p53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex

We have previously reported that human matrix metalloproteinase‐1 (MMP1) is a p53 target gene subject to down‐regulation (Sun et al. [1999]: J Biol Chem 274:11535–11540]. In the present study, we demonstrate that the down‐regulation of the human −83MMP1 promoter fragment by p53 was abolished when th...

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