A potential role for the nucleolus in L1 retrotransposition

Determining the subcellular localization of the L1 ORF2 protein (ORF2p) has been impossible to date because of technical limitations in detecting either endogenous or overexpressed forms of the protein. Here we report visualization of the full-length ORF2p in cultured human cells following expressio...

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Veröffentlicht in:	Human molecular genetics 2004-05, Vol.13 (10), p.1041-1048
Hauptverfasser:	Goodier, John L., Ostertag, Eric M., Engleka, Kurt A., Seleme, Maria C., Kazazian, Haig H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Culture Techniques Cell Nucleolus - chemistry Cell Nucleolus - ultrastructure Classical genetics, quantitative genetics, hybrids Cloning, Molecular Cytoplasm - ultrastructure DNA Transposable Elements DNA-Directed RNA Polymerases - genetics Endonucleases - analysis Endonucleases - genetics Endonucleases - metabolism Endothelial Cells - ultrastructure Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Green Fluorescent Proteins - analysis Green Fluorescent Proteins - genetics Human Humans Immunochemistry Long Interspersed Nucleotide Elements - genetics Molecular and cellular biology Nuclear Localization Signals - genetics Ribonucleoproteins - analysis Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA-Directed DNA Polymerase - analysis RNA-Directed DNA Polymerase - genetics RNA-Directed DNA Polymerase - metabolism Umbilical Veins - cytology Viral Proteins
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