Hypoxia of sleep apnoea: cardiopulmonary and cerebral changes after intermittent hypoxia in rats

Sleep apnoea (SA) is common, especially in elderly people. In severe cases, arterial P O 2 may be lowered for a third or more in a night of sleep. To simulate the degree and duration of severe SA we exposed rats in a normobaric environmental chamber to 10% O 2 for 4 h daily for 56 days (intermittent...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2004-04, Vol.140 (1), p.53-62
Hauptverfasser:	Kalaria, Raj N., Spoors, Louise, Laude, Elizabeth A., Emery, Celia J., Thwaites-Bee, Denise, Fairlie, John, Oakley, Arthur E., Barer, David H., Barer, Gwenda R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Biological and medical sciences Blood Pressure - physiology Cardiorespiratory control. Arterial mecano- and chemoreceptor Cerebral Cortex - blood supply Cerebral Cortex - metabolism Disease Models, Animal Endothelium, Vascular - pathology Fundamental and applied biological sciences. Psychology Glucose Transporter Type 1 Heart, hypertrophy Hypertrophy - etiology Hypertrophy, Right Ventricular - etiology Hypertrophy, Right Ventricular - pathology Hypoxia - complications Hypoxia - metabolism Hypoxia - pathology Hypoxia, intermittent vs. continuous Immunohistochemistry Lung - blood supply Lung - pathology Mammals, rat Mediators, VEGF Monosaccharide Transport Proteins - metabolism Pulmonary circulation, hypoxia Rats Rats, Wistar Sleep Apnea Syndromes - complications Sleep Apnea Syndromes - metabolism Sleep Apnea Syndromes - pathology Sleep, aponea Transporter, GLUT1 Vascular Endothelial Growth Factor A - metabolism Vertebrates: respiratory system Vessels, angiogenesis, hypoxia
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