Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor

The migration of multiple myeloma (MM) cells from the circulation into the bone marrow (BM) implicates that they must have the capacity to cross the BM endothelium including the subendothelial basement membrane. In this study, human CD138 + MM cells were immunomagnetically isolated from BM samples o...

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Veröffentlicht in:	Leukemia 2004-05, Vol.18 (5), p.976-982
Hauptverfasser:	Vande Broek, I, Asosingh, K, Allegaert, V, Leleu, X, Facon, T, Vanderkerken, K, Van Camp, B, Van Riet, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antibodies Basements Biological and medical sciences Blood vessels Bone marrow Bone Marrow Cells - physiology Cancer Research Cells Cells, Cultured Critical Care Medicine Cytokines Endothelial cells Endothelial Cells - physiology Endothelium Gelatinase B Growth factors Hematologic and hematopoietic diseases Hematology Hepatocyte growth factor Hepatocyte Growth Factor - physiology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunology Immunopathology Intensive Internal Medicine Invasiveness Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes Matrix metalloproteinase Matrix Metalloproteinase 9 - physiology Matrix metalloproteinases Medical sciences Medicine Medicine & Public Health Membranes Metalloproteinase Multiple myeloma Multiple Myeloma - enzymology Multiple Myeloma - pathology Neoplasm Invasiveness Oncology original-manuscript Pathogenesis Stimulation Up-Regulation
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