Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4

A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connect...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (10), p.2653-2656
Hauptverfasser:	ROCCO, Vincent P, SPINAZZE, Patrick G, TAKEUCHI, Kumiko, KOHN, Todd J, HONIGSCHMIDT, Nicholas A, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressive Agents, Second-Generation - chemical synthesis Antidepressive Agents, Second-Generation - pharmacology Biological and medical sciences Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - pharmacology Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Propanols - chemical synthesis Propanols - pharmacology Protein Binding Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serotonin 5-HT1 Receptor Antagonists Serotonin Uptake Inhibitors - chemical synthesis Serotonin Uptake Inhibitors - pharmacology Serotoninergic system Stereoisomerism Structure-Activity Relationship
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