A silanediol inhibitor of the metalloprotease thermolysin: Synthesis and comparison with a phosphinic acid inhibitor

A silanediol inhibitor of the metalloprotease thermolysin was prepared for comparison to a known phosphinic acid inhibitor, providing the first comparison of these second-row element based transition-state analogues. Inhibition of thermolysin by the silanediol (K(i) = 41 nM) was comparable to that o...

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Veröffentlicht in:	Journal of organic chemistry 2004-04, Vol.69 (9), p.3008-3014
Hauptverfasser:	KIM, Jaeseung, SIEBURTH, Scott Mcn
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - chemistry Binding Sites Cations Chemistry Exact sciences and technology HIV Protease Inhibitors - chemistry Hydrolysis Hydrophobic and Hydrophilic Interactions Organic chemistry Organometalloidal and organometallic compounds Phosphinic Acids - chemistry Polymers - chemistry Preparations and properties Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Si derivatives Silanes - chemical synthesis Silanes - chemistry Structure-Activity Relationship Thermolysin - antagonists & inhibitors Zinc - chemistry
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