Furanones as potential anti-bacterial coatings on biomaterials
A major barrier to the long-term use of medical devices is development of infection. Staphylococcus epidermidis is one of the most common bacterial isolates from these infections with biofilm formation being their main virulence factor. Currently, antibiotics are used as the main form of therapy. Ho...
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| Veröffentlicht in: | Biomaterials 2004-09, Vol.25 (20), p.5003-5012 |
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| creator | Baveja, J.K Willcox, M.D.P Hume, E.B.H Kumar, N Odell, R Poole-Warren, L.A |
| description | A major barrier to the long-term use of medical devices is development of infection.
Staphylococcus epidermidis is one of the most common bacterial isolates from these infections with biofilm formation being their main virulence factor. Currently, antibiotics are used as the main form of therapy. However with the emergence of staphylococcal resistance, this form of therapy is fast becoming ineffective. In this study, the ability of a novel furanone antimicrobial compound to inhibit
S. epidermidis adhesion and slime production on biomaterials was assessed. Furanones were physically adsorbed to various biomaterials and bacterial load determined using radioactivity. Slime production was assessed using a colorimetric method. Additionally, the effect of the furanone coating on material surface characteristics such as hydrophobicity and surface roughness was also investigated. The results of this study indicated that there was no significant change in the material characteristics after furanone coating. Bacterial load on all furanone-coated materials was significantly reduced (
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| doi_str_mv | 10.1016/j.biomaterials.2004.02.051 |
| format | Article |
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Staphylococcus epidermidis is one of the most common bacterial isolates from these infections with biofilm formation being their main virulence factor. Currently, antibiotics are used as the main form of therapy. However with the emergence of staphylococcal resistance, this form of therapy is fast becoming ineffective. In this study, the ability of a novel furanone antimicrobial compound to inhibit
S. epidermidis adhesion and slime production on biomaterials was assessed. Furanones were physically adsorbed to various biomaterials and bacterial load determined using radioactivity. Slime production was assessed using a colorimetric method. Additionally, the effect of the furanone coating on material surface characteristics such as hydrophobicity and surface roughness was also investigated. The results of this study indicated that there was no significant change in the material characteristics after furanone coating. Bacterial load on all furanone-coated materials was significantly reduced (
p<0.001) as was slime production (
p<0.001). There is a potential for furanone-coated biomaterials to be used to reduce medical device-associated infections.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2004.02.051</identifier><identifier>PMID: 15109862</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Anti-bacterial ; Anti-Bacterial Agents - pharmacology ; Bacterial Adhesion ; Biocompatible Materials ; Biofilm ; Biofilms ; Biomaterials ; Cell Adhesion ; Cell Line ; Cell Proliferation ; Ethanol - pharmacology ; Furans - chemistry ; Materials Testing ; Mice ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; Models, Chemical ; Polymers - chemistry ; Silicon - chemistry ; Spectrometry, X-Ray Emission ; Staphylococcus epidermidis ; Staphylococcus epidermidis - metabolism ; Stress, Mechanical ; Surface modification ; Surface Properties ; Tensile Strength ; Time Factors</subject><ispartof>Biomaterials, 2004-09, Vol.25 (20), p.5003-5012</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-4e12b6be87641746bd8777cec4dfb48145a6dc7f81788f90009109083bc98c023</citedby><cites>FETCH-LOGICAL-c407t-4e12b6be87641746bd8777cec4dfb48145a6dc7f81788f90009109083bc98c023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961204002005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15109862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baveja, J.K</creatorcontrib><creatorcontrib>Willcox, M.D.P</creatorcontrib><creatorcontrib>Hume, E.B.H</creatorcontrib><creatorcontrib>Kumar, N</creatorcontrib><creatorcontrib>Odell, R</creatorcontrib><creatorcontrib>Poole-Warren, L.A</creatorcontrib><title>Furanones as potential anti-bacterial coatings on biomaterials</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>A major barrier to the long-term use of medical devices is development of infection.
Staphylococcus epidermidis is one of the most common bacterial isolates from these infections with biofilm formation being their main virulence factor. Currently, antibiotics are used as the main form of therapy. However with the emergence of staphylococcal resistance, this form of therapy is fast becoming ineffective. In this study, the ability of a novel furanone antimicrobial compound to inhibit
S. epidermidis adhesion and slime production on biomaterials was assessed. Furanones were physically adsorbed to various biomaterials and bacterial load determined using radioactivity. Slime production was assessed using a colorimetric method. Additionally, the effect of the furanone coating on material surface characteristics such as hydrophobicity and surface roughness was also investigated. The results of this study indicated that there was no significant change in the material characteristics after furanone coating. Bacterial load on all furanone-coated materials was significantly reduced (
p<0.001) as was slime production (
p<0.001). There is a potential for furanone-coated biomaterials to be used to reduce medical device-associated infections.</description><subject>Animals</subject><subject>Anti-bacterial</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Adhesion</subject><subject>Biocompatible Materials</subject><subject>Biofilm</subject><subject>Biofilms</subject><subject>Biomaterials</subject><subject>Cell Adhesion</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Ethanol - pharmacology</subject><subject>Furans - chemistry</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Microscopy, Atomic Force</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Chemical</subject><subject>Polymers - chemistry</subject><subject>Silicon - chemistry</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Staphylococcus epidermidis</subject><subject>Staphylococcus epidermidis - metabolism</subject><subject>Stress, Mechanical</subject><subject>Surface modification</subject><subject>Surface Properties</subject><subject>Tensile Strength</subject><subject>Time Factors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFLwzAUx4Mobk6_ghQP3lpfsrRJPQgynQoDL3oOafoqGWszk1bw25vRgbvp6U_g_94v70fIFYWMAi1u1lllXat79FZvQsYAeAYsg5wekSmVQqZ5CfkxmQLlLC0LyibkLIQ1xDdwdkomNKdQyoJNyd1y8LpzHYZEh2Treuz6uDXRMdJKmxGSGKd7232ExHXJIfycnDQx8GKfM_K-fHxbPKer16eXxf0qNRxEn3KkrCoqlKLgVPCiqqUQwqDhdVNxSXmui9qIRlIhZVMCQBk_CHJemVIaYPMZuR73br37HDD0qrXB4GajO3RDUILKIufy72IE8FyW81i8HYvGuxA8Nmrrbav9t6KgdprVWh1eqnaaFTAVNcfhyz1lqFqsf0f3XmPhYSxglPJl0atgLHYGa-vR9Kp29j-cHzKplK8</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Baveja, J.K</creator><creator>Willcox, M.D.P</creator><creator>Hume, E.B.H</creator><creator>Kumar, N</creator><creator>Odell, R</creator><creator>Poole-Warren, L.A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Furanones as potential anti-bacterial coatings on biomaterials</title><author>Baveja, J.K ; Willcox, M.D.P ; Hume, E.B.H ; Kumar, N ; Odell, R ; Poole-Warren, L.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-4e12b6be87641746bd8777cec4dfb48145a6dc7f81788f90009109083bc98c023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anti-bacterial</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Adhesion</topic><topic>Biocompatible Materials</topic><topic>Biofilm</topic><topic>Biofilms</topic><topic>Biomaterials</topic><topic>Cell Adhesion</topic><topic>Cell Line</topic><topic>Cell Proliferation</topic><topic>Ethanol - pharmacology</topic><topic>Furans - chemistry</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Microscopy, Atomic Force</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Chemical</topic><topic>Polymers - chemistry</topic><topic>Silicon - chemistry</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Staphylococcus epidermidis</topic><topic>Staphylococcus epidermidis - metabolism</topic><topic>Stress, Mechanical</topic><topic>Surface modification</topic><topic>Surface Properties</topic><topic>Tensile Strength</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baveja, J.K</creatorcontrib><creatorcontrib>Willcox, M.D.P</creatorcontrib><creatorcontrib>Hume, E.B.H</creatorcontrib><creatorcontrib>Kumar, N</creatorcontrib><creatorcontrib>Odell, R</creatorcontrib><creatorcontrib>Poole-Warren, L.A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baveja, J.K</au><au>Willcox, M.D.P</au><au>Hume, E.B.H</au><au>Kumar, N</au><au>Odell, R</au><au>Poole-Warren, L.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Furanones as potential anti-bacterial coatings on biomaterials</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>25</volume><issue>20</issue><spage>5003</spage><epage>5012</epage><pages>5003-5012</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>A major barrier to the long-term use of medical devices is development of infection.
Staphylococcus epidermidis is one of the most common bacterial isolates from these infections with biofilm formation being their main virulence factor. Currently, antibiotics are used as the main form of therapy. However with the emergence of staphylococcal resistance, this form of therapy is fast becoming ineffective. In this study, the ability of a novel furanone antimicrobial compound to inhibit
S. epidermidis adhesion and slime production on biomaterials was assessed. Furanones were physically adsorbed to various biomaterials and bacterial load determined using radioactivity. Slime production was assessed using a colorimetric method. Additionally, the effect of the furanone coating on material surface characteristics such as hydrophobicity and surface roughness was also investigated. The results of this study indicated that there was no significant change in the material characteristics after furanone coating. Bacterial load on all furanone-coated materials was significantly reduced (
p<0.001) as was slime production (
p<0.001). There is a potential for furanone-coated biomaterials to be used to reduce medical device-associated infections.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15109862</pmid><doi>10.1016/j.biomaterials.2004.02.051</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Anti-bacterial Anti-Bacterial Agents - pharmacology Bacterial Adhesion Biocompatible Materials Biofilm Biofilms Biomaterials Cell Adhesion Cell Line Cell Proliferation Ethanol - pharmacology Furans - chemistry Materials Testing Mice Microscopy, Atomic Force Microscopy, Electron, Scanning Models, Chemical Polymers - chemistry Silicon - chemistry Spectrometry, X-Ray Emission Staphylococcus epidermidis Staphylococcus epidermidis - metabolism Stress, Mechanical Surface modification Surface Properties Tensile Strength Time Factors |
| title | Furanones as potential anti-bacterial coatings on biomaterials |
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