Ca2+ and N-Ethylmaleimide-sensitive Factor Differentially Regulate Disassembly of SNARE Complexes on Early Endosomes

The endosome-associated protein Hrs inhibits the homotypic fusion of early endosomes. A helical region of Hrs containing a Q-SNARE motif mediates this effect as well as its endosomal membrane association via SNAP-25, an endosomal receptor for Hrs. Hrs inhibits formation of an early endosomal SNARE c...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (18), p.18270-18276
Hauptverfasser:	Yan, Qing, Sun, Wei, McNew, James A, Vida, Thomas A, Bean, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - pharmacology Carrier Proteins - physiology Endosomal Sorting Complexes Required for Transport Endosomes - chemistry Endosomes - metabolism HeLa Cells Humans Membrane Fusion Membrane Proteins - metabolism N-Ethylmaleimide-Sensitive Proteins Nerve Tissue Proteins - metabolism Phosphoproteins - physiology Protein Binding - drug effects Qa-SNARE Proteins R-SNARE Proteins SNARE Proteins Synaptosomal-Associated Protein 25 Vesicular Transport Proteins
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