Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies

A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with...

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Veröffentlicht in:	Neurology 2004-04, Vol.62 (8), p.1402-1404
Hauptverfasser:	MCCABE, D. J. H, TURNER, N. C, CHAO, D, LEFF, A, GREGSON, N. A, WOMERSLEY, H. J, MAK, I, PERKIN, G. D, SCHAPIRA, A. H. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnostic imaging Adenocarcinoma - immunology Adenocarcinoma - secondary Adult Biological and medical sciences Carcinoembryonic Antigen - blood Deglutition Disorders - etiology Dysarthria - etiology Female Fluorodeoxyglucose F18 Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - immunology Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - immunology Medical sciences Muscle Weakness - etiology Muscle Weakness - physiopathology Neurology Neurons - immunology Palliative Care Paraneoplastic Syndromes, Nervous System - diagnosis Paraneoplastic Syndromes, Nervous System - immunology Radionuclide Imaging Spinal Cord - immunology Stiff-Person Syndrome - diagnosis Stiff-Person Syndrome - immunology Upper Extremity - physiopathology
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Beschreibung
Zusammenfassung:	A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000123694.64121.D5