Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies
A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with...
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| Veröffentlicht in: | Neurology 2004-04, Vol.62 (8), p.1402-1404 |
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| container_title | Neurology |
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| creator | MCCABE, D. J. H TURNER, N. C CHAO, D LEFF, A GREGSON, N. A WOMERSLEY, H. J MAK, I PERKIN, G. D SCHAPIRA, A. H. V |
| description | A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical. |
| doi_str_mv | 10.1212/01.WNL.0000123694.64121.D5 |
| format | Article |
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J. H ; TURNER, N. C ; CHAO, D ; LEFF, A ; GREGSON, N. A ; WOMERSLEY, H. J ; MAK, I ; PERKIN, G. D ; SCHAPIRA, A. H. V</creator><creatorcontrib>MCCABE, D. J. H ; TURNER, N. C ; CHAO, D ; LEFF, A ; GREGSON, N. A ; WOMERSLEY, H. J ; MAK, I ; PERKIN, G. D ; SCHAPIRA, A. H. V</creatorcontrib><description>A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.WNL.0000123694.64121.D5</identifier><identifier>PMID: 15111682</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - immunology ; Adenocarcinoma - secondary ; Adult ; Biological and medical sciences ; Carcinoembryonic Antigen - blood ; Deglutition Disorders - etiology ; Dysarthria - etiology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - immunology ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic Metastasis - immunology ; Medical sciences ; Muscle Weakness - etiology ; Muscle Weakness - physiopathology ; Neurology ; Neurons - immunology ; Palliative Care ; Paraneoplastic Syndromes, Nervous System - diagnosis ; Paraneoplastic Syndromes, Nervous System - immunology ; Radionuclide Imaging ; Spinal Cord - immunology ; Stiff-Person Syndrome - diagnosis ; Stiff-Person Syndrome - immunology ; Upper Extremity - physiopathology</subject><ispartof>Neurology, 2004-04, Vol.62 (8), p.1402-1404</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-dd743d77dbe08d8b3e33655c6a8700a9adf301404bedb7ac78038fcf8b2b34483</citedby><cites>FETCH-LOGICAL-c370t-dd743d77dbe08d8b3e33655c6a8700a9adf301404bedb7ac78038fcf8b2b34483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15806122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15111682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCCABE, D. J. H</creatorcontrib><creatorcontrib>TURNER, N. C</creatorcontrib><creatorcontrib>CHAO, D</creatorcontrib><creatorcontrib>LEFF, A</creatorcontrib><creatorcontrib>GREGSON, N. A</creatorcontrib><creatorcontrib>WOMERSLEY, H. J</creatorcontrib><creatorcontrib>MAK, I</creatorcontrib><creatorcontrib>PERKIN, G. D</creatorcontrib><creatorcontrib>SCHAPIRA, A. H. V</creatorcontrib><title>Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies</title><title>Neurology</title><addtitle>Neurology</addtitle><description>A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - secondary</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Deglutition Disorders - etiology</subject><subject>Dysarthria - etiology</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - immunology</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic Metastasis - immunology</subject><subject>Medical sciences</subject><subject>Muscle Weakness - etiology</subject><subject>Muscle Weakness - physiopathology</subject><subject>Neurology</subject><subject>Neurons - immunology</subject><subject>Palliative Care</subject><subject>Paraneoplastic Syndromes, Nervous System - diagnosis</subject><subject>Paraneoplastic Syndromes, Nervous System - immunology</subject><subject>Radionuclide Imaging</subject><subject>Spinal Cord - immunology</subject><subject>Stiff-Person Syndrome - diagnosis</subject><subject>Stiff-Person Syndrome - immunology</subject><subject>Upper Extremity - physiopathology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkNlKAzEUhoMotlZfQQZB72bMMpOk3knrBkVFFMWbkG0wMpvJFOnbm7YDNZDzX-Q755APgDMEM4QRvoQoe39cZDAehAmd5hnN40M2L_bAGBWYppTgj30whhDzlHDGR-AohO-IF5hND8EIFQghyvEYfD5LLxvbdpUMvdNJLGWZdNaHtknCqjG-rW3y6_qvpLZ9ZOSaksY2rZZeu6atZSIbE2_v0he3SdUaZ8MxOChlFezJkBPwdnvzOrtPF093D7PrRaoJg31qDMuJYcwoC7nhilhCaFFoKjmDUE6lKQlEOcyVNYpJzTgkvNQlV1iRPOdkAi62czvf_ixt6EXtgrZVtf7XMgiGOM1jieDVFtS-DcHbUnTe1dKvBIJibVZAJKJZsTMrNmbFvIjNp8OWpaqt2bUOKiNwPgAyaFmVUat24R_HIUUYkz-dtoOK</recordid><startdate>20040427</startdate><enddate>20040427</enddate><creator>MCCABE, D. J. H</creator><creator>TURNER, N. C</creator><creator>CHAO, D</creator><creator>LEFF, A</creator><creator>GREGSON, N. A</creator><creator>WOMERSLEY, H. J</creator><creator>MAK, I</creator><creator>PERKIN, G. D</creator><creator>SCHAPIRA, A. H. V</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040427</creationdate><title>Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies</title><author>MCCABE, D. J. H ; TURNER, N. C ; CHAO, D ; LEFF, A ; GREGSON, N. A ; WOMERSLEY, H. J ; MAK, I ; PERKIN, G. D ; SCHAPIRA, A. H. V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-dd743d77dbe08d8b3e33655c6a8700a9adf301404bedb7ac78038fcf8b2b34483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - secondary</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Deglutition Disorders - etiology</topic><topic>Dysarthria - etiology</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - immunology</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic Metastasis - immunology</topic><topic>Medical sciences</topic><topic>Muscle Weakness - etiology</topic><topic>Muscle Weakness - physiopathology</topic><topic>Neurology</topic><topic>Neurons - immunology</topic><topic>Palliative Care</topic><topic>Paraneoplastic Syndromes, Nervous System - diagnosis</topic><topic>Paraneoplastic Syndromes, Nervous System - immunology</topic><topic>Radionuclide Imaging</topic><topic>Spinal Cord - immunology</topic><topic>Stiff-Person Syndrome - diagnosis</topic><topic>Stiff-Person Syndrome - immunology</topic><topic>Upper Extremity - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCCABE, D. J. H</creatorcontrib><creatorcontrib>TURNER, N. C</creatorcontrib><creatorcontrib>CHAO, D</creatorcontrib><creatorcontrib>LEFF, A</creatorcontrib><creatorcontrib>GREGSON, N. A</creatorcontrib><creatorcontrib>WOMERSLEY, H. J</creatorcontrib><creatorcontrib>MAK, I</creatorcontrib><creatorcontrib>PERKIN, G. D</creatorcontrib><creatorcontrib>SCHAPIRA, A. H. V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCCABE, D. J. H</au><au>TURNER, N. C</au><au>CHAO, D</au><au>LEFF, A</au><au>GREGSON, N. A</au><au>WOMERSLEY, H. J</au><au>MAK, I</au><au>PERKIN, G. D</au><au>SCHAPIRA, A. H. V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2004-04-27</date><risdate>2004</risdate><volume>62</volume><issue>8</issue><spage>1402</spage><epage>1404</epage><pages>1402-1404</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15111682</pmid><doi>10.1212/01.WNL.0000123694.64121.D5</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neurology, 2004-04, Vol.62 (8), p.1402-1404 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - immunology Adenocarcinoma - secondary Adult Biological and medical sciences Carcinoembryonic Antigen - blood Deglutition Disorders - etiology Dysarthria - etiology Female Fluorodeoxyglucose F18 Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - immunology Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - immunology Medical sciences Muscle Weakness - etiology Muscle Weakness - physiopathology Neurology Neurons - immunology Palliative Care Paraneoplastic Syndromes, Nervous System - diagnosis Paraneoplastic Syndromes, Nervous System - immunology Radionuclide Imaging Spinal Cord - immunology Stiff-Person Syndrome - diagnosis Stiff-Person Syndrome - immunology Upper Extremity - physiopathology |
| title | Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies |
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