Tonically active GABA A receptors: modulating gain and maintaining the tone

GABA A receptors not only respond to the local release of GABA from presynaptic terminals, but can also mediate a persistent ‘tonic current’. This reflects the activation of high-affinity GABA A receptors by ambient GABA concentrations. Tonic GABA A-receptor-mediated signalling occurs in different b...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2004-05, Vol.27 (5), p.262-269
Hauptverfasser:	Semyanov, Alexey, Walker, Matthew C., Kullmann, Dimitri M., Silver, R.Angus
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Brain - cytology Cells, Cultured gamma-Aminobutyric Acid - metabolism Models, Neurological Nerve Net - physiology Neural Inhibition - physiology Neurons - classification Neurons - cytology Neurons - physiology Presynaptic Terminals - metabolism Receptors, GABA-A - classification Receptors, GABA-A - physiology
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