3-Isobutyl-1-methylxanthine (IBMX) sensitizes cardiac myocytes to anoxia

Cardiac myocytes incubated with 3-isobutyl-1-methylxanthine (IBMX), a nonspecific cyclic nucleotide phosphodiesterase inhibitor, formed rigor complexes under anoxic conditions more readily than cells incubated with other phosphodiesterase inhibitors. Cardiac myocytes were incubated for 1 hr with eit...

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Veröffentlicht in:	Biochemical pharmacology 2002-06, Vol.63 (11), p.2055-2062
Hauptverfasser:	Geisbuhler, Timothy P., Schwager, Tammie L., Ervin, Heather D.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3-Isobutyl-1-methylxanthine 8-Cyclopentyl-1,3-dipropylxanthine Animals Anoxia Antiarythmic agents ATP/ADP ratio Biological and medical sciences Cardiovascular system Cell Hypoxia Cell physiology Effects of physical and chemical agents Fundamental and applied biological sciences. Psychology Heart Heart - drug effects Heart - physiology Hypoxia - metabolism Medical sciences Molecular and cellular biology Myocardium - metabolism Myocyte Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Rats Verapamil Zaprinast
Online-Zugang:	Volltext
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