Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study

Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). S...

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Veröffentlicht in:Journal of allergy and clinical immunology 2004-03, Vol.113 (3), p.489-495
Hauptverfasser: Liu, Xin, Beaty, Terri H, Deindl, Philipp, Huang, Shau-Ku, Lau, Susanne, Sommerfeld, Christine, Fallin, M.Daniele, Kao, W.H.Linda, Wahn, Ulrich, Nickel, Renate
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container_title Journal of allergy and clinical immunology
container_volume 113
creator Liu, Xin
Beaty, Terri H
Deindl, Philipp
Huang, Shau-Ku
Lau, Susanne
Sommerfeld, Christine
Fallin, M.Daniele
Kao, W.H.Linda
Wahn, Ulrich
Nickel, Renate
description Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors. We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated. Multiple logistic regression models were used for the analyses of 4 sensitization outcomes. The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples. These findings not only suggested that variants in the IL4, IL13, and IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.
doi_str_mv 10.1016/j.jaci.2003.12.037
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SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors. We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated. Multiple logistic regression models were used for the analyses of 4 sensitization outcomes. The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples. 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SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors. We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated. Multiple logistic regression models were used for the analyses of 4 sensitization outcomes. The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. 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Psychology</subject><subject>Fundamental immunology</subject><subject>Genes</subject><subject>Genetic Variation</subject><subject>Germany</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - genetics</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>IL13</subject><subject>IL4</subject><subject>IL4RA</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Interleukin-13 - genetics</subject><subject>Interleukin-4 - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mites - immunology</subject><subject>Receptors, Interleukin-4 - genetics</subject><subject>Sensitization</subject><subject>single nucleotide polymorphism</subject><subject>Smoking</subject><subject>Studies</subject><subject>Tobacco smoke</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0t2K1DAUAOAgijuuvoAXEhC92tb8NE0j3gzLug6MCLpehzQ9s5PSpt0k3WUexnc1444g3iScnC9_h4PQa0pKSmj9oS97Y13JCOElZSXh8glaUaJkUTdMPEUrQhQtalmpM_Qixp7kmDfqOTqjghDJBVuhX-sYJ-tMcpOPuIX0AOBxnMG6nbM4QlhGvLm9wgHinAlg4ztc43sTnPEp4geX9s7jtAd8Cx4i3myrizxQfvGH5vD7GmdxDWE0Htu9G7qQ7_iIb_Ke0-rXZUjOgk8Q8DpN8wH_SEt3eIme7cwQ4dVpPkc_P1_dXH4ptt-uN5frbQGckVSYqpVG1iAJa1XLhGiqRkGtVMfbnCFUtCAssRI6IXgHVWXbhrOc4U3LTcXP0fvHc-cw3S0Qkx5dtDAMxsO0RC1pU1PCVIZv_4P9tASf36ZzTauGK1aRrN6c1NKO0Ok5uNGEg_5b9gzenYCJ1gy7YLx18R8nJJW1yO7To4P8-XsHQUfrwFvoXACbdDc5TYk-doPu9bEb9LEbNGU6dwP_DUO7pVQ</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Liu, Xin</creator><creator>Beaty, Terri H</creator><creator>Deindl, Philipp</creator><creator>Huang, Shau-Ku</creator><creator>Lau, Susanne</creator><creator>Sommerfeld, Christine</creator><creator>Fallin, M.Daniele</creator><creator>Kao, W.H.Linda</creator><creator>Wahn, Ulrich</creator><creator>Nickel, Renate</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study</title><author>Liu, Xin ; Beaty, Terri H ; Deindl, Philipp ; Huang, Shau-Ku ; Lau, Susanne ; Sommerfeld, Christine ; Fallin, M.Daniele ; Kao, W.H.Linda ; Wahn, Ulrich ; Nickel, Renate</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e320t-a4b7a76e702b9b2558489e699d3bb7a015be5c0c7ed553de44cb8327a038b3a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age</topic><topic>Allergens</topic><topic>Allergies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cats</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Food</topic><topic>Food Hypersensitivity - genetics</topic><topic>Food Hypersensitivity - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes</topic><topic>Genetic Variation</topic><topic>Germany</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - genetics</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>IL13</topic><topic>IL4</topic><topic>IL4RA</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Interleukin-13 - genetics</topic><topic>Interleukin-4 - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mites - immunology</topic><topic>Receptors, Interleukin-4 - genetics</topic><topic>Sensitization</topic><topic>single nucleotide polymorphism</topic><topic>Smoking</topic><topic>Studies</topic><topic>Tobacco smoke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Beaty, Terri H</creatorcontrib><creatorcontrib>Deindl, Philipp</creatorcontrib><creatorcontrib>Huang, Shau-Ku</creatorcontrib><creatorcontrib>Lau, Susanne</creatorcontrib><creatorcontrib>Sommerfeld, Christine</creatorcontrib><creatorcontrib>Fallin, M.Daniele</creatorcontrib><creatorcontrib>Kao, W.H.Linda</creatorcontrib><creatorcontrib>Wahn, Ulrich</creatorcontrib><creatorcontrib>Nickel, Renate</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xin</au><au>Beaty, Terri H</au><au>Deindl, Philipp</au><au>Huang, Shau-Ku</au><au>Lau, Susanne</au><au>Sommerfeld, Christine</au><au>Fallin, M.Daniele</au><au>Kao, W.H.Linda</au><au>Wahn, Ulrich</au><au>Nickel, Renate</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>113</volume><issue>3</issue><spage>489</spage><epage>495</epage><pages>489-495</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors. We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated. Multiple logistic regression models were used for the analyses of 4 sensitization outcomes. The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples. These findings not only suggested that variants in the IL4, IL13, and IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15007352</pmid><doi>10.1016/j.jaci.2003.12.037</doi><tpages>7</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Age
Allergens
Allergies
Animals
Biological and medical sciences
Case-Control Studies
Cats
Child
Child, Preschool
Female
Food
Food Hypersensitivity - genetics
Food Hypersensitivity - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Genetic Variation
Germany
Haplotypes
Humans
Hypersensitivity, Immediate - genetics
Hypersensitivity, Immediate - immunology
IL13
IL4
IL4RA
Immunoglobulin E - blood
Immunopathology
Infant
Interleukin-13 - genetics
Interleukin-4 - genetics
Male
Medical sciences
Mites - immunology
Receptors, Interleukin-4 - genetics
Sensitization
single nucleotide polymorphism
Smoking
Studies
Tobacco smoke
title Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study
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