Avoiding the kiss of death: how HIV and other chronic viruses survive

Virus-specific CD8 T cells during chronic infection often exceed in numbers virus-replicating infected cells. Why then do antiviral CD8 T cells not do a better job of controlling infection? Although viral strategies for immune evasion are well known, this review will focus on changes in the CD8 T ce...

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Veröffentlicht in:	Current Opinion in Immunology 2002-08, Vol.14 (4), p.478-486
Hauptverfasser:	Lieberman, Judy, Manjunath, N, Shankar, Premlata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCR7 CD27 CD8 T lymphocyte Cell Differentiation Chronic Disease Clonal Anergy CMV cytotoxicity Disease Models, Animal EBV HIV HIV Infections - immunology Humans interferon-g Membrane Glycoproteins - physiology Mice Models, Immunological Perforin Pore Forming Cytotoxic Proteins Simian Acquired Immunodeficiency Syndrome - immunology T-Lymphocytes, Cytotoxic - immunology Virus Diseases - immunology Viruses - pathogenicity
Online-Zugang:	Volltext
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