Control of the Vascular Endothelial Growth Factor Internal Ribosome Entry Site (IRES) Activity and Translation Initiation by Alternatively Spliced Coding Sequences

The vascular endothelial growth factor-A ( VEGF ) gene locus contains eight exons that span 14 kb. Alternative splicing generates multiple, different mRNAs that in turn translate into at least five protein isoforms. While the canonical AUG start codon is located at position 1039 in exon 1, there als...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (18), p.18717-18726
Hauptverfasser:	Bornes, Stéphanie, Boulard, Mathieu, Hieblot, Corinne, Zanibellato, Catherine, Iacovoni, Jason S, Prats, Hervé, Touriol, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Alternative Splicing - genetics Base Sequence Codon, Initiator - genetics Exons HeLa Cells Humans Molecular Sequence Data Peptide Chain Initiation, Translational Protein Biosynthesis Ribosomes - genetics RNA, Messenger Vascular Endothelial Growth Factor A - genetics
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