Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants
Mood sensitivity to rapid tryptophan depletion (RTD) has been demonstrated in patients treated with antidepressants that act preferentially on the serotonergic system. Depressed patients treated with bright-light therapy also show sensitivity to RTD, but those treated with electroconvulsive therapy...
Gespeichert in:
| Veröffentlicht in: | Biological psychiatry (1969) 2004-05, Vol.55 (9), p.957-959 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 959 |
|---|---|
| container_issue | 9 |
| container_start_page | 957 |
| container_title | Biological psychiatry (1969) |
| container_volume | 55 |
| creator | O'Reardon, John P Chopra, Mohit P Bergan, Alexandra Gallop, Robert DeRubeis, Robert J Crits-Christoph, Paul |
| description | Mood sensitivity to rapid tryptophan depletion (RTD) has been demonstrated in patients treated with antidepressants that act preferentially on the serotonergic system. Depressed patients treated with bright-light therapy also show sensitivity to RTD, but those treated with electroconvulsive therapy or total sleep deprivation do not. Patients treated with an empirically supported psychotherapy have not been investigated for sensitivity to tryptophan depletion. This study compares the effects of RTD in patients treated with either selective serotonin re-uptake inhibitors (SSRIs) or cognitive therapy (CT).
Twenty patients treated with either SSRIs or CT underwent both rapid tryptophan depletion and sham-depletion using a blinded crossover design. Depressive symptoms were assessed using a modified Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI). The differential change in depression scores across procedures between the groups was compared, and effect sizes were calculated.
The differential worsening of mood for the SSRI group compared with the CT group was significant on the BDI. The effect size of the differential change was 1.6 for the BDI and .8 for the HDRS. Furthermore, the SSRI group experienced significant mood worsening during depletion compared with sham on both the HDRS and the BDI, whereas the CT group did not.
The CT group was resistant to the effects of tryptophan depletion, but the SSRI group was not. |
| doi_str_mv | 10.1016/j.biopsych.2003.12.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71861190</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006322304000605</els_id><sourcerecordid>71861190</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-2c9dcfb7ee42054087fdb469d027414a9ec854f90687fa40ca8c4b063e70756b3</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxi1ERZfCK1S-wC1h7Dj_bqCKFqRKSBWcLceZsF6ydvB4i_Y9eGC8bBDcuNie8W--sedj7FpAKUA0b3bl4MJCR7stJUBVClmChCdsI7q2KqQC-ZRtAKApKimrS_acaJfDVkrxjF2KWgholdiwnw9IS_CEPAWe4nFJYdkaz0dcZkwueO4835tdiKdURKJTLkU0CUf-w6Utx7xg5DZ89S65x6yUQ7Mcea4hnNH-ThLGkILPahEPSzLfMCtv3eBSxoxPbpXPR3rBLiYzE75c9yv25fb955sPxf2nu4837-4LW_UqFdL2o52GFlFJqBV07TQOqulHkPlvyvRou1pNPTT5xiiwprNqgKbCFtq6Gaor9vqsu8Tw_YCU9N6RxXk2HsOBdCu6RogeMticQRsDUcRJL9HtTTxqAfrkh97pP37okx9aSJ39yIXXa4fDsMfxb9lqQAZerYAha-YpGm8d_cO1sq6FytzbM4d5Ho8Ooybr0FscXcwT1mNw_3vLL5U2sYs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71861190</pqid></control><display><type>article</type><title>Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>O'Reardon, John P ; Chopra, Mohit P ; Bergan, Alexandra ; Gallop, Robert ; DeRubeis, Robert J ; Crits-Christoph, Paul</creator><creatorcontrib>O'Reardon, John P ; Chopra, Mohit P ; Bergan, Alexandra ; Gallop, Robert ; DeRubeis, Robert J ; Crits-Christoph, Paul</creatorcontrib><description>Mood sensitivity to rapid tryptophan depletion (RTD) has been demonstrated in patients treated with antidepressants that act preferentially on the serotonergic system. Depressed patients treated with bright-light therapy also show sensitivity to RTD, but those treated with electroconvulsive therapy or total sleep deprivation do not. Patients treated with an empirically supported psychotherapy have not been investigated for sensitivity to tryptophan depletion. This study compares the effects of RTD in patients treated with either selective serotonin re-uptake inhibitors (SSRIs) or cognitive therapy (CT).
Twenty patients treated with either SSRIs or CT underwent both rapid tryptophan depletion and sham-depletion using a blinded crossover design. Depressive symptoms were assessed using a modified Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI). The differential change in depression scores across procedures between the groups was compared, and effect sizes were calculated.
The differential worsening of mood for the SSRI group compared with the CT group was significant on the BDI. The effect size of the differential change was 1.6 for the BDI and .8 for the HDRS. Furthermore, the SSRI group experienced significant mood worsening during depletion compared with sham on both the HDRS and the BDI, whereas the CT group did not.
The CT group was resistant to the effects of tryptophan depletion, but the SSRI group was not.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2003.12.020</identifier><identifier>PMID: 15110741</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Behavior therapy. Cognitive therapy ; Biological and medical sciences ; Cognitive therapy ; Cognitive Therapy - methods ; Cross-Over Studies ; Depression ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - metabolism ; Depressive Disorder, Major - therapy ; Diagnostic and Statistical Manual of Mental Disorders ; Double-Blind Method ; Drug Administration Schedule ; Female ; Fluoxetine - administration & dosage ; Fluoxetine - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Paroxetine - administration & dosage ; Paroxetine - therapeutic use ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Remission Induction ; serotonin ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - therapeutic use ; Severity of Illness Index ; Treatments ; Tryptophan - blood ; Tryptophan - deficiency ; tryptophan depletion</subject><ispartof>Biological psychiatry (1969), 2004-05, Vol.55 (9), p.957-959</ispartof><rights>2004 Society of Biological Psychiatry</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-2c9dcfb7ee42054087fdb469d027414a9ec854f90687fa40ca8c4b063e70756b3</citedby><cites>FETCH-LOGICAL-c394t-2c9dcfb7ee42054087fdb469d027414a9ec854f90687fa40ca8c4b063e70756b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsych.2003.12.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15725514$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15110741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Reardon, John P</creatorcontrib><creatorcontrib>Chopra, Mohit P</creatorcontrib><creatorcontrib>Bergan, Alexandra</creatorcontrib><creatorcontrib>Gallop, Robert</creatorcontrib><creatorcontrib>DeRubeis, Robert J</creatorcontrib><creatorcontrib>Crits-Christoph, Paul</creatorcontrib><title>Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Mood sensitivity to rapid tryptophan depletion (RTD) has been demonstrated in patients treated with antidepressants that act preferentially on the serotonergic system. Depressed patients treated with bright-light therapy also show sensitivity to RTD, but those treated with electroconvulsive therapy or total sleep deprivation do not. Patients treated with an empirically supported psychotherapy have not been investigated for sensitivity to tryptophan depletion. This study compares the effects of RTD in patients treated with either selective serotonin re-uptake inhibitors (SSRIs) or cognitive therapy (CT).
Twenty patients treated with either SSRIs or CT underwent both rapid tryptophan depletion and sham-depletion using a blinded crossover design. Depressive symptoms were assessed using a modified Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI). The differential change in depression scores across procedures between the groups was compared, and effect sizes were calculated.
The differential worsening of mood for the SSRI group compared with the CT group was significant on the BDI. The effect size of the differential change was 1.6 for the BDI and .8 for the HDRS. Furthermore, the SSRI group experienced significant mood worsening during depletion compared with sham on both the HDRS and the BDI, whereas the CT group did not.
The CT group was resistant to the effects of tryptophan depletion, but the SSRI group was not.</description><subject>Adult and adolescent clinical studies</subject><subject>Behavior therapy. Cognitive therapy</subject><subject>Biological and medical sciences</subject><subject>Cognitive therapy</subject><subject>Cognitive Therapy - methods</subject><subject>Cross-Over Studies</subject><subject>Depression</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - metabolism</subject><subject>Depressive Disorder, Major - therapy</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fluoxetine - administration & dosage</subject><subject>Fluoxetine - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Paroxetine - administration & dosage</subject><subject>Paroxetine - therapeutic use</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Remission Induction</subject><subject>serotonin</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Severity of Illness Index</subject><subject>Treatments</subject><subject>Tryptophan - blood</subject><subject>Tryptophan - deficiency</subject><subject>tryptophan depletion</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1ERZfCK1S-wC1h7Dj_bqCKFqRKSBWcLceZsF6ydvB4i_Y9eGC8bBDcuNie8W--sedj7FpAKUA0b3bl4MJCR7stJUBVClmChCdsI7q2KqQC-ZRtAKApKimrS_acaJfDVkrxjF2KWgholdiwnw9IS_CEPAWe4nFJYdkaz0dcZkwueO4835tdiKdURKJTLkU0CUf-w6Utx7xg5DZ89S65x6yUQ7Mcea4hnNH-ThLGkILPahEPSzLfMCtv3eBSxoxPbpXPR3rBLiYzE75c9yv25fb955sPxf2nu4837-4LW_UqFdL2o52GFlFJqBV07TQOqulHkPlvyvRou1pNPTT5xiiwprNqgKbCFtq6Gaor9vqsu8Tw_YCU9N6RxXk2HsOBdCu6RogeMticQRsDUcRJL9HtTTxqAfrkh97pP37okx9aSJ39yIXXa4fDsMfxb9lqQAZerYAha-YpGm8d_cO1sq6FytzbM4d5Ho8Ooybr0FscXcwT1mNw_3vLL5U2sYs</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>O'Reardon, John P</creator><creator>Chopra, Mohit P</creator><creator>Bergan, Alexandra</creator><creator>Gallop, Robert</creator><creator>DeRubeis, Robert J</creator><creator>Crits-Christoph, Paul</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants</title><author>O'Reardon, John P ; Chopra, Mohit P ; Bergan, Alexandra ; Gallop, Robert ; DeRubeis, Robert J ; Crits-Christoph, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-2c9dcfb7ee42054087fdb469d027414a9ec854f90687fa40ca8c4b063e70756b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Behavior therapy. Cognitive therapy</topic><topic>Biological and medical sciences</topic><topic>Cognitive therapy</topic><topic>Cognitive Therapy - methods</topic><topic>Cross-Over Studies</topic><topic>Depression</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - metabolism</topic><topic>Depressive Disorder, Major - therapy</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fluoxetine - administration & dosage</topic><topic>Fluoxetine - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Paroxetine - administration & dosage</topic><topic>Paroxetine - therapeutic use</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Remission Induction</topic><topic>serotonin</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Severity of Illness Index</topic><topic>Treatments</topic><topic>Tryptophan - blood</topic><topic>Tryptophan - deficiency</topic><topic>tryptophan depletion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Reardon, John P</creatorcontrib><creatorcontrib>Chopra, Mohit P</creatorcontrib><creatorcontrib>Bergan, Alexandra</creatorcontrib><creatorcontrib>Gallop, Robert</creatorcontrib><creatorcontrib>DeRubeis, Robert J</creatorcontrib><creatorcontrib>Crits-Christoph, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Reardon, John P</au><au>Chopra, Mohit P</au><au>Bergan, Alexandra</au><au>Gallop, Robert</au><au>DeRubeis, Robert J</au><au>Crits-Christoph, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>55</volume><issue>9</issue><spage>957</spage><epage>959</epage><pages>957-959</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Mood sensitivity to rapid tryptophan depletion (RTD) has been demonstrated in patients treated with antidepressants that act preferentially on the serotonergic system. Depressed patients treated with bright-light therapy also show sensitivity to RTD, but those treated with electroconvulsive therapy or total sleep deprivation do not. Patients treated with an empirically supported psychotherapy have not been investigated for sensitivity to tryptophan depletion. This study compares the effects of RTD in patients treated with either selective serotonin re-uptake inhibitors (SSRIs) or cognitive therapy (CT).
Twenty patients treated with either SSRIs or CT underwent both rapid tryptophan depletion and sham-depletion using a blinded crossover design. Depressive symptoms were assessed using a modified Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI). The differential change in depression scores across procedures between the groups was compared, and effect sizes were calculated.
The differential worsening of mood for the SSRI group compared with the CT group was significant on the BDI. The effect size of the differential change was 1.6 for the BDI and .8 for the HDRS. Furthermore, the SSRI group experienced significant mood worsening during depletion compared with sham on both the HDRS and the BDI, whereas the CT group did not.
The CT group was resistant to the effects of tryptophan depletion, but the SSRI group was not.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15110741</pmid><doi>10.1016/j.biopsych.2003.12.020</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 2004-05, Vol.55 (9), p.957-959 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71861190 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult and adolescent clinical studies Behavior therapy. Cognitive therapy Biological and medical sciences Cognitive therapy Cognitive Therapy - methods Cross-Over Studies Depression Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Depressive Disorder, Major - therapy Diagnostic and Statistical Manual of Mental Disorders Double-Blind Method Drug Administration Schedule Female Fluoxetine - administration & dosage Fluoxetine - therapeutic use Humans Male Medical sciences Middle Aged Mood disorders Paroxetine - administration & dosage Paroxetine - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Remission Induction serotonin Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - therapeutic use Severity of Illness Index Treatments Tryptophan - blood Tryptophan - deficiency tryptophan depletion |
| title | Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T20%3A09%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Response%20to%20tryptophan%20depletion%20in%20major%20depression%20treated%20with%20either%20cognitive%20therapy%20or%20selective%20serotonin%20reuptake%20inhibitor%20antidepressants&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=O'Reardon,%20John%20P&rft.date=2004-05-01&rft.volume=55&rft.issue=9&rft.spage=957&rft.epage=959&rft.pages=957-959&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/j.biopsych.2003.12.020&rft_dat=%3Cproquest_cross%3E71861190%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71861190&rft_id=info:pmid/15110741&rft_els_id=S0006322304000605&rfr_iscdi=true |