Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair

Apurinic/apyrimidinic (AP) endonuclease (APE) is a multifunctional protein possessing both DNA repair and redox regulatory activities. In base excision repair (BER), APE is responsible for processing spontaneous, chemical, or monofunctional DNA glycosylase-initiated AP sites via its 5'-endonucl...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (18), p.18425-18433
Hauptverfasser:	Raffoul, Julian J, Cabelof, Diane C, Nakamura, Jun, Meira, Lisiane B, Friedberg, Errol C, Heydari, Ahmad R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Pair Mismatch Binding Sites Brain - metabolism DNA Polymerase beta - metabolism DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - deficiency DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics Haplotypes Heterozygote Liver - metabolism Male Mice Mice, Knockout Organ Specificity Oxidation-Reduction Testis - metabolism
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