Release of Intact and Fragmented Osteocalcin Molecules from Bone Matrix during Bone Resorption in Vitro

Osteocalcin detected from serum samples is considered a specific marker of osteoblast activity and bone formation rate. However, osteocalcin embedded in bone matrix must also be released during bone resorption. To understand the contribution of each type of bone cell in circulating osteocalcin level...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (18), p.18361-18369
Hauptverfasser:	Ivaska, Kaisa K, Hentunen, Teuvo A, Vääräniemi, Jukka, Ylipahkala, Hannele, Pettersson, Kim, Väänänen, H Kalervo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - analysis Bone and Bones - cytology Bone and Bones - metabolism Bone Matrix - metabolism Bone Resorption - metabolism Cattle Coculture Techniques Humans Immunoassay - standards Macrolides - pharmacology Osteocalcin - analysis Osteocalcin - metabolism Osteoclasts - cytology Osteoclasts - physiology Parathyroid Hormone - pharmacology Peptide Fragments - analysis Peptide Fragments - metabolism Rats Rats, Sprague-Dawley
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