Tonically active GABA A receptors: modulating gain and maintaining the tone
GABA A receptors not only respond to the local release of GABA from presynaptic terminals, but can also mediate a persistent ‘tonic current’. This reflects the activation of high-affinity GABA A receptors by ambient GABA concentrations. Tonic GABA A-receptor-mediated signalling occurs in different b...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2004-05, Vol.27 (5), p.262-269 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | Semyanov, Alexey Walker, Matthew C. Kullmann, Dimitri M. Silver, R.Angus |
| description | GABA
A receptors not only respond to the local release of GABA from presynaptic terminals, but can also mediate a persistent ‘tonic current’. This reflects the activation of high-affinity GABA
A receptors by ambient GABA concentrations. Tonic GABA
A-receptor-mediated signalling occurs in different brain regions, shows cell-type-specific differences in magnitude and pharmacology, and changes during brain development. Some clues to the adaptive significance of this phenomenon are beginning to emerge: in cerebellar granule cells, it alters the gain of transmission of rate-coded sensory information; in the hippocampus, it acts in a cell-type-specific manner to regulate the excitability of the network. Because tonic conductances can be modulated by changes in GABA release and uptake, and by modulators of high-affinity GABA
A receptors including neurosteroids, this phenomenon provides a potentially important new window onto neuronal information processing and pathological states such as epilepsy. |
| doi_str_mv | 10.1016/j.tins.2004.03.005 |
| format | Article |
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A receptors not only respond to the local release of GABA from presynaptic terminals, but can also mediate a persistent ‘tonic current’. This reflects the activation of high-affinity GABA
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| identifier | ISSN: 0166-2236 |
| ispartof | Trends in neurosciences (Regular ed.), 2004-05, Vol.27 (5), p.262-269 |
| issn | 0166-2236 1878-108X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Action Potentials - physiology Animals Brain - cytology Cells, Cultured gamma-Aminobutyric Acid - metabolism Models, Neurological Nerve Net - physiology Neural Inhibition - physiology Neurons - classification Neurons - cytology Neurons - physiology Presynaptic Terminals - metabolism Receptors, GABA-A - classification Receptors, GABA-A - physiology |
| title | Tonically active GABA A receptors: modulating gain and maintaining the tone |
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