Structure–activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

The minimum structural requirements for troglitazone-like compounds to retain their biological activities were reported. Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (10), p.2547-2550
Hauptverfasser:	Fan, Yun-Hua, Chen, Han, Natarajan, Amarnath, Guo, Yuhong, Harbinski, Fred, Iyasere, Julia, Christ, William, Aktas, Huseyin, Halperin, Jose A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Calcium - metabolism Cell Line, Tumor Cell Proliferation - drug effects Chromans - chemical synthesis Chromans - pharmacology Eukaryotic Initiation Factor-2 - metabolism General aspects Humans Intracellular calcium Medical sciences Pharmacology. Drug treatments Phosphorylation - drug effects Protein Biosynthesis - drug effects Structure-Activity Relationship Thiazolidinediones Thiazolidinediones - chemical synthesis Thiazolidinediones - pharmacology Troglitazone
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