgIoE4IhcI7j2J4AIT4qVWIAZsuJL5KhcYrtFPXf09IKRqZbnruTXkJOKFxSoNXVCyhe5EJRfg7FBQDjZQ47ZESlUDkwUeyS0S85IIcxvgMA5wz2yQEtQMpKVCNyM3X-I2Y1pi9EnznvTcLMeJsZa-bJLTBzXTd4l5bZwpksLeeYTVYuYWgx9P6I7LVmFvF4O8fk7eH-9e4pnz4_Tu5up3lTlmXKEVkDrYG6VsBAWGaZsAJV0daqMsAVE1wUSlKmakGVqjhK3kqKDFpF0bIxOdvcnYf-c8CYdOdig7OZ8dgPUQsqKwWl_BdSWTIhizXkG9iEPsaArZ4H15mw1BT0urH-aazXATUU-qexhtXe6fbBUHdo_7a2UVfgegNw1WPhMOjYOPQNWhewSdr27p8X33XBilA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18437828</pqid></control><display><type>article</type><title>Links between innate and adaptive immunity via type I interferon</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Le Bon, Agnes ; Tough, David F</creator><creatorcontrib>Le Bon, Agnes ; Tough, David F</creatorcontrib><description>Type I interferon (IFN-α/β) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-α/β and undergo maturation in response to IFN-α/β. Moreover, IFN-α/β has been shown to potently enhance immune responses
in vivo through the stimulation of dendritic cells. These findings indicate that IFN-α/β serves as a signal linking innate and adaptive immunity.
Recent evidence shows that type I interferon plays an important role in linking innate and adaptive immunity, enhancing immune responses through the stimulation of dendritic cells.</description><identifier>ISSN: 0952-7915</identifier><identifier>EISSN: 1879-0372</identifier><identifier>DOI: 10.1016/S0952-7915(02)00354-0</identifier><identifier>PMID: 12088676</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adjuvant ; Adjuvants, Immunologic - physiology ; Animals ; dendritic cells ; Dendritic Cells - immunology ; Humans ; Immunity, Innate ; Infection - immunology ; innate immunity ; Interferon Type I - physiology ; Lymphocyte Activation ; Models, Immunological ; natural interferon-producing cells ; Type I interferon</subject><ispartof>Current Opinion in Immunology, 2002-08, Vol.14 (4), p.432-436</ispartof><rights>2002 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-ee3c0fa0bb90307d3d37d7e92fb96a0593757298139b719965e85f81e30f91ed3</citedby><cites>FETCH-LOGICAL-c444t-ee3c0fa0bb90307d3d37d7e92fb96a0593757298139b719965e85f81e30f91ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0952-7915(02)00354-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3550,27922,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12088676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Bon, Agnes</creatorcontrib><creatorcontrib>Tough, David F</creatorcontrib><title>Links between innate and adaptive immunity via type I interferon</title><title>Current Opinion in Immunology</title><addtitle>Curr Opin Immunol</addtitle><description>Type I interferon (IFN-α/β) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-α/β and undergo maturation in response to IFN-α/β. Moreover, IFN-α/β has been shown to potently enhance immune responses
in vivo through the stimulation of dendritic cells. These findings indicate that IFN-α/β serves as a signal linking innate and adaptive immunity.
Recent evidence shows that type I interferon plays an important role in linking innate and adaptive immunity, enhancing immune responses through the stimulation of dendritic cells.</description><subject>adjuvant</subject><subject>Adjuvants, Immunologic - physiology</subject><subject>Animals</subject><subject>dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Infection - immunology</subject><subject>innate immunity</subject><subject>Interferon Type I - physiology</subject><subject>Lymphocyte Activation</subject><subject>Models, Immunological</subject><subject>natural interferon-producing cells</subject><subject>Type I interferon</subject><issn>0952-7915</issn><issn>1879-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0D1PwzAQgGELgaAUfgIoE4IhcI7j2J4AIT4qVWIAZsuJL5KhcYrtFPXf09IKRqZbnruTXkJOKFxSoNXVCyhe5EJRfg7FBQDjZQ47ZESlUDkwUeyS0S85IIcxvgMA5wz2yQEtQMpKVCNyM3X-I2Y1pi9EnznvTcLMeJsZa-bJLTBzXTd4l5bZwpksLeeYTVYuYWgx9P6I7LVmFvF4O8fk7eH-9e4pnz4_Tu5up3lTlmXKEVkDrYG6VsBAWGaZsAJV0daqMsAVE1wUSlKmakGVqjhK3kqKDFpF0bIxOdvcnYf-c8CYdOdig7OZ8dgPUQsqKwWl_BdSWTIhizXkG9iEPsaArZ4H15mw1BT0urH-aazXATUU-qexhtXe6fbBUHdo_7a2UVfgegNw1WPhMOjYOPQNWhewSdr27p8X33XBilA</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Le Bon, Agnes</creator><creator>Tough, David F</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Links between innate and adaptive immunity via type I interferon</title><author>Le Bon, Agnes ; Tough, David F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-ee3c0fa0bb90307d3d37d7e92fb96a0593757298139b719965e85f81e30f91ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>adjuvant</topic><topic>Adjuvants, Immunologic - physiology</topic><topic>Animals</topic><topic>dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Infection - immunology</topic><topic>innate immunity</topic><topic>Interferon Type I - physiology</topic><topic>Lymphocyte Activation</topic><topic>Models, Immunological</topic><topic>natural interferon-producing cells</topic><topic>Type I interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Bon, Agnes</creatorcontrib><creatorcontrib>Tough, David F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Bon, Agnes</au><au>Tough, David F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Links between innate and adaptive immunity via type I interferon</atitle><jtitle>Current Opinion in Immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>14</volume><issue>4</issue><spage>432</spage><epage>436</epage><pages>432-436</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><abstract>Type I interferon (IFN-α/β) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-α/β and undergo maturation in response to IFN-α/β. Moreover, IFN-α/β has been shown to potently enhance immune responses
in vivo through the stimulation of dendritic cells. These findings indicate that IFN-α/β serves as a signal linking innate and adaptive immunity.
Recent evidence shows that type I interferon plays an important role in linking innate and adaptive immunity, enhancing immune responses through the stimulation of dendritic cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12088676</pmid><doi>10.1016/S0952-7915(02)00354-0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-7915 |
| ispartof | Current Opinion in Immunology, 2002-08, Vol.14 (4), p.432-436 |
| issn | 0952-7915 1879-0372 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71869048 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | adjuvant Adjuvants, Immunologic - physiology Animals dendritic cells Dendritic Cells - immunology Humans Immunity, Innate Infection - immunology innate immunity Interferon Type I - physiology Lymphocyte Activation Models, Immunological natural interferon-producing cells Type I interferon |
| title | Links between innate and adaptive immunity via type I interferon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T06%3A25%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Links%20between%20innate%20and%20adaptive%20immunity%20via%20type%20I%20interferon&rft.jtitle=Current%20Opinion%20in%20Immunology&rft.au=Le%20Bon,%20Agnes&rft.date=2002-08-01&rft.volume=14&rft.issue=4&rft.spage=432&rft.epage=436&rft.pages=432-436&rft.issn=0952-7915&rft.eissn=1879-0372&rft_id=info:doi/10.1016/S0952-7915(02)00354-0&rft_dat=%3Cproquest_cross%3E71869048%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18437828&rft_id=info:pmid/12088676&rft_els_id=S0952791502003540&rfr_iscdi=true |