Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study
Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). S...
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creator | Liu, Xin Beaty, Terri H Deindl, Philipp Huang, Shau-Ku Lau, Susanne Sommerfeld, Christine Fallin, M.Daniele Kao, W.H.Linda Wahn, Ulrich Nickel, Renate |
description | Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the
IL4 gene, C-1055T and Arg130Gln in the
IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the
IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.
We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.
Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.
The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the
IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.
These findings not only suggested that variants in the
IL4,
IL13, and
IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population. |
doi_str_mv | 10.1016/j.jaci.2003.12.037 |
format | Article |
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IL4 gene, C-1055T and Arg130Gln in the
IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the
IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.
We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.
Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.
The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the
IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.
These findings not only suggested that variants in the
IL4,
IL13, and
IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2003.12.037</identifier><identifier>PMID: 15007352</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Age ; Allergens ; Allergies ; Animals ; Biological and medical sciences ; Case-Control Studies ; Cats ; Child ; Child, Preschool ; Female ; Food ; Food Hypersensitivity - genetics ; Food Hypersensitivity - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genes ; Genetic Variation ; Germany ; Haplotypes ; Humans ; Hypersensitivity, Immediate - genetics ; Hypersensitivity, Immediate - immunology ; IL13 ; IL4 ; IL4RA ; Immunoglobulin E - blood ; Immunopathology ; Infant ; Interleukin-13 - genetics ; Interleukin-4 - genetics ; Male ; Medical sciences ; Mites - immunology ; Receptors, Interleukin-4 - genetics ; Sensitization ; single nucleotide polymorphism ; Smoking ; Studies ; Tobacco smoke</subject><ispartof>Journal of allergy and clinical immunology, 2004-03, Vol.113 (3), p.489-495</ispartof><rights>2004 American Academy of Allergy, Asthma and Immunology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Mar 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2003.12.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15571765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15007352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Beaty, Terri H</creatorcontrib><creatorcontrib>Deindl, Philipp</creatorcontrib><creatorcontrib>Huang, Shau-Ku</creatorcontrib><creatorcontrib>Lau, Susanne</creatorcontrib><creatorcontrib>Sommerfeld, Christine</creatorcontrib><creatorcontrib>Fallin, M.Daniele</creatorcontrib><creatorcontrib>Kao, W.H.Linda</creatorcontrib><creatorcontrib>Wahn, Ulrich</creatorcontrib><creatorcontrib>Nickel, Renate</creatorcontrib><title>Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the
IL4 gene, C-1055T and Arg130Gln in the
IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the
IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.
We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.
Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.
The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the
IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.
These findings not only suggested that variants in the
IL4,
IL13, and
IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.</description><subject>Age</subject><subject>Allergens</subject><subject>Allergies</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cats</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Food</subject><subject>Food Hypersensitivity - genetics</subject><subject>Food Hypersensitivity - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes</subject><subject>Genetic Variation</subject><subject>Germany</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - genetics</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>IL13</subject><subject>IL4</subject><subject>IL4RA</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Interleukin-13 - genetics</subject><subject>Interleukin-4 - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mites - immunology</subject><subject>Receptors, Interleukin-4 - genetics</subject><subject>Sensitization</subject><subject>single nucleotide polymorphism</subject><subject>Smoking</subject><subject>Studies</subject><subject>Tobacco smoke</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0t2K1DAUAOAgijuuvoAXEhC92tb8NE0j3gzLug6MCLpehzQ9s5PSpt0k3WUexnc1444g3iScnC9_h4PQa0pKSmj9oS97Y13JCOElZSXh8glaUaJkUTdMPEUrQhQtalmpM_Qixp7kmDfqOTqjghDJBVuhX-sYJ-tMcpOPuIX0AOBxnMG6nbM4QlhGvLm9wgHinAlg4ztc43sTnPEp4geX9s7jtAd8Cx4i3myrizxQfvGH5vD7GmdxDWE0Htu9G7qQ7_iIb_Ke0-rXZUjOgk8Q8DpN8wH_SEt3eIme7cwQ4dVpPkc_P1_dXH4ptt-uN5frbQGckVSYqpVG1iAJa1XLhGiqRkGtVMfbnCFUtCAssRI6IXgHVWXbhrOc4U3LTcXP0fvHc-cw3S0Qkx5dtDAMxsO0RC1pU1PCVIZv_4P9tASf36ZzTauGK1aRrN6c1NKO0Ok5uNGEg_5b9gzenYCJ1gy7YLx18R8nJJW1yO7To4P8-XsHQUfrwFvoXACbdDc5TYk-doPu9bEb9LEbNGU6dwP_DUO7pVQ</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Liu, Xin</creator><creator>Beaty, Terri H</creator><creator>Deindl, Philipp</creator><creator>Huang, Shau-Ku</creator><creator>Lau, Susanne</creator><creator>Sommerfeld, Christine</creator><creator>Fallin, M.Daniele</creator><creator>Kao, W.H.Linda</creator><creator>Wahn, Ulrich</creator><creator>Nickel, Renate</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study</title><author>Liu, Xin ; Beaty, Terri H ; Deindl, Philipp ; Huang, Shau-Ku ; Lau, Susanne ; Sommerfeld, Christine ; Fallin, M.Daniele ; Kao, W.H.Linda ; Wahn, Ulrich ; Nickel, Renate</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e320t-a4b7a76e702b9b2558489e699d3bb7a015be5c0c7ed553de44cb8327a038b3a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age</topic><topic>Allergens</topic><topic>Allergies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cats</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Food</topic><topic>Food Hypersensitivity - genetics</topic><topic>Food Hypersensitivity - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes</topic><topic>Genetic Variation</topic><topic>Germany</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - genetics</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>IL13</topic><topic>IL4</topic><topic>IL4RA</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Interleukin-13 - genetics</topic><topic>Interleukin-4 - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mites - immunology</topic><topic>Receptors, Interleukin-4 - genetics</topic><topic>Sensitization</topic><topic>single nucleotide polymorphism</topic><topic>Smoking</topic><topic>Studies</topic><topic>Tobacco smoke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Beaty, Terri H</creatorcontrib><creatorcontrib>Deindl, Philipp</creatorcontrib><creatorcontrib>Huang, Shau-Ku</creatorcontrib><creatorcontrib>Lau, Susanne</creatorcontrib><creatorcontrib>Sommerfeld, Christine</creatorcontrib><creatorcontrib>Fallin, M.Daniele</creatorcontrib><creatorcontrib>Kao, W.H.Linda</creatorcontrib><creatorcontrib>Wahn, Ulrich</creatorcontrib><creatorcontrib>Nickel, Renate</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xin</au><au>Beaty, Terri H</au><au>Deindl, Philipp</au><au>Huang, Shau-Ku</au><au>Lau, Susanne</au><au>Sommerfeld, Christine</au><au>Fallin, M.Daniele</au><au>Kao, W.H.Linda</au><au>Wahn, Ulrich</au><au>Nickel, Renate</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>113</volume><issue>3</issue><spage>489</spage><epage>495</epage><pages>489-495</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the
IL4 gene, C-1055T and Arg130Gln in the
IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the
IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.
We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.
Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.
The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the
IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.
These findings not only suggested that variants in the
IL4,
IL13, and
IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15007352</pmid><doi>10.1016/j.jaci.2003.12.037</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | Age Allergens Allergies Animals Biological and medical sciences Case-Control Studies Cats Child Child, Preschool Female Food Food Hypersensitivity - genetics Food Hypersensitivity - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Genetic Variation Germany Haplotypes Humans Hypersensitivity, Immediate - genetics Hypersensitivity, Immediate - immunology IL13 IL4 IL4RA Immunoglobulin E - blood Immunopathology Infant Interleukin-13 - genetics Interleukin-4 - genetics Male Medical sciences Mites - immunology Receptors, Interleukin-4 - genetics Sensitization single nucleotide polymorphism Smoking Studies Tobacco smoke |
title | Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : The German Multicenter Atopy Study |
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