Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans
Oxygen metabolites generated bymyeloperoxidase (MPO) and nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase contribute to microbial killing by phagocytes. To compare the importance of the 2 enzymes for host defense, MPO-deficient (MPO−/−) mice and NADPH-oxidase-deficient mice with chronic g...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-06, Vol.185 (12), p.1833-1837 |
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| container_title | The Journal of infectious diseases |
| container_volume | 185 |
| creator | Aratani, Yasuaki Kura, Fumiaki Watanabe, Haruo Akagawa, Hisayoshi Takano, Yukie Suzuki, Kazuo Dinauer, Mary C. Maeda, Nobuyo Koyama, Hideki |
| description | Oxygen metabolites generated bymyeloperoxidase (MPO) and nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase contribute to microbial killing by phagocytes. To compare the importance of the 2 enzymes for host defense, MPO-deficient (MPO−/−) mice and NADPH-oxidase-deficient mice with chronic granulomatous disease (CGD mice) were intraperitoneally infected with 3 different doses of Candida albicans, and their infection severity was analyzed. CGD mice had increased mortality and exhibited increased tissue fungal burden in a dose-dependent manner, whereas normal mice showed no symptoms. Of interest, at the highest dose, the mortality of MPO−/− mice was comparable to that of CGD mice, but at the lowest dose, it was the same as that of normal mice. At the middle dose, the number of fungi disseminated into various organs of the MPO−/− mice was comparable to that of the CGD mice at day 6 of infection, but it was significantly lower at day 14. These results suggest that MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida. |
| doi_str_mv | 10.1086/340635 |
| format | Article |
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To compare the importance of the 2 enzymes for host defense, MPO-deficient (MPO−/−) mice and NADPH-oxidase-deficient mice with chronic granulomatous disease (CGD mice) were intraperitoneally infected with 3 different doses of Candida albicans, and their infection severity was analyzed. CGD mice had increased mortality and exhibited increased tissue fungal burden in a dose-dependent manner, whereas normal mice showed no symptoms. Of interest, at the highest dose, the mortality of MPO−/− mice was comparable to that of CGD mice, but at the lowest dose, it was the same as that of normal mice. At the middle dose, the number of fungi disseminated into various organs of the MPO−/− mice was comparable to that of the CGD mice at day 6 of infection, but it was significantly lower at day 14. These results suggest that MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/340635</identifier><identifier>PMID: 12085336</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Biological and medical sciences ; Candida albicans ; Candidiasis - physiopathology ; Chronic granulomatous disease ; Concise Comunications ; Disease Susceptibility ; Dosage ; Female ; Fundamental and applied biological sciences. 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To compare the importance of the 2 enzymes for host defense, MPO-deficient (MPO−/−) mice and NADPH-oxidase-deficient mice with chronic granulomatous disease (CGD mice) were intraperitoneally infected with 3 different doses of Candida albicans, and their infection severity was analyzed. CGD mice had increased mortality and exhibited increased tissue fungal burden in a dose-dependent manner, whereas normal mice showed no symptoms. Of interest, at the highest dose, the mortality of MPO−/− mice was comparable to that of CGD mice, but at the lowest dose, it was the same as that of normal mice. At the middle dose, the number of fungi disseminated into various organs of the MPO−/− mice was comparable to that of the CGD mice at day 6 of infection, but it was significantly lower at day 14. These results suggest that MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Candidiasis - physiopathology</subject><subject>Chronic granulomatous disease</subject><subject>Concise Comunications</subject><subject>Disease Susceptibility</subject><subject>Dosage</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungi</subject><subject>Granulomatous Disease, Chronic - immunology</subject><subject>Infections</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Microbiology</subject><subject>Mortality</subject><subject>Mycology</subject><subject>NADPH Oxidases - physiology</subject><subject>Neutrophils</subject><subject>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</subject><subject>Peroxidase - physiology</subject><subject>Phagocytes</subject><subject>Phagocytes - immunology</subject><subject>Research universities</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1u1DAQhSMEotsCbwAyleAu4L_YziVaAYuoxE2Rqt5YjjNhvSR2aiei-yY8Li5ZuhIS4srSzDfnzPgUxTOC3xCsxFvGsWDVg2JFKiZLIQh7WKwwprQkqq5PitOUdhhjzoR8XJwQilXFmFgVP9fRTc6aHsXQAwodGvbQhxFiuHWtSYCMb5F3NkzOm8G1udCCdx5Q6_xse8iNXBy3IY1bM0H5Z855tHXftmUzxzyA0j5NMDib6x3YyQX_28xZQD_ctEXr7JMHkembvI5PT4pHnekTPD28Z8XXD-8v15vy4svHT-t3F6XlvJ5KaFRllOA236Zwh4G3Rkhe2VpWHBPWNJwCE9haShVueWOZJQ3DmMmOQ1Wxs-L1ojvGcDNDmvTgkoW-Nx7CnLQkWZ1y_F-QKC6UrEkGz_8Cd2GOPh-hKWV1zkSQo5qNIaUInR6jG0zca4L1XaJ6STSDLw5qczNAe8QOEWbg1QEwKefYReOtS0eOSaYY5Zl7uXBhHv9t9nxhdmkK8Z5i-SMVqe-8yqXvcpi3930Tv2shmaz05upaX9PLz3Ijqb5ivwCbG8u7</recordid><startdate>20020615</startdate><enddate>20020615</enddate><creator>Aratani, Yasuaki</creator><creator>Kura, Fumiaki</creator><creator>Watanabe, Haruo</creator><creator>Akagawa, Hisayoshi</creator><creator>Takano, Yukie</creator><creator>Suzuki, Kazuo</creator><creator>Dinauer, Mary C.</creator><creator>Maeda, Nobuyo</creator><creator>Koyama, Hideki</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20020615</creationdate><title>Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans</title><author>Aratani, Yasuaki ; Kura, Fumiaki ; Watanabe, Haruo ; Akagawa, Hisayoshi ; Takano, Yukie ; Suzuki, Kazuo ; Dinauer, Mary C. ; Maeda, Nobuyo ; Koyama, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-eb85a864c00480f0e4da6745c9754013bb42e360cc2280d4bc3c1b30037f4e553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Candidiasis - physiopathology</topic><topic>Chronic granulomatous disease</topic><topic>Concise Comunications</topic><topic>Disease Susceptibility</topic><topic>Dosage</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungi</topic><topic>Granulomatous Disease, Chronic - immunology</topic><topic>Infections</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Microbiology</topic><topic>Mortality</topic><topic>Mycology</topic><topic>NADPH Oxidases - physiology</topic><topic>Neutrophils</topic><topic>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</topic><topic>Peroxidase - physiology</topic><topic>Phagocytes</topic><topic>Phagocytes - immunology</topic><topic>Research universities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aratani, Yasuaki</creatorcontrib><creatorcontrib>Kura, Fumiaki</creatorcontrib><creatorcontrib>Watanabe, Haruo</creatorcontrib><creatorcontrib>Akagawa, Hisayoshi</creatorcontrib><creatorcontrib>Takano, Yukie</creatorcontrib><creatorcontrib>Suzuki, Kazuo</creatorcontrib><creatorcontrib>Dinauer, Mary C.</creatorcontrib><creatorcontrib>Maeda, Nobuyo</creatorcontrib><creatorcontrib>Koyama, Hideki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aratani, Yasuaki</au><au>Kura, Fumiaki</au><au>Watanabe, Haruo</au><au>Akagawa, Hisayoshi</au><au>Takano, Yukie</au><au>Suzuki, Kazuo</au><au>Dinauer, Mary C.</au><au>Maeda, Nobuyo</au><au>Koyama, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-06-15</date><risdate>2002</risdate><volume>185</volume><issue>12</issue><spage>1833</spage><epage>1837</epage><pages>1833-1837</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Oxygen metabolites generated bymyeloperoxidase (MPO) and nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase contribute to microbial killing by phagocytes. To compare the importance of the 2 enzymes for host defense, MPO-deficient (MPO−/−) mice and NADPH-oxidase-deficient mice with chronic granulomatous disease (CGD mice) were intraperitoneally infected with 3 different doses of Candida albicans, and their infection severity was analyzed. CGD mice had increased mortality and exhibited increased tissue fungal burden in a dose-dependent manner, whereas normal mice showed no symptoms. Of interest, at the highest dose, the mortality of MPO−/− mice was comparable to that of CGD mice, but at the lowest dose, it was the same as that of normal mice. At the middle dose, the number of fungi disseminated into various organs of the MPO−/− mice was comparable to that of the CGD mice at day 6 of infection, but it was significantly lower at day 14. These results suggest that MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12085336</pmid><doi>10.1086/340635</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Candida albicans Candidiasis - physiopathology Chronic granulomatous disease Concise Comunications Disease Susceptibility Dosage Female Fundamental and applied biological sciences. Psychology Fungi Granulomatous Disease, Chronic - immunology Infections Mice Mice, Inbred C57BL Mice, Knockout Microbiology Mortality Mycology NADPH Oxidases - physiology Neutrophils Pathogenicity, host-agent relations, miscellaneous strains, epidemiology Peroxidase - physiology Phagocytes Phagocytes - immunology Research universities |
| title | Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans |
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