Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm
Studies were performed on humoral and cellular immune responses of patients from areas in Brazil endemic for hookworm and Ascaris lumbricoides, and either endemic or non-endemic for Schistosoma mansoni. Humoral and cellular responses were evaluated by enzyme-linked immunosorbant assay (ELISA) and pe...
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| Veröffentlicht in: | Acta tropica 2002-08, Vol.83 (2), p.123-132 |
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| creator | Corrêa-Oliveira, Rodrigo Golgher, Denise B Oliveira, Guilherme C Carvalho, Omar S Massara, Cristiano L Caldas, Iramaya R Colley, Daniel G Gazzinelli, Giovanni |
| description | Studies were performed on humoral and cellular immune responses of patients from areas in Brazil endemic for hookworm and
Ascaris lumbricoides, and either endemic or non-endemic for
Schistosoma mansoni. Humoral and cellular responses were evaluated by enzyme-linked immunosorbant assay (ELISA) and peripheral blood mononuclear cell (PBMC) proliferation assays against larval hookworm antigens,
A. lumbricoides egg antigens, and soluble egg antigens (SEA) or soluble whole adult antigenic preparation (SWAP) from
S. mansoni. Patients from
S. mansoni-endemic areas, who currently had only hookworm or Ascaris infections, expressed lower humoral and cellular responses to hookworm or Ascaris antigens, respectively, than did their counterparts from areas not endemic for
S. mansoni. Individuals from
S. mansoni endemic area, although without detectable
S. mansoni infection, do mount humoral and cellular responses to SEA and SWAP. This group of individuals has been probably in contact with
S. mansoni antigens, since the groups harboring
A. lumbricoides or hookworm infections from non-
S. mansoni endemic areas do not have detectable anti-
S. mansoni responses. PBMC proliferative responses discriminated well between patients with active hookworm infections versus ascariasis, if they were from areas not endemic for
S. mansoni. |
| doi_str_mv | 10.1016/S0001-706X(02)00108-0 |
| format | Article |
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Ascaris lumbricoides, and either endemic or non-endemic for
Schistosoma mansoni. Humoral and cellular responses were evaluated by enzyme-linked immunosorbant assay (ELISA) and peripheral blood mononuclear cell (PBMC) proliferation assays against larval hookworm antigens,
A. lumbricoides egg antigens, and soluble egg antigens (SEA) or soluble whole adult antigenic preparation (SWAP) from
S. mansoni. Patients from
S. mansoni-endemic areas, who currently had only hookworm or Ascaris infections, expressed lower humoral and cellular responses to hookworm or Ascaris antigens, respectively, than did their counterparts from areas not endemic for
S. mansoni. Individuals from
S. mansoni endemic area, although without detectable
S. mansoni infection, do mount humoral and cellular responses to SEA and SWAP. This group of individuals has been probably in contact with
S. mansoni antigens, since the groups harboring
A. lumbricoides or hookworm infections from non-
S. mansoni endemic areas do not have detectable anti-
S. mansoni responses. PBMC proliferative responses discriminated well between patients with active hookworm infections versus ascariasis, if they were from areas not endemic for
S. mansoni.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/S0001-706X(02)00108-0</identifier><identifier>PMID: 12088853</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Animals ; Antibodies ; Antibodies, Helminth - immunology ; Antibodies, Helminth - isolation & purification ; Ascariasis - epidemiology ; Ascariasis - immunology ; Ascaris lumbricoides ; Ascaris lumbricoides - immunology ; Biological and medical sciences ; Brazil - epidemiology ; Child ; Diseases caused by trematodes ; Distomatoses ; Enzyme-Linked Immunosorbent Assay ; Feces - parasitology ; Female ; Helminthic diseases ; Hookworm ; Hookworm Infections - epidemiology ; Hookworm Infections - immunology ; Humans ; Infectious diseases ; Male ; Medical sciences ; Parasitic diseases ; PBMC proliferation ; Prevalence ; Schistosoma mansoni ; Schistosoma mansoni - immunology ; Schistosomiasis - epidemiology ; Schistosomiasis - immunology ; Tropical medicine</subject><ispartof>Acta tropica, 2002-08, Vol.83 (2), p.123-132</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-54bb7ffe0e9889fb04976d35b57dd08a9fb41b20fec61cb608d4a1ca83b132a03</citedby><cites>FETCH-LOGICAL-c422t-54bb7ffe0e9889fb04976d35b57dd08a9fb41b20fec61cb608d4a1ca83b132a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0001-706X(02)00108-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13746806$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12088853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corrêa-Oliveira, Rodrigo</creatorcontrib><creatorcontrib>Golgher, Denise B</creatorcontrib><creatorcontrib>Oliveira, Guilherme C</creatorcontrib><creatorcontrib>Carvalho, Omar S</creatorcontrib><creatorcontrib>Massara, Cristiano L</creatorcontrib><creatorcontrib>Caldas, Iramaya R</creatorcontrib><creatorcontrib>Colley, Daniel G</creatorcontrib><creatorcontrib>Gazzinelli, Giovanni</creatorcontrib><title>Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Studies were performed on humoral and cellular immune responses of patients from areas in Brazil endemic for hookworm and
Ascaris lumbricoides, and either endemic or non-endemic for
Schistosoma mansoni. Humoral and cellular responses were evaluated by enzyme-linked immunosorbant assay (ELISA) and peripheral blood mononuclear cell (PBMC) proliferation assays against larval hookworm antigens,
A. lumbricoides egg antigens, and soluble egg antigens (SEA) or soluble whole adult antigenic preparation (SWAP) from
S. mansoni. Patients from
S. mansoni-endemic areas, who currently had only hookworm or Ascaris infections, expressed lower humoral and cellular responses to hookworm or Ascaris antigens, respectively, than did their counterparts from areas not endemic for
S. mansoni. Individuals from
S. mansoni endemic area, although without detectable
S. mansoni infection, do mount humoral and cellular responses to SEA and SWAP. This group of individuals has been probably in contact with
S. mansoni antigens, since the groups harboring
A. lumbricoides or hookworm infections from non-
S. mansoni endemic areas do not have detectable anti-
S. mansoni responses. PBMC proliferative responses discriminated well between patients with active hookworm infections versus ascariasis, if they were from areas not endemic for
S. mansoni.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Helminth - immunology</subject><subject>Antibodies, Helminth - isolation & purification</subject><subject>Ascariasis - epidemiology</subject><subject>Ascariasis - immunology</subject><subject>Ascaris lumbricoides</subject><subject>Ascaris lumbricoides - immunology</subject><subject>Biological and medical sciences</subject><subject>Brazil - epidemiology</subject><subject>Child</subject><subject>Diseases caused by trematodes</subject><subject>Distomatoses</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>Helminthic diseases</subject><subject>Hookworm</subject><subject>Hookworm Infections - epidemiology</subject><subject>Hookworm Infections - immunology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>PBMC proliferation</subject><subject>Prevalence</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis - epidemiology</subject><subject>Schistosomiasis - immunology</subject><subject>Tropical medicine</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotvCTwDlAiqHlLETO95TVVV8VKrUQ4vEzfLHRGuI7cVOqPj39XZX9NiTxzPPfOh9CXlH4YwCFZ9vAYC2A4ifp8A-1RhkCy_IisqhawXj_Uuy-o8ckeNSftUfGzh7TY4oAykl71ZkexVHtLNPsbn386a5tRtf5lRS0E3QsaToG5tyxknPWPaMnmbM6BofwhKxyVi2KZZanVNzUazOvjTTEkz2NnlX8zq6ZpPS7_uUwxvyatRTwbeH94T8-Prl7vJ7e33z7ery4rq1PWNzy3tjhnFEwLWU69FAvx6E67jhg3MgdU311DCoxwtqjQDpek2tlp2hHdPQnZCP-7nbnP4sWGYVfLE4TTpiWooaqBTAevks2DFOKWe7iXwP2pxKyTiqbfZB53-Kgtp5oh49UTvBFTD16Ina9b0_LFhMQPfUdTChAh8OgK7qTWPW0fryxHVDLySIyp3vOay6_fWYVbEeo0Xnc_VQueSfOeUBU0arRw</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Corrêa-Oliveira, Rodrigo</creator><creator>Golgher, Denise B</creator><creator>Oliveira, Guilherme C</creator><creator>Carvalho, Omar S</creator><creator>Massara, Cristiano L</creator><creator>Caldas, Iramaya R</creator><creator>Colley, Daniel G</creator><creator>Gazzinelli, Giovanni</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm</title><author>Corrêa-Oliveira, Rodrigo ; Golgher, Denise B ; Oliveira, Guilherme C ; Carvalho, Omar S ; Massara, Cristiano L ; Caldas, Iramaya R ; Colley, Daniel G ; Gazzinelli, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-54bb7ffe0e9889fb04976d35b57dd08a9fb41b20fec61cb608d4a1ca83b132a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Helminth - immunology</topic><topic>Antibodies, Helminth - isolation & purification</topic><topic>Ascariasis - epidemiology</topic><topic>Ascariasis - immunology</topic><topic>Ascaris lumbricoides</topic><topic>Ascaris lumbricoides - immunology</topic><topic>Biological and medical sciences</topic><topic>Brazil - epidemiology</topic><topic>Child</topic><topic>Diseases caused by trematodes</topic><topic>Distomatoses</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Feces - parasitology</topic><topic>Female</topic><topic>Helminthic diseases</topic><topic>Hookworm</topic><topic>Hookworm Infections - epidemiology</topic><topic>Hookworm Infections - immunology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>PBMC proliferation</topic><topic>Prevalence</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - immunology</topic><topic>Schistosomiasis - epidemiology</topic><topic>Schistosomiasis - immunology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corrêa-Oliveira, Rodrigo</creatorcontrib><creatorcontrib>Golgher, Denise B</creatorcontrib><creatorcontrib>Oliveira, Guilherme C</creatorcontrib><creatorcontrib>Carvalho, Omar S</creatorcontrib><creatorcontrib>Massara, Cristiano L</creatorcontrib><creatorcontrib>Caldas, Iramaya R</creatorcontrib><creatorcontrib>Colley, Daniel G</creatorcontrib><creatorcontrib>Gazzinelli, Giovanni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corrêa-Oliveira, Rodrigo</au><au>Golgher, Denise B</au><au>Oliveira, Guilherme C</au><au>Carvalho, Omar S</au><au>Massara, Cristiano L</au><au>Caldas, Iramaya R</au><au>Colley, Daniel G</au><au>Gazzinelli, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>83</volume><issue>2</issue><spage>123</spage><epage>132</epage><pages>123-132</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><coden>ACTRAQ</coden><abstract>Studies were performed on humoral and cellular immune responses of patients from areas in Brazil endemic for hookworm and
Ascaris lumbricoides, and either endemic or non-endemic for
Schistosoma mansoni. Humoral and cellular responses were evaluated by enzyme-linked immunosorbant assay (ELISA) and peripheral blood mononuclear cell (PBMC) proliferation assays against larval hookworm antigens,
A. lumbricoides egg antigens, and soluble egg antigens (SEA) or soluble whole adult antigenic preparation (SWAP) from
S. mansoni. Patients from
S. mansoni-endemic areas, who currently had only hookworm or Ascaris infections, expressed lower humoral and cellular responses to hookworm or Ascaris antigens, respectively, than did their counterparts from areas not endemic for
S. mansoni. Individuals from
S. mansoni endemic area, although without detectable
S. mansoni infection, do mount humoral and cellular responses to SEA and SWAP. This group of individuals has been probably in contact with
S. mansoni antigens, since the groups harboring
A. lumbricoides or hookworm infections from non-
S. mansoni endemic areas do not have detectable anti-
S. mansoni responses. PBMC proliferative responses discriminated well between patients with active hookworm infections versus ascariasis, if they were from areas not endemic for
S. mansoni.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12088853</pmid><doi>10.1016/S0001-706X(02)00108-0</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-706X |
| ispartof | Acta tropica, 2002-08, Vol.83 (2), p.123-132 |
| issn | 0001-706X 1873-6254 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Animals Antibodies Antibodies, Helminth - immunology Antibodies, Helminth - isolation & purification Ascariasis - epidemiology Ascariasis - immunology Ascaris lumbricoides Ascaris lumbricoides - immunology Biological and medical sciences Brazil - epidemiology Child Diseases caused by trematodes Distomatoses Enzyme-Linked Immunosorbent Assay Feces - parasitology Female Helminthic diseases Hookworm Hookworm Infections - epidemiology Hookworm Infections - immunology Humans Infectious diseases Male Medical sciences Parasitic diseases PBMC proliferation Prevalence Schistosoma mansoni Schistosoma mansoni - immunology Schistosomiasis - epidemiology Schistosomiasis - immunology Tropical medicine |
| title | Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm |
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